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Xinwei Cao, PhD
Xinwei Cao, PhD


PhD – University of Texas Southwestern Medical Center at Dallas, Texas
BS – Beijing (Peking) University, Beijing, China

Research Interests

  • To define mechanisms that regulate the growth of the vertebrate nervous system
  • To understand how growth-control mechanisms are coupled with patterning mechanisms to achieve the proper size, shape, and cytoarchitecture of the nervous system
  • To determine the connection between growth-control mechanisms and human neurological tumors and malformations
  • To identify the genetic basis of brain size evolution

Selected Publications

Lavado A, Park JY, Paré J, Finkelstein D, Pan H, Xu B, Fan Y, Kumar RP, Neale G, Kwak YD, McKinnon PJ, Johnson RL, Cao X. The Hippo Pathway Prevents YAP/TAZ–Driven Hypertranscription and Controls Neural Progenitor Number. Developmental Cell  Dec 3;47(5):576-591.e8, 2018. doi: 10.1016/j.devcel.2018.09.021. Epub Oct 25, 2018.

Serinagaoglu Y, Paré J, Giovannini M, Cao X. Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol 398:97-109, 2015.

Lavado A, Ware M, Paré J, Cao X. The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap. Development 141: 4182-93, 2014. Featured in Editor’s Choice, Sci Signal (7) ec305

Lavado A, He Y, Paré J, Neale G, Olson EN, Giovannini M, Cao X. Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development 140: 3323-34, 2013.

Denli AM, Cao X, Gage FH. miR-9 and TLX: chasing tails in neural stem cells. Nat Struct Mol Biol 16:346-347, 2009.

Cao X, Pfaff SL, Gage FH. YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes & Dev 22:3320-3334, 2008.

Cao X, Pfaff SL, Gage FH. A functional study of miR-124 in the developing neural tube. Genes & Dev 21:531-536, 2007.

Cao X, Yeo G, Muotri AR, Kuwabara T, Gage FH. Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci 29:77-103, 2006.

Cao X, Südhof TC. Dissection of amyloid-β precursor protein-dependent transcriptional transactivation. J Biol Chem 279:24601-11, 2004.

Biederer T, Cao X, Südhof TC, Liu X. Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms. J Neurosci 22:7340-51, 2002.

Cao X, Südhof TC. A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293:115-20, 2001.

Last update: January 2019