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M. Asunción Mejías, MD, PhD, MsCS
M. Asunción Mejías, MD, PhD, MsCS

M. Asunción Mejías, MD, PhD, MsCS

Member, St. Jude Faculty

Departments

Education

MD - Facultad de Medicina, University of Málaga, Spain
PhD - Universidad Autonoma de Madrid & Facultad de Medicina and University of Málaga, Spain
MsCS (Master’s in Clinical Sciences) - University of Texas Southwestern Medical School, Dallas, TX

Honors and Awards

  • 2006 ICAAC Program Committee Award
  • 2010 Summa Cum Laude Thesis Award
  • 2014 Caroline B. Hall Clinically Innovative Research Award, sponsored by the Pediatric Infectious Diseases Society

Research Interests

  • Viral respiratory infections
  • Perinatal infections including CMV and HSV
  • Data science
  • Integration of immune parameters with patient’s clinical phenotype

Selected Publications

Full list of publications

Mejias A, Schuchard J, Rao S, Bennett T.D, Jhaveri R, Thacker D, Bailey CB, Christakis DA, Pajor NM, Razzaghi H, Forrest CB, Lee GM. Leveraging serology testing to identify children at risk for post-acute sequelae of SARS-CoV-2 infection: An EHR-based cohort study from the RECOVER program. J Pediatr 2023 (in press). PMID: 36822507

Wang H, Wright T, Oyeniran SJ, Mejias A, Leber A. SARS-CoV-2 reinfection with different SARS-CoV-2 variants in children, Ohio, US. J Pediatric Infect Dis Soc 12(4):198-204, 2023. PMID: 37004190

Ben-Shimol S, Ramilo O, Leber A.L, Van der Beek BA, Everhart K, Mertz S, Mejias A, Dagan R. A Hypothesis Generating Prospective Longitudinal Study to Assess the Relative Contribution of Common Respiratory Viruses to Severe Lower Respiratory Infections in Young Children. Ped Infect Dis J 42(5):396-404, 2023. PMID: 36917029

Lorman V, Rao S, Jhaveri R, Case A, Mejias A, Pajor N.M, Patel P, Thacker D, Bose-Brill S, Block J, Hanley P.C, Prahalad P, Chen Y, Forrest C.B, Bailey C, Lee G.M, Razzaghi H. Understanding Pediatric Long-COVID Using a Tree-Scan Statistics Approach: An EHR-Based Cohort Study from the RECOVER Program. J Am Med Inform Assoc (JAMIA) Open 16(1):ooad016, 2023. PMID: 36926600

Mazur, NI, Terstappen J, Baral R, Bardají A, Beutels P, Buchholz UJ,  Cohen S, Crowe JE Jr,   Cutland CL, Eckert L, Feikin D,  Fitzpatrick T, Fong Y, Graham B, Heikkinen T, Higgins D, Hirve S, Klugman K,  Kragten-Tabatabaie L,  Lemey P,  Libster R, Löwensteyn Y,  Mejias A, Munoz FM,  Munywoki PK, Mwananyanda L,  Nair H,  Nunes MC,  Ramilo O,  Richmond P, Ruckwardt TJ, Sande C, Srikantiah P,  Thacker N, Waldstein KA, Weinberger D, Wildenbeest J, Wiseman D, Zar HJ, Zambon M, Bont L. Respiratory Syncytial Virus Prevention within Reach: The Vaccine and Monoclonal Antibody Landscape. Lancet Infect Dis 23(1):e2-e21, 2023. PMID: 35952703

Taveras J, Garcia-Maurino C, Moore-Clingenpeel M, Xu Z, Mertz S, Ye F, Chen P, Cohen SH, Cohen D, Peeples ME, Ramilo O, Mejias A. Type-III Interferons, Viral Loads, Age, and Disease Severity in Young Children with Respiratory Syncytial Virus Infection. J infect Dis  227(1):61-70, 2022. PMID: 36200173

Halabi K, Wang H, Leber A.L, Sanchez P.J, Ramilo O, Mejias A. Respiratory Syncytial Virus and SARS-CoV-2 Coinfections in Children. Pediatr Pulmonol 57(12):3158-60, 2022. PMID: 35997032

Quintero AM, Eisner M, Sayegh R, Wright T, Ramilo O, Leber A.L, Wang H, Mejias A. Differences in clinical presentations and disease severity in children and adolescents according to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variant. Emerg Infect Dis 28(11):2270-80, 2022. PMID: 36285986

