General registration for the 2025 St. Jude Memphis Marathon Weekend presented by Juice Plus+ is now open! Registration fees help us put on a great race, but fundraising is the best way to help the kids of St. Jude. Fundraising is not required for general participants but your efforts will help us reach our goal of more than $16M for the St. Jude mission: Finding cures. Saving children.

Every child deserves a chance to live their best life and celebrate every moment. Join us Saturday, Dec. 6 for St. Jude Memphis Marathon Weekend presented by Juice Plus+, the largest single-day fundraising event for St. Jude Children’s Research Hospital and help make cures possible for kids with cancer.

Beale Street district. The Mississippi Riverfront. Historic neighborhoods. Outstanding spectator support. Plus, each course runs through the heart of the St. Jude campus. Whether you register for the marathon, half marathon, 10K, 5K or 2-Race Challenge, or want to volunteer or cheer instead, know it’s all in support of the kids of St. Jude.

Thank you and welcome to our team!

Questions? Contact us at marathon@alsac.stjude.org or 800-565-5112.

Make a donation to support an individual Get Fundraising Resources

Your support means so much to the kids of St.Jude.

St. Jude patient Katherin capped off a big year with a first-time run in the St. Jude Memphis Marathon® Weekend. As the half-marathon route took her through the St. Jude campus, the cancer survivor was flooded with memories of her treatment there.

St. Jude patient Katherin

I kind of like teared up a little bit, just because I saw the great emotion from families that were standing there and just saw the support. I don't know them, but you could feel the love and encouragement from each one of them, Katherin said.

Read about St. Jude patient Katherin's marathon journey.