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St. Jude Children's Research Hospital Home
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St. Jude Family of Websites
Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
- Fundraising
Comprehensive Cancer Center
St. Jude Children’s Research Hospital has the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.
About us
The mission of the St. Jude Comprehensive Cancer Center (SJCCC) is to advance cures for pediatric cancer through research and treatment. We are the nation’s only NCI-designated Cancer Center dedicated exclusively to pediatric cancer.
Our designation as a Comprehensive Cancer Center reflects leading excellence in laboratory, clinical and survivorship research, as well as leadership in education and community outreach. The center has received the highest possible score of “exceptional” in its three most recent NCI reviews.
Director Charles W. M. Roberts, MD, PhD, a long-standing advocate of team science, leads the Center with a strong vision: To bring about a future in which every child with cancer can look forward to a long and healthy life. The Center aims to improve outcomes and understanding of pediatric cancer to benefit patients and survivors in our catchment area, and to extend these findings to the nation and the world.
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The Comprehensive Cancer Center aims to improve outcomes and understanding of pediatric cancer to benefit patients and survivors.
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St. Jude is one of the world’s leading childhood cancer research and treatment centers. Learn how we are helping more children survive and thrive.
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The SJCCC is committed to efforts to develop a well-trained, diverse biomedical workforce and foster the next generation of pediatric cancer researchers
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St. Jude COE works with communities to increase access to cancer care, support survivors, and promote child health, ultimately improving the lives of children.
Leadership
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Charles W. M. Roberts, MD, PhD
Member, St. Jude Faculty
Executive Vice President
Director, Comprehensive Cancer Center
Lillian R. Cannon Comprehensive Cancer Center Director Endowed Chair
Charles W. M. Roberts, MD, PhD
Member, St. Jude Faculty
Executive Vice President
Director, Comprehensive Cancer Center
Lillian R. Cannon Comprehensive Cancer Center Director Endowed Chair
Affiliations
Research Interests
- Understanding the roles of SWI/SNF complex mutations and dysfunctional chromatin remodeling in cancer
- Improving the outcome of children with pediatric cancer
Contact Information
Charles W. M. Roberts, MD, PhD
Comprehensive Cancer Center
MS 281, Room C7045M
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Charles G. Mullighan, MBBS (Hons), MSc, MD
Member, St. Jude Faculty
Senior Deputy Director of Strategic Initiatives, Comprehensive Cancer Center
Co-Leader, Hematological Malignancies Program
Medical Director, St. Jude Biorepository
William E. Evans Endowed Chair
Charles G. Mullighan, MBBS (Hons), MSc, MD
Member, St. Jude Faculty
Senior Deputy Director of Strategic Initiatives, Comprehensive Cancer Center
Co-Leader, Hematological Malignancies Program
Medical Director, St. Jude Biorepository
William E. Evans Endowed Chair
Affiliations
Research Interests
- The use of integrated genomic and epigenomic approaches to understand the pathogenesis and evolution of acute lymphoblastic leukemia (ALL) and related disorders
- Defining the interaction of inherited and somatic genetic alterations in leukemogenesis
- The use of in vitro and in vivo experimental approaches to model genomic abnormalities in leukemogenesis
- Preclinical therapeutic testing to translate genomic discoveries to new treatment approaches in ALL
Contact Information
Charles G. Mullighan, MBBS (Hons), MSc, MD
Pathology
MS 342, Room D4047D
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Suzanne J. Baker, PhD
Member, St. Jude Faculty
Deputy Director, Comprehensive Cancer Center
Co-leader, Neurobiology and Brain Tumor Program
Endowed Chair in Brain Tumor Research
