What is tobramycin?

Tobramycin (also called Nebcin®) is a medicine used to treat infections. Tobramycin is available as a clear liquid given by a vein (IV), as eye drops, and as an eye ointment.

Possible side effects of tobramycin (IV form)

  • Decreased kidney function
  • Feeling dizzy
  • Trouble standing
  • Hearing a roaring noise
  • Loss of hearing
  • Muscle twitching or feeling weak
  • Need to urinate less
  • Diarrhea
  • Nausea
  • Vomiting
  • Upset stomach
  • Allergic reaction with these symptoms: rash, hives, itching, chills, fever, short of breath, muscle aches, swelling of the face or neck, headache, tight feeling in throat, or coughing

Possible side effects of tobramycin (eye drops and eye ointment)

  • Irritated eye that was not present before using this medicine
  • Burning or stinging of the eye
  • Tearing
  • Blurred vision for the first few minutes after using this medicine. If the blurred vision continues, tell your doctor.

These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse. In case of a severe side effect or reaction, call the doctor, nurse, or pharmacist at 595-3300. If you are outside the Memphis area, dial toll-free 1-866-2STJUDE (1-866-278-5833), and press 0 once the call is connected.

Special instructions for tobramycin

  • If you are not urinating as often as usual (decreased kidney function), tell your doctor before you receive the IV form of tobramycin.
  • The staff will measure the amount of tobramycin in your blood shortly after you receive IV tobramycin. These blood tests make sure you are receiving an effective dose of tobramycin and decrease the chance for side effects.
  • Tell your doctor right away if you are not urinating as often as usual while you are receiving IV tobramycin.
  • If you are an outpatient receiving IV tobramycin through a portable pump (such as a Sidekick) follow these guidelines:
    • Finish all doses of tobramycin as your doctor instructed, even if you think your condition has improved.
    • Store tobramycin in the refrigerator or on ice.
    • Place one (1) dose of tobramycin at room temperature about one (1) hour before the dose is given.
  • Tell your doctor right away if you have any changes in hearing while you are receiving the IV form of tobramycin.
  • While you are receiving IV tobramycin, it is important to stay well-hydrated. If you are not receiving IV fluids, drink plenty of fluids. Ask your doctor, nurse, or pharmacist how much fluid you should have each day.
  • Some medicines may make the side effects of IV tobramycin worse. These medicines include furosemide, cyclosporine, amphotericin B or Ambisome®, tacrolimus, cephalosporin antibiotics (such as Cefepime® and Ceftazidime®), cisplatin, and carboplatin.
  • Tell your doctor if you are taking any of these medicines, or if you start taking any new medicines while you are receiving IV tobramycin.
  • If you are using tobramycin for an eye infection, follow these guidelines:
    • Do not let the tip of the ointment tube or eye drop bottle touch your eye or anything else while the cap is off.
    • Tilt your head back to place the medicine in your eye.
    • Use your finger to pull down the lower lid of your eye to form a pocket.
    • Squeeze the prescribed amount of ointment or number of drops into the pocket between the lower lid of the eye and the eyeball.
    • Gently close your eye, and keep it closed for about one (1) minute.
    • Store the tobramycin eye ointment or eye drops at room temperature in a dry place.


This document is not intended to take the place of the care and attention of your personal physician or other professional medical services. Our aim is to promote active participation in your care and treatment by providing information and education. Questions about individual health concerns or specific treatment options should be discussed with your physician.

St. Jude complies with health care-related federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex.

ATTENTION: If you speak another language, assistance services, free of charge, are available to you. Call 1-866-278-5833 (TTY: 1-901-595-1040).

ATENCIÓN: si habla español, tiene a su disposición servicios gratuitos de asistencia lingüística. Llame al 1-866-278-5833 (TTY: 1-901-595-1040).

تنبيه: إذا كنت تتحدث باللغة العربية فيمكنك الاستعانة بخدمات المساعدة اللغوية المتوفرة لك مجانا. .يرجى الاتصال بالرقم. 5833-278-866-1  (الهاتف النصي: 1040-595-901-1).