Rao S, Lee GM, Razzaghi H, Lorman V, Mejias A, Pajor NM, Thacker D, Webb R, Dickinson K, Bailey CL, Jhaveri R, Christakis DA, Bennett TD, Chen Y, Forrest CB. Clinical features and burden of post-acute sequelae of SARS-CoV-2 infection in children and adolescents: an exploratory EHR-based cohort study from the RECOVER program. JAMA Pediatr 176(10):1000-09, 2022. PMID: 3599428

Bline K, Andrews A, Mertz S, Ye F, Best V, Sayegh R, Tomatis-Souverbielle C, Quintero AM, Maynard Z, Mejias A, Ramilo O.  Myeloid-derived suppressor cells and clinical outcomes in children with COVID-19. Front Pediatr 10:893045, 2022. PMID: 35733812

Forest CB, Burrows E, Mejias A, Razzaghi H, Chistakis D, Jhaveri R, Lee GM, Pajor NM, Rao S, Thacker D, L. Bayley C. Severity of Acute COVID-19 in Children and Adolescents < 18 years old March to September 2021. Pediatrics 149 (2):e2021055765, 2022. PMID: 35322270

Koivisto K, Nieminen T, Mejias A, Capella C, Ye F, Mertz S, Peeples ME, Ramilo O, Saxén H. RSV Specific Antibodies in Pregnant Women and Subsequent Risk of RSV Hospitalization in Young Infants. J Infect Dis 225(7):1189-96, 2022. PMID: 34129040

Diaz-Diaz A, Bunsow E, Garcia-Maurino C, Moore-Clingenpeel M, Naples J, Juergensen A, Mertz S, Wang H, Leber AL, Gern J, Hall MW, Cohen D, Ramilo O, Mejias A. Nasopharyngeal Codetection of H. influenzae and S. pneumoniae Shapes Respiratory Syncytial Virus Disease Outcomes in Children. J Infect Dis 225(5):912-923, 2022. PMID: 34543409

Mertz C, Glowinski R, Cohen S.H, Mertz S, Ye F, Hall M.W, Peeples M.E, King T, Wang H, Leber A.L, Sanchez P.J, Ramilo O, Mejias A. SARS-CoV-2 RNAemia and clinical outcomes in children with COVID-19. J Infect Dis 225(2):208-13, 2022. PMID: 34618885

Shutes BL, Patel AB, Moore-Clingenpeel M, Mejias A, Karsies TJ. Relationship of viral detection with duration of ventilation in critically ill infants with lower respiratory tract infection. Ann Am Thorac Soc 18(10):1667-84, 2021. PMID: 33662231

Mejias A, Brenes-Chacon H, Garcia-Mauriño C, Moore-Clingenpeel M, Ramilo O. Clinical Disease Severity Scores and Viral Loads in Children with RSV Infection. Clin Infect Dis 72(12):e1160-62, 2021. PMID: 33215632

Lu M, Dravid P, Zhang Y, Trivedi S, Li A, Harder O, KC M, Chaiwatpongsakorn S, Zani A, Kenney A, Zeng C, Cai C, Ye C, Liang X, Shimamura M, Liu SL, Mejias A, Ramilo O, Boyaka PN, Qiu J, Martinez-Sobrido L, Yount J, Peeples M, Kapoor A, Niewiesk S, Li J. A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike. Proc Natl Acad Sci US (PNAS) 118(12):e2026153118, 2021. PMID: 33688034

King T, Mejias A, Ramilo O, Peeples ME. The larger attachment glycoprotein of respiratory syncytial virus produced in primary human bronchial epithelial cultures reduces infectivity for cell lines. PLoS Pathogens 17(4):e1009469, 2021. PMID: 33831114

Brenes-Chacon H, Garcia-Maurino C, Moore-Clingenpeel M, Mertz S, Ye F, Cohen D, Ramilo O, Mejias A. Age-Dependent Interactions Among Clinical Characteristics, Viral Loads, and Disease Severity in Young Children with Respiratory Syncytial Virus Infection. Ped Infect Dis J 40(2):116-22, 2021. PMID: 33433159

Ouellette CP, Sánchez PJ, Xu Z, Blankenship D, Zeray F, Ronchi A, Shimamura M, Chaussabel D, Lee L, Owen KE, Shoup AG, Ramilo O, Mejias A. Blood Genome Expression Profiles in Infants with Congenital Cytomegalovirus Infection. Nat Commun 11(1):3548, 2020. PMID: 32669541