Suzanne J. Baker, PhD
Member, St. Jude Faculty
Deputy Director, Comprehensive Cancer Center
Co-leader, Neurobiology and Brain Tumor Program
Endowed Chair in Brain Tumor Research
Affiliations
Research Interests
- Investigating mechanisms driving diffuse high-grade gliomas (HGGs) in children, including Grade III anaplastic astrocytomas and Grade IV glioblastomas
- Studying unique features of pediatric HGGs, such as anatomical differences and distinct oncogenic mutations compared to adult gliomas
- Identifying subgroups of pediatric HGG based on clinical features and recurrent mutations linked to chromatin regulation and developmental signaling
- Developing improved disease models to study pediatric HGG subgroups and test targeted therapies
Contact Information
Suzanne J. Baker, PhD
Developmental Neurobiology
MS 323, Room M3412
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Senior Leadership
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Heather M. Brandt, PhD
Member, St. Jude Faculty
Director, HPV Cancer Prevention Program
Co-associate Director for Outreach, St. Jude Comprehensive Cancer Center
Heather M. Brandt, PhD
Member, St. Jude Faculty
Director, HPV Cancer Prevention Program
Co-associate Director for Outreach, St. Jude Comprehensive Cancer Center
Affiliations
Research Interests
- Dissemination and implementation science research
- Cancer prevention and control: human papillomavirus (HPV) vaccination and cervical cancer screening
- Partnered- and engaged-approaches to research (community-engaged research)
- Cancer-related health disparities among underserved populations
Contact Information
Heather M. Brandt, PhD
Epidemiology & Cancer Control
MS 762, Room S3005
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Hongbo Chi, PhD
Member, St. Jude Faculty
Chair, Department of Immunology
Robert G. Webster Endowed Chair in Immunology
Co-Director, Center of Excellence for Pediatric Immuno-Oncology (CEPIO)
Associate Director, Basic Research, Comprehensive Cancer Center
Hongbo Chi, PhD
Member, St. Jude Faculty
Chair, Department of Immunology
Robert G. Webster Endowed Chair in Immunology
Co-Director, Center of Excellence for Pediatric Immuno-Oncology (CEPIO)
Associate Director, Basic Research, Comprehensive Cancer Center
Affiliations
Research Interests
- Studying how metabolism influences immune cell fate, including T cells and dendritic cells
- Exploring nutrient signaling pathways in T cell development, quiescence, and differentiation
- Using CRISPR screens to identify targets for improving T cell function and CAR T therapies
- Applying multi-omics tools to uncover immune mechanisms in cancer, autoimmunity, and neurodegeneration
Contact Information
Hongbo Chi, PhD
Immunology
MS 351, Room E7053
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Elizabeth Fox, MD, MS
Member, St. Jude Faculty
Senior Vice President, Clinical Trials Research
Associate Director for Clinical Research, Comprehensive Cancer Center
Elizabeth Fox, MD, MS
Member, St. Jude Faculty
Senior Vice President, Clinical Trials Research
Associate Director for Clinical Research, Comprehensive Cancer Center
Affiliations
Research Interests
- Developmental therapeutics in pediatric oncology
Contact Information
Elizabeth Fox, MD, MS
Clinical Trials Administration
MS 281, Room C7025
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Melissa M. Hudson, MD
Member, St. Jude Faculty
Director, Cancer Survivorship Division
Associate Director, Population Sciences
The Charles E. Williams Endowed Chair of Oncology-Cancer Survivorship
Melissa M. Hudson, MD
Member, St. Jude Faculty
Director, Cancer Survivorship Division
Associate Director, Population Sciences
The Charles E. Williams Endowed Chair of Oncology-Cancer Survivorship
Affiliations
Research Interests
- Disease burden after childhood cancer
- Health status and quality of life after childhood cancer
- Pediatric cancer survivorship care guideline development
Contact Information
Melissa M. Hudson, MD
Cancer Survivorship
MS 735
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Julie R. Park, MD
Member, St. Jude Faculty
Chair, Department of Oncology
Associate Director Comprehensive Cancer Center, Translational Research
Endowed Chair in Pediatric Oncology
