Xinwei Cao, PhD
Xinwei Cao, PhD

Xinwei Cao, PhD

Assistant Member, St. Jude Faculty

Departments

Education

PhD – University of Texas Southwestern Medical Center at Dallas, Texas
BS – Beijing (Peking) University, Beijing, China

Research Interests

  • To define mechanisms that regulate the growth of the vertebrate nervous system
  • To understand how growth-control mechanisms are coupled with patterning mechanisms to achieve the proper size, shape, and cytoarchitecture of the nervous system
  • To determine the connection between growth-control mechanisms and human neurological tumors and malformations
  • To identify the genetic basis of brain size evolution

Selected Publications

Serinagaoglu Y, Paré J, Giovannini M, Cao X. Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol 398:97-109, 2015.

Lavado A, Ware M, Paré J, Cao X. The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap. Development 141: 4182-93, 2014. Featured in Editor’s Choice, Sci Signal (7) ec305 http://stke.sciencemag.org/content/7/349/ec305.abstract

Lavado A, He Y, Paré J, Neale G, Olson EN, Giovannini M, Cao X. Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development 140: 3323-34, 2013.

Denli AM, Cao X, Gage FH. miR-9 and TLX: chasing tails in neural stem cells. Nat Struct Mol Biol 16:346-347, 2009.

Cao X, Pfaff SL, Gage FH. YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes & Dev 22:3320-3334, 2008.

Cao X, Pfaff SL, Gage FH. A functional study of miR-124 in the developing neural tube. Genes & Dev 21:531-536, 2007.

Cao X, Yeo G, Muotri AR, Kuwabara T, Gage FH. Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci 29:77-103, 2006.

Cao X, Südhof TC. Dissection of amyloid-β precursor protein-dependent transcriptional transactivation. J Biol Chem 279:24601-11, 2004.

Biederer T, Cao X, Südhof TC, Liu X. Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms. J Neurosci 22:7340-51, 2002.

Cao X, Südhof TC. A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293:115-20, 2001.

Last update: January 2015