Heinonen S, Velazquez VM, Ye F, Mertz S, Acero-Bedoya S, Smith B, Bunsow E, Garcia-Mauriño C, Oliva S, Cohen DM, Moore-Clingenpeel M, Peeples ME, Ramilo O, Mejias A. Immune Profiles Provide Insights into Respiratory Syncytial Virus Disease Severity in Young Children. Science Translational Medicine Apr 22;12(540):eaaw0268, 2020. PMID:3232186

Moreno-Galdó A, Pérez-Yarza E, Ramilo O, Rubí T, Escribano A, Torres A, Sardón O, Oliva C, Pérez G, Cortell I, Rovira-Amigo S, Pastor-Vivero D, Pérez-Frías J, Velasco V, MD, Torres-Borrego J, Figuerola J, Barrio I, García-Hernández G, Mejias A. Recurrent Wheezing During the First 3 Years of Life in a Birth Cohort of Moderate-to-Late Preterm Infants. Ped Allergy and Immunol 31(2):124-132, 2020. PMID:31597224.

Mejias A, Wu B, Tandon N, Chow W, Varma R, Franco E, Ramilo O. Risk of Childhood Wheeze and Asthma after Respiratory Syncytial Virus Infection in Full-Term Infants. Ped Allergy and Immunol 31(1):47-56, 2020. PMID:31566811

Garcia-Mauriño C, Moore-Clingenpeel M, Thomas J, Mertz S, Cohen D.M, Ramilo O, Mejias A. Viral Load Dynamics and Clinical Disease Severity in Infants with Respiratory Syncytial Virus Infection. J Infect Dis 219(8):1207-1215, 2019. PMID:30418604

Garcia-Maurino C, Moore-Clingenpeel M, Wallihan R, Koranyi K, Rajah B, Shirk T, Vegh M, Ramilo O, Mejias A. Discharge Criteria for Bronchiolitis: An Unmet Need. Pediatr Infect Dis J 37(6):514-19, 2018. PMID:29189658

Capella C, Chaiwatpongsakorn S, Gorrell E, Risch ZA, Ye F, Mertz S, Johnson SM, Moore-Clingenpeel M, Ramilo O, Mejias A*, Peeples ME. Prefusion F, postfusion F, G antibodies and disease severity in infants and young children with acute respiratory syncytial virus infection.  J Infect Dis 216(11):1398-1406, 2017. PMID:29029312 *Corresponding author

Moyer K, Wang H, Salamon D, Leber A, Mejias A. Enterovirus D68 in Hospitalized Children: Sequence Variation, Viral Loads and Clinical Outcomes. PLoS One  11(11):e0167111, 2016. PMID: 27875593

Steenhuijsen Piters W, Heinonen S, Hasrat R, Bunsow E, Smith B, Suarez-Arrabal MC, Chaussabel D, Cohen DM, Sanders E, Ramilo O, Bogaert D, Mejias A. Nasopharyngeal microbiota, host transcriptome and disease severity in children with respiratory syncytial virus infection. Am J Respir Crit Care Med 194(9):1104-15, 2016. PMID: 27135599

Heinonen S, Jartti T, Garcia C, Oliva S, Smitherman C, Anguiano E, de Steenhuijsen Piters WA, Vuironen T, Ruuskanen O, Dimo B, Suarez NM, Pascual V, Ramilo O, Mejias A. Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis. Am J Respir Crit Care Med 193(7):772-82, 2016. PMID: 26571305

Suárez-Arrabal MC, Mella C, Lopez S, Brown NV, Hall W. M, Hammond S, Shiels W, Groner J, Marcon M, Ramilo O, Mejias A. Nasopharyngeal Bacterial Burden and Antibiotics: Influence on Inflammatory Markers and Disease Severity in Infants with Respiratory Syncytial Virus Bronchiolitis. J Infect 71(4):458-69, 2015. PMID: 26149186

Mejias, A., Dimo, B., Suarez, N, Garcia, C., Suarez-Arrabal, M. C, Jartti, T, Blankenship, D, Jordan-Villegas, A, Ardura, M.I, Zhaohui, X, Banchereau, J, Chaussabel, D, Ramilo, O. Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection. PLoS Med 10(11):e1001549, 2013. PMID: 24265599

Last update: June 2023

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