Julie R. Park, MD
Member, St. Jude Faculty
Chair, Department of Oncology
Associate Director Comprehensive Cancer Center, Translational Research
Endowed Chair in Pediatric Oncology
Affiliations
Research Interests
- Translational research to improve survival of children with cancer
- Development of cellular immunotherapy trials for pediatric cancer
- Immuno-oncology
- Novel cellular immunotherapy for refractory and recurrent pediatric malignancies
- Neuroblastoma
- New Approaches to Neuroblastoma Therapy
- Novel drug development for high-risk neuroblastoma
Contact Information
Julie R. Park, MD
Oncology
MS 260, Room C6008
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Shondra Pruett-Miller, PhD
Associate Member, St. Jude Faculty
Vice President, Cancer Center Shared Resources
Director, Center for Advanced Genome Engineering
Shondra Pruett-Miller, PhD
Associate Member, St. Jude Faculty
Vice President, Cancer Center Shared Resources
Director, Center for Advanced Genome Engineering
Affiliations
Research Interests
- Genome-editing technologies
- Disease modeling in iPSCs
- Development of preclinical animal models using CRISPR-Cas9
- Development of novel genome editing strategies to treat β-hemoglobinopathies
Contact Information
Shondra Pruett-Miller, PhD
Cell & Molecular Biology
MS 340, Room D5048E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Carlos Rodriguez-Galindo, MD
Member, St. Jude Faculty
Executive Vice President
Chair, Department of Global Pediatric Medicine
Director, St. Jude Global
Co-Associate Director, Outreach, Comprehensive Cancer Center
Four Stars of Chicago Endowed Chair in International Pediatric Outreach
Carlos Rodriguez-Galindo, MD
Member, St. Jude Faculty
Executive Vice President
Chair, Department of Global Pediatric Medicine
Director, St. Jude Global
Co-Associate Director, Outreach, Comprehensive Cancer Center
Four Stars of Chicago Endowed Chair in International Pediatric Outreach
Affiliations
Research Interests
- Global medicine
- Pediatric solid tumors
Contact Information
Carlos Rodriguez-Galindo, MD
Global Pediatric Medicine
MS 721, Room S2015
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Dana Wallace, MS
Associate Director for Administration, Comprehensive Cancer Center
Dana Wallace, MS
Associate Director for Administration, Comprehensive Cancer Center
Affiliations
Contact Information
Dana Wallace, MS
Cancer Center Administration
MS 281, Room C7045A
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Gerard P. Zambetti, PhD
Member, St. Jude Faculty
Associate Director, Education and Training, Comprehensive Cancer Center
Gerard P. Zambetti, PhD
Member, St. Jude Faculty
Associate Director, Education and Training, Comprehensive Cancer Center
Affiliations
Research Interests
- Function of wild-type and mutant p53 in tumor suppression and oncogenesis
- Regulation of cell cycle, cell survival and differentiation
- The biology of pediatric adrenocortical carcinoma
Contact Information
Gerard P. Zambetti, PhD
Pathology
MS 276, Room D5006B
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Research Program Leaders
Cancer Biology
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Douglas Green, PhD
Member, St. Jude Faculty
Co-Leader, Cancer Biology Program
Peter C. Doherty Endowed Chair of Immunology
Douglas Green, PhD
Member, St. Jude Faculty
Co-Leader, Cancer Biology Program
Peter C. Doherty Endowed Chair of Immunology
Affiliations
Research Interests
- Central mechanisms of apoptosis in cancer and the immune system
Contact Information
Douglas Green, PhD
Immunology
MS 351, Room E7050
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Richard Kriwacki, PhD
Member, St. Jude Faculty
Co-Leader, Cancer Biology Program
Adjunct Associate Professor, Department of Molecular Sciences, UT Health Science Center, Memphis
Richard Kriwacki, PhD
Member, St. Jude Faculty
Co-Leader, Cancer Biology Program
Adjunct Associate Professor, Department of Molecular Sciences, UT Health Science Center, Memphis
Affiliations
Research Interests
- Regulation of cell division, apoptosis and ribosome biogenesis
- Intrinsically disordered proteins, including p21- and p27-mediated regulation of Cdks that control cell division
