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Senthil Bhoopalan, MBBS, PhD, FAA
Senthil Bhoopalan, MBBS, PhD, FAAP

Senthil Bhoopalan, MBBS, PhD, FAAP

Instructor, St. Jude Faculty



MBBS - Kilpauk Medical College, Chennai, TN, India
PhD - University of Maryland, College Park, MD
Residency (Pediatrics) - University of Nevada, Las Vegas, NV
Clinical Fellowship (Pediatric Hematology-Oncology) – St. Jude Children’s Research Hospital, Memphis, TN

Honors & Awards

  • 2023 Diamond-Blackfan Anemia Foundation Research Grant
  • 2023 ASH Scholar Award
  • 2022 ASH Research Training Award for Fellows
  • 2021  Basic Research Award (Society for Pediatric Research)
  • 2021  ASTCT Clinical Research Training Course (CRTC) Scholar
  • 2021  ASH Research Training Award for Fellows

Research Interests

  • Gene therapy and genome editing
  • Inherited bone marrow failure syndromes, with particular focus on Diamond-Blackfan anemia
  • Role of ribosomes in hematopoiesis
  • Bone marrow transplantation for bone marrow failure syndromes

Selected Publications

Sharma A, Galimard JE, Pryce A, Bhoopalan SV, Dalissier A, Dalle JH, Locatelli F, Jubert C, Mirci-Danicar O, Kitra-Roussou V, Bertrand Y, Fagioli F, Rialland F, Biffi A, Wynn RF, Michel G, Tambaro FP, Al-Ahmari A, Tbakhi A, Furness CL, Diaz MA, Sedlacek P, Bodova I, Faraci M, Rao K, Kleinschmidt K, Petit A, Gibson B, Bhatt NS, Kalwak K, Corbacioglu S. Cytogenetic abnormalities predict survival after allogeneic hematopoietic stem cell transplantation for pediatric acute myeloid leukemia: A PDWP/EBMT study. Bone Marrow Transplant Jan 15, 2024.

Bhoopalan SV, Suryaprakash S, Sharma A, Wlodarski MW, Hematopoietic cell transplantation and gene therapy for Diamond-Blackfan anemia: State of the art and science. Front Oncol 13:1236038, 2023.

Mayuranathan T, Newby GA, Feng R, Yao Y, Mayberry KD, Lazzarotto CR, Li Y, Levine RM, Nimmagadda N, Dempsey E, Kang G, Porter SN, Doerfler PA, Zhang J, Jang Y, Chen J, Bell HW, Crossley M, Bhoopalan SV, Sharma A, Tisdale JF, Pruett-Miller SM, Cheng Y, Tsai SQ, Liu DR, Weiss MJ, Yen JS. Potent and uniform fetal hemoglobin induction via base editing. Nat Genet 55(7):2320-2330, 2023.

Troullioud Lucas AG, Lindemans CA, Bhoopalan SV, Dandis R, Prockop SE, Naik S, Keerthi D, de Koning C, Sharma A, Nierkens S, Boelens JJ. Early immune reconstitution as predictor for outcomes after allogeneic hematopoietic cell transplant; a tri-institutional analysis. Cytotherapy Jun 16, 2023.

Natarajan RK, Bhoopalan SV, Cross C, Shah R, Rothman A. Novel score to predict immunoglobulin resistance in Kawasaki disease. Pediatr Cardiol May 12, 2023.

Everette KA, Newby GA, Levine RM, Mayberry K, Jang Y, Mayuranathan T, Nimmagadda N, Dempsey E, Li Y, Bhoopalan SV, Liu X, Davis JR, Nelson AT, Chen PJ, Sousa AA, Cheng Y, Tisdale JF, Weiss MJ, Yen JS, Liu DR. Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice. Nat Biomed Eng Apr 17, 2023.

Bhoopalan SV, Yen JS, Mayuranathan T, Mayberry KD, Yao Y, Lillo Osuna MA, Jang Y, Liyange JS, Blanc L, Ellis SR, Wlodarski MW, Weiss MJ. An RPS19-edited model for Diamond-Blackfan anemia reveals TP53-dependent impairment of hematopoietic stem cell activity. JCI Insight Nov 22, 2022.

Aurora T, Joseph N, Bhoopalan SV, Caniza MA, Flerlage T, Ghafoor S, Hankins J, Hijano DR, Jesudas R, Kirkham J, Martinez H, Alfaro GM, Sharma A, Hines M. The successful use of eculizumab for treatment of thrombotic microangiopathy in pediatric acute SARS-CoV2 infection and multisystem inflammatory syndrome in children. Haematologica May 26, 2022.

Bhoopalan SV, Wlodarski M, Reiss U, Triplett B, Sharma A. Reduced-intensity conditioning-based hematopoietic cell transplantation for dyskeratosis congenita: Single-center experience and literature review. Pediatr Blood Cancer Jun 4:e29177, 2021. doi: 10.1002/pbc.29177. Epub ahead of print. PMID: 34086408

Bhoopalan SV, Huang LJ, Weiss MJ. Erythropoietin regulation of red blood cell production: from bench to bedside and back. F1000Res 9, 2020. PubMed PMID: 32983414

Bhoopalan SV, Cross SJ, Panetta JC, Triplett BM. Pharmacokinetics of alemtuzumab in pediatric patients undergoing ex vivo T-cell-depleted haploidentical hematopoietic cell transplantation. Cancer Chemother Pharmacol Dec;86(6):711-717, 2020. PubMed PMID: 33037919

Karayel Ö, Xu P, Bludau I, Bhoopalan SV, Yao Y, Ana Rita FC, Santos A, Schulman BA, Alpi AF, Weiss MJ, Mann M. Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis. Mol Syst Biol Dec;16(12):e9813, 2020. PubMed PMID: 33259127

Bhoopalan SV, Piekarowicz A, Lenz JD, Dillard JP, Stein DC. NagZ triggers gonococcal biofilm disassembly. Scientific Reports Mar 1;6:22372, 2016.

Stein DC, Miller CJ, Bhoopalan SV, Sommer DD. Sequence-based predictions of lipooligosaccharide diversity in the Neisseriaceae and their implication in pathogenicity. PLoS One Apr 18;6(4):e18923, 2011.

Bagyalakshmi R, Bhoopalan SV, Therese KL, Murugusundram S, Madhavan HN. Application of polymerase chain reaction (PCR) and PCR-based restriction fragment length polymorphism for detection and identification of dermatophytes from dermatological specimens. Indian Journal of Dermatology Jan;53(1):15, 2008.

Last update: February 2024