Paula Arnold, PhD, D(ABHI)
Paula Arnold, PhD, D(ABHI)

Paula Arnold, PhD, D(ABHI)

Assistant Member, St. Jude Faculty

Departments

Education

BA (Biology) - University of Virginia, Charlottesville, VA
PhD - East Carolina University, Greenville, NC
Postdoctoral Fellowship - St. Jude Children’s Research Hospital, Memphis, TN
HLA Director Training - St. Jude Children’s Research Hospital, Memphis, TN

Research Interests

  • HLA and KIR testing and donor selection for hematopoietic cell transplantation
  • HLA haplotype loss in leukemia relapse after HLA-mismatched hematopoietic cell transplantation
  • Donor-specific HLA antibodies and desensitization in HLA-mismatched hematopoietic cell transplantation

Selected Publications

Chang T-C, Carter R, Li Y, Li Y, Wang H, Edmonson MN, Chen X, Arnold P, Geiger TL, Wu G, Peng J, Dyer M, Downing JR, Green DR, Thomas PG, Zhang J. The neoepitope landscape in pediatric cancers. Genome Medicine Aug 31;9(1):78, 2017.

Turner EV, Dilioglou S, Arnold PY, Palma J, Rivera G. The HLA-A*68:23 allele in the Chilean population. Tissue Antigens December;84(6):565-567, 2014.

Lennon GP, Bettini M, Burton AR, Vincent E, Arnold PY, Santamaria P, Vignali DAA. T cell islet accumulation in type 1 diabetes is a tightly regulated, cell autonomous event. Immunity Oct 16;31(4):643-53, 2009.

Burton AR, Vincent E, Arnold PY, Lennon, G, Smeltzer M, Li C-S, Haskins K, Hutton J, Tisch RM, Sercarz EE, Santamaria P, Workman CJ, Vignali DAA. On the pathogenicity of autoantigen-specific T cell receptors. Diabetes 57: 1321-1330, 2008.

Arnold PY, Burton AR, Vignali DAA. Diabetes incidence is unaltered in glutamate decarboxylase-65- specific TCR retrogenic non-obese diabetic mice: Generation by retroviral-mediated stem cell gene transfer. J Immunol Sep 1; 173 (5):3103-11, 2004.

Arnold PY, Vignali KM, Miller TB, La Gruta NL, Cauley LS, Haynes L, Adams PS, Swain SL, Woodland DL, Vignali DAA. Reliable generation and use of MHC class II-gamma2aFc multimers for the identification of antigen-specific CD4+ T cells. J Immunol Methods 271:137-151, 2002.

Arnold PY, La Gruta NL, Miller TB, Vignali KM, Adams PS, Woodland DL, Vignali DAA. The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide flanking residues. J Immunol 169:739-749, 2002.

Patel DM, Arnold PY, White GA, Nardella JN, Mannie MD. Class II MHC/peptide complexes are released from APC and are acquired by T cell responders during specific antigen recognition. J Immunol 163:5201- 5210, 1999.

Arnold PY, Nardella JN, White GW, Mannie MD. Vesicles bearing MHC class II molecules mediate transfer of antigen from antigen-presenting cells to CD4+ T cells. Eur J Immunol 29:1363- 1373, 1999.

Arnold PY, Kearse KP, Marinakis CA, Mannie MD. A novel monoclonal antibody against rat LFA-1: blockade of LFA-1 and CD4 augments class II MHC expression on T cells. Hybridoma 17:331-338, 1998.

Mannie MD, Nardella JP, White GA, Arnold PY (corresponding). Class II MHC/ peptide complexes on T cell antigen presenting cells: agonistic antigen recognition inhibits subsequent antigen presentation. Cell Immunol 186: 111-120, 1998.

Mannie MD, White GA, Nardella JP, Davidian DK, Arnold PY (corresponding). Partial agonism elicits an enduring phase of T cell-mediated antigen presentation. Cell Immunol 186:83-93, 1998.

Arnold PY, Davidian DK, Mannie MD. Antigen presentation by T cells: T cell receptor ligation promotes antigen acquisition from professional antigen presenting cells. Eur J Immunol 27:3198-3205, 1997.

Mannie MD, Rendall SK, Arnold PY, Nardella JP, White GA. Anergy-associated T cell antigen presentation: a mechanism of infectious tolerance in experimental autoimmune encephalomyelitis. J Immunol 157:1062- 1070, 1996.

Last update: October 2020

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