- Molecular mechanisms by which cytosolic p53 regulates intrinsic apoptosis
- Phase separation in nucleolar structure, function and dynamics and how this relates to neurodegenerative diseases
Contact Information
Richard Kriwacki, PhD
Structural Biology
MS 311, Room M7434
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Cancer Control and Survivorship
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Greg Armstrong, MD, MSCE
Member, St. Jude Faculty
Chair, Department of Epidemiology and Cancer Control
Co-Leader, Cancer Control & Survivorship Program
Endowed Chair in Epidemiology & Cancer Control
Greg Armstrong, MD, MSCE
Member, St. Jude Faculty
Chair, Department of Epidemiology and Cancer Control
Co-Leader, Cancer Control & Survivorship Program
Endowed Chair in Epidemiology & Cancer Control
Affiliations
Research Interests
- Childhood Cancer Survivor Study (CCSS), Principal Investigator
- Longitudinal Cardiotoxicity in Adult Survivors of Childhood Cancer (R01, NIH), Principal Investigator
- Encouraging Mammography and Preventive Opportunities for Women Exposed to Radiation, Co-Investigator
- Reducing Skin Cancer in Childhood Cancer Survivors, Co-Investigator
- Adult Neurobehavioral Late Effects of Pediatric Low Grade Brain Tumors, Co-Investigator
Contact Information
Greg Armstrong, MD, MSCE
Epidemiology and Cancer Control
MS 735
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Kirsten K. Ness, PT, PhD, FAPTA
Member, St. Jude Faculty
Principal Investigator, Human Performance Lab
Co-Leader, Cancer Control and Survivorship Program
Endowed Chair in Cancer Survivorship
Kirsten K. Ness, PT, PhD, FAPTA
Member, St. Jude Faculty
Principal Investigator, Human Performance Lab
Co-Leader, Cancer Control and Survivorship Program
Endowed Chair in Cancer Survivorship
Affiliations
Research Interests
- Clinical and population measurement of physical performance and disability
- Exercise, physical activity and dietary intervention to prevent and remediate frail health
- Accelerated aging in cancer survivors
- Analysis of epidemiologic data
- Cardiac rehabilitation
Contact Information
Kirsten K. Ness, PT, PhD, FAPTA
Epidemiology and Cancer Control
MS 735
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Developmental Biology and Solid Tumor
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Michael A. Dyer, PhD
Member, St. Jude Faculty
Chair, Developmental Neurobiology Department
Co-Leader, Cancer Center Developmental Biology and Solid Tumor Program
Richard C. Shadyac Endowed Chair in Pediatric Cancer Research
Investigator, Howard Hughes Medical Institute
Michael A. Dyer, PhD
Member, St. Jude Faculty
Chair, Developmental Neurobiology Department
Co-Leader, Cancer Center Developmental Biology and Solid Tumor Program
Richard C. Shadyac Endowed Chair in Pediatric Cancer Research
Investigator, Howard Hughes Medical Institute
Affiliations
Research Interests
- Coordination of proliferation and differentiation during neurogenesis
- Retinal disease and stem cell based therapies
- Retinoblastoma and targeted chemotherapy
- Pediatric solid malignancies
- High throughput screening and drug discovery
- Genomics and epigenomics of pediatric solid tumors
Contact Information
Michael A. Dyer, PhD
Developmental Neurobiology
MS 324, Room D2039
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Alberto Pappo, MD
Member, St. Jude Faculty
Co-Leader, Developmental Biology & Solid Tumor Program
Alvin Mauer Endowed Chair
Alberto Pappo, MD
Member, St. Jude Faculty
Co-Leader, Developmental Biology & Solid Tumor Program
Alvin Mauer Endowed Chair
Affiliations
Research Interests
Development of novel therapies for pediatric solid tumors with special interest in:
- Pediatric melanoma
- Soft tissue sarcomas
- Pediatric gastrointestinal stromal tumors
Contact Information
Alberto Pappo, MD
Solid Tumor
MS 260, Room C6017
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Hematological Malignancies
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Charles G. Mullighan, MBBS (Hons), MSc, MD
Member, St. Jude Faculty
Senior Deputy Director of Strategic Initiatives, Comprehensive Cancer Center
Co-Leader, Hematological Malignancies Program
Medical Director, St. Jude Biorepository
William E. Evans Endowed Chair
Charles G. Mullighan, MBBS (Hons), MSc, MD
