Jason Cheng-Hsuan Chiang, MD, PhD
Jason Cheng-Hsuan Chiang, MD, PhD

Jason Cheng-Hsuan Chiang, MD, PhD

Assistant Member, St. Jude Faculty



PhD – Johns Hopkins University School of Medicine, Baltimore, Maryland
MD – National Taiwan University School of Medicine, Taipei, Taiwan

Honors & Awards

  • 2015 American Association of Neuropathologists Travel Award
  • 2015 Pathology Postdoctoral Research Training Program Award, University of Pittsburgh School of Medicine Department of Pathology
  • 2010 Maryland Stem Cell Research Fund Post-Doctoral Fellowship
  • 2009 American Heart Association Predoctoral Fellowship
  • 2005 Taiwan Merit Scholarship

Research Interests

  • Diagnosis and classification of pediatric central nervous system neoplasms
  • Molecular drivers and markers of pediatric central nervous system neoplasms

Selected Publications

Chiang J, Diaz AK, Makepeace L, Li X, Han Y, Li Y, Klimo P Jr, Boop FA, Baker SJ, Gajjar A, Merchant TE, Ellison DW, Broniscer A, Patay Z, Tinkle CL. Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG. Acta Neuropathol Commun 8(1):57, 2020. 

Chiang J, Li X, Liu APY, Qaddoumi I, Acharya S, Ellison DW. Tectal glioma harbors high rates of KRAS G12R and concomitant KRAS and BRAF alterations. Acta Neuropathol 39(3):601-602, 2020.

Sievers P, Chiang J, Schrimpf D, Stichel D, Paramasivam N, Sill M, Gayden T, Casalini B, Reuss DE, Dalton J, Pajtler KW, Hänggi D, Herold-Mende C, Rushing E, Korshunov A, Mawrin C, Weller M, Schlesner M, Wick W, Jabado N, Jones DTW, Pfister SM, von Deimling A, Ellison DW, Sahm F. YAP1-fusions in pediatric NF2-wildtype meningioma. Acta Neuropathol 139(1):215-218, 2020.

Carey SS, Sadighi Z, Wu S, Chiang J, Robinson GW, Ghazwani Y, Liu APY, Acharya S, Merchant TE, Boop FA, Gajjar A, Qaddoumi I. Evaluating pediatric spinal low-grade gliomas: a 30-year retrospective analysis. J Neurooncol 145(3):519-529, 2019.

Chiang J, Harreld JH, Tinkle CL, Moreira DC, Li X, Acharya S, Qaddoumi I, Ellison DW. A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration. Acta Neuropathologica 138(6):1091-1092, 2019.

Chiang J, Harreld JH, Tanaka R, Li X, Wen J, Zhang C, Boué DR, Rauch TM, Boyd JT, Chen J, Corbo JC, Bouldin TW, Elton SW, Liu LL, Schofield D, Lee SC, Bouffard JP, Georgescu MM, Dossani RH, Aguiar MA, Sances RA, Saad AG, Boop FA, Qaddoumi I, Ellison DW. Septal dysembryoplastic neuroepithelial tumor: a comprehensive clinical, imaging, histopathologic, and molecular analysis. Neuro-Oncology 21(6):800-808, 2019.

Heitzer AM, Ashford JM, Hastings C, Liu APY, Wu S, Bass JK, Vestal R, Hoehn M, Chiang J, Ghazwani Y, Acharya S, Boop F, Gajjar A, Merchant TE, Qaddoumi I, Conklin HM.  Neuropsychological outcomes of patients with low-grade glioma diagnosed during the first year of life. Journal of Neuro-Oncology 141(2):413-420, 2019.

Chiang J, Dalton J, Upadhyaya SA, Patay Z, Qaddoumi I, Li X, Segura AD, Sharma S, Ismail A, Shurtleff SA, Raimondi SC. Chromosome arm 1q gain is an adverse prognostic factor in localized and diffuse leptomeningeal glioneuronal tumors with BRAF gene fusion and 1p deletion. Acta Neuropathologica 137(1):179-181, 2019.