Member, St. Jude Faculty
Senior Deputy Director of Strategic Initiatives, Comprehensive Cancer Center
Co-Leader, Hematological Malignancies Program
Medical Director, St. Jude Biorepository
William E. Evans Endowed Chair
Affiliations
Research Interests
- The use of integrated genomic and epigenomic approaches to understand the pathogenesis and evolution of acute lymphoblastic leukemia (ALL) and related disorders
- Defining the interaction of inherited and somatic genetic alterations in leukemogenesis
- The use of in vitro and in vivo experimental approaches to model genomic abnormalities in leukemogenesis
- Preclinical therapeutic testing to translate genomic discoveries to new treatment approaches in ALL
Contact Information
Charles G. Mullighan, MBBS (Hons), MSc, MD
Pathology
MS 342, Room D4047D
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Sarah Elitzur, MD
Member, St. Jude Faculty
Director, Leukemia/Lymphoma Division
Co-Leader, Hematological Malignancies Program
Sarah Elitzur, MD
Member, St. Jude Faculty
Director, Leukemia/Lymphoma Division
Co-Leader, Hematological Malignancies Program
Affiliations
Research Interests
- New therapeutic approaches to childhood acute leukemias
- High-risk subgroups of childhood ALL
- Tailored treatment strategies for hematological malignancies in patients with genetic predisposition disorders
- Histiocytic disorders
Contact Information
Sarah Elitzur, MD
Oncology
MS 260, Room C6072
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Neurobiology and Brain Tumor
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Suzanne J. Baker, PhD
Member, St. Jude Faculty
Deputy Director, Comprehensive Cancer Center
Co-leader, Neurobiology and Brain Tumor Program
Endowed Chair in Brain Tumor Research
Suzanne J. Baker, PhD
Member, St. Jude Faculty
Deputy Director, Comprehensive Cancer Center
Co-leader, Neurobiology and Brain Tumor Program
Endowed Chair in Brain Tumor Research
Affiliations
Research Interests
- Investigating mechanisms driving diffuse high-grade gliomas (HGGs) in children, including Grade III anaplastic astrocytomas and Grade IV glioblastomas
- Studying unique features of pediatric HGGs, such as anatomical differences and distinct oncogenic mutations compared to adult gliomas
- Identifying subgroups of pediatric HGG based on clinical features and recurrent mutations linked to chromatin regulation and developmental signaling
- Developing improved disease models to study pediatric HGG subgroups and test targeted therapies
Contact Information
Suzanne J. Baker, PhD
Developmental Neurobiology
MS 323, Room M3412
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Giles W. Robinson, MD
Member, St. Jude Faculty
Director, Division of Neuro-Oncology
Co-Leader, Cancer Center Neurobiology and Brain Tumor Program
Giles W. Robinson, MD
Member, St. Jude Faculty
Director, Division of Neuro-Oncology
Co-Leader, Cancer Center Neurobiology and Brain Tumor Program
Affiliations
Research Interests
- Improve survival and reduce the morbidity of children with central nervous system tumors
- Genomic analysis of medulloblastoma and other central nervous system tumors
- Tumor biology
Contact Information
Giles W. Robinson, MD
Neuro Oncology
MS 260, Room C6069
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
An NCI-Designated Cancer Center
NCI-designation as a comprehensive cancer center is a prestigious recognition awarded by the National Cancer Institute to institutions that demonstrate excellence in cancer research, treatment, prevention, and education. These centers are at the forefront of scientific discovery, translating cutting-edge research into advanced clinical care. They offer patients access to the latest therapies and clinical trials not widely available elsewhere. NCI-designated centers also play a crucial role in training the next generation of cancer researchers and clinicians, ensuring a continued commitment to reducing the burden of cancer through innovation and comprehensive care.
Join us
St. Jude investigators have the freedom to focus on making big discoveries, backed by extraordinary resources and support teams. We are always looking for highly motivated scientists and engineers with passion and talent to join us!