Xu K, Ding L, Chang TC, Shao Y, Chiang J, Mulder H, Wang S, Shaw TI, Wen J, Hover L, McLeod C, Wang YD, Easton J, Rusch M, Dalton J, Downing JR, Ellison DW, Zhang J, Baker SJ, Wu G. Structure and evolution of double minutes in diagnosis and relapsebrain tumors. Acta Neuropathologica 137(1):123-137, 2019.

Liu APY, Harreld JH, Jacola LM, Gero M, Acharya S, Ghazwani Y, Wu S, Li X, Klimo P, Gajjar A, Chiang J, Qaddoumi I. Tectal glioma as a distinct diagnostic entity:a comprehensive clinical, imaging,histologic and molecular analysis. Acta Neuropathologica Communications  6:101, 2018.

Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU, Monoranu CM, Milde T, Wittmann A, Hartmann C, Sommer C, Paulus W, Gärtner J, Brück W, Rüdiger T, Leipold A, Jaunmuktane Z, Brandner S, Giangaspero F, Nozza P, Mora J, Morales la Madrid A, Cruz Martinez O, Hansford JR, Pietsch T, Tietze A, Hernáiz-Driever P, Stoler I, Capper D, Korshunov A, Ellison DW, von Deimling A, Pfister SM, Sahm F, Jones DTW.  Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features. Acta Neuropathologica 136(2):239-253, 2018.  

Ghazwani Y, Qaddoumi I, Bass JK, Wu S, Chiang J, Boop F, Gajjar A, Sadighi Z (2017) Profound hearing loss following surgery in pediatric patients with posterior fossa low-grade glioma. Neuro-Oncology Practice Dec 18, 2017.

Chiang CH, Harreld JH, Orr BA, Sharma S, Ismail A, Segura AD, Ellison DW. Low-grade spinal glioneuronal tumors with BRAF gene fusion and 1p deletion but without leptomeningeal dissemination. Acta Neuropathologica July;134(1):159-62, 2017.

Chiang CH, Ellison DW. Molecular Pathology of Pediatric Central Nervous System Tumors. Journal of Pathology Jan; 241(2):159-172, 2017.

Bissel SJ, Auer R, Chiang CH, Kofler J, Murdoch GH, Nix WA, Painter M, Richer M, Startelet H, Wang G, Wiley CA. Human Parechovirus 3 Meningitis and Fatal Leukoencephalopathy. Journal of Neuropathology & Experimental Neurology Aug;74(8):767-77, 2015.

Chiang CH, Chu CT, Wiley CA. A 67 Year-Old Man with Multiple Sclerosis and New Cerebellar Lesions. Brain Pathol Jul;25(4):507-8, 2015.

Wen Z, Nguyen HN, Guo Z, Lalli MA, Wang X, Su Y, Kim NS, Yoon KJ, Shin J, Zhang C, Makri G, Nauen D, Yu H, Guzman E, Chiang CH, Yoritomo N, Kaibuchi K, Zou J, Christian KM, Cheng L, Ross CA, Margolis RL, Chen G, Kosik KS, Song H, Ming GL. Synaptic dysregulation in a human iPS cell model of mental disorders. Nature Nov 20;515(7527):414-8, 2014

Wang HC, Lu CH, Cheng KI, Chiang CH. Inflammatory reaction in neurological diseases. Biomed Res Int 2014:408514, 2014.

HD iPSC Consortium. Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11(2):264-78, 2012.

Juopperi TA, Kim WR, Chiang CH, Yu H, Margolis RL, Ross CA, Ming GL, Song H. Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells. Molecular Brain 5(1):17-30, 2012.

Chiang CH, Su Y, Wen Z, Yoritomo N, Ross CA, Margolis RL, Song H, Ming GL. Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation. Mol Psychiatry Apr;16(4):358-60, 2011. Epub 2011 Feb 22. Cover of the issue.

Ma DK, Chiang CH, Ponnusamy K, Ming GL, Song H. G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells 26(8):2131-41, 2008. Epub 2008 Jun 5.

Chao CC, Chiang CH, Ma YL, Lee EH. Molecular mechanism of the neurotrophic effect of GDNF on DA neurons: role of protein kinase CK2. Neurobiology of Aging 27(1):105-18, 2006.

Last update: April 2020

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