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Angela Delaney, MD
Angela Delaney, MD

Angela Delaney, MD

Assistant Member, St. Jude Faculty

  • Director, Division of Endocrinology

Departments

Divisions

Education

Pediatric Endocrinology Fellowship - Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD
Pediatric Residency - Schneider Children’s Hospital, North Shore-Long Island Jewish Health System, New Hyde Park, NY
MD - The George Washington University School of Medicine and Health Sciences, Washington, DC
BS (Biology) - The George Washington University, Washington, DC

Research Interests

  • Hypothalamic/pituitary consequences of childhood cancer and its therapy
  • Genetic determinants of susceptibility to late effects of childhood cancer therapy
  • Pubertal disorders and their molecular causes

Selected Publications

Whitman MC, Barry BJ, Robson CD, Facio FM, Van Ryzin C, Chan WM, Lehky TJ, Thurm A, Zalewski C, King KA, Brewer C, Almpani K, Lee JS, Delaney A, FitzGibbon EJ, Lee PR, Toro C, Paul SM, Abdul-Rahman OA, Webb BD, Jabs EW, Moller HU, Larsen DA, Antony JH, Troedson C, Ma A, Ragnhild G, Wirgenes KV, Tham E, Kvarnung M, Maarup TJ, MacKinnon S, Hunter DG, Collins FS, Manoli I, Engle EC. TUBB3 Arg262His causes a recognizable syndrome including CFEOM3, facial palsy, joint contractures, and early-onset peripheral neuropathy. Hum Genet Oct 15, 2021.

Chemaitilly W, Li Z, Brinkman TM, Delaney A, Huang S, Bjornard KL, Lam CG, Wilson CL, Barnes N, Clark KL, Krasin MJ, Metzger ML, Sheyn A, Bishop MW, Sabin ND, Howell RM, Helmig S, Shulkin BL, Triplett BM, Pui CH, Gajjar A, Srivastava DK, Green DM, Armstrong GT, Robison LL, Hudson MM, Ness KK, Sklar CA, Krull KR. Primary hypothyroidism in childhood cancer survivors: Prevalence, risk factors, and long-term consequences. Cancer Oct 13, 2021.

Song N, Liu Q, Wilson CL, Sapkota Y, Ehrhardt MJ, Gibson TM, Morton LM, Chanock SJ, Neglia JP, Arnold MA, Michael JR, Gout AM, Mulder HL, Easton J, Bhatia S, Armstrong GT, Zhang J, Delaney A, Hudson MM, Robison LL, Yasui Y, Wang Z. Polygenic risk score improves risk stratification and prediction of subsequent thyroid cancer after childhood cancer. Cancer Epidemiol Biomarkers Prev Aug 31, 2021.

Delaney A, Howell CR, Krull KR, Brinkman TM, Armstrong GT, Chemaitilly W, Wilson CL, Mulrooney DA, Wang Z, Lanctot JQ, Johnson RE, Krull MR, Partin RE, Shelton KC, Srivastava DK, Robison LL, Hudson MM, Ness KK.  Progression of frailty in survivors of childhood cancer: a St. Jude Lifetime Cohort report. J Natl Cancer Inst March 15, 2021. https://doi.org/10.1093/jnci/djab033

Rojas RA, Kutateladze A, Plummer L, Stamou M, Keefe DL, Salnikov KB, Delaney A, Hall JE, Sadreyev R, Ji F, Fliers E, Gambosova K, Quinton R, Merino PM, Mericq V, Seminara SB, Crowley WF, Balasubramanian R.  Phenotypic continuum between Waardenburg syndrome and Idiopathic Hypogonadotropic Hypogonadism in humans with SOX10 mutations.  Genet Med ePub ahead of print Jan 13, 2021. https://doi.org/10.1038/s41436-020-01051-3

Berthon A, Settas N, Delaney A, Giannakou A, Demidowich A, Rueda Faucz F, Seminara SB, Chen M, Stratakis CA.  Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion.  Human Molecular Genetics Dec 18; 29(20), 3443-3450, 2020.  https://doi.org/10.1093/hmg/ddaa215

Delaney A, Burkholder AB, Lavender CA, Plummer L, Mericq MV, Merino PM, Quinton R, Lewis KL, Meader B, Albano A, Shaw ND, Welt CK, Martin KA, Seminara SB, Biesecker LG, Bailey-Wilson JE., Hall JE.  Increased Burden of Rare Sequence Variants in GnRH-Associated Genes in Women with Hypothalamic Amenorrhea. J Clin Endocrinol Metab March; 106(3):e1441-e1452, 2021. https://doi.org/10.1210/clinem/dgaa609

Meader BN, Albano A, Sekizkardes H, Delaney A. Heterozygous deletions in MKRN3 cause central precocious puberty without Prader-Willi Syndrome. J Clin Endocrinol Metab Aug; 105(8):1-8, 2020. https://doi.org/10.1210/clinem/dgaa331.

Shirazi TN, Selfa H, Dawood K, Cárdenasb R, Welling LLM, Rosenfield KA, Ortiz TL, Carré JM, Balasubramanian R, Delaney A, Crowley WF Jr, Breedlove SM, Puts DA.  Pubertal timing predicts adult psychosexuality: Evidence from typically developing adults and adults with isolated GnRH deficiency.  Psychoneuroendocrinology Sept; 199:104733, 2020. https://doi.org/10.1016/j.psyneuen.2020.104733

Delaney A, Volochayev R, Meader B, Lee J, Almpani K, Noukelak GY, Henkind J, Chalmers L, Law JR, Williamson KA, Jacobsen CM, Buitrago TP, Perez O, Cho CH, Kaindl A, Rauch A, Steindl K, Garcia JE, Russel BE, Prasad R, Mondal UK, Reigstad HM, Clements S, Kim S, Inoue K, Arora G, Salnikov KB, DiOrio NP, Prada R, Capri Y, Morioka K, Mizota M, Zechi-Ciede RM, Kokitsu-Nakata NM, Tonello C, Vendramini-Pittoli S, da Silva Dalben G, Balasubramanian R, Dwyer AA, Seminara SB, Crowley Jr WF, Plummer L, Hall JE, Graham Jr JM, Lin AE, and Shaw, ND. Insight into the Ontogeny of GnRH Neurons from Patients Born Without a Nose. J Clin Endocrinol Metab May; 105(5): 1538-1551, 2020.

Jee YH, Won S, Lui JC, Jennings M, Whalen P, Yue S, Temnycky A, Barnes KM, Cheetham T, Boden MG, Radovick S, Quinton R, Leschek EW, Aguilera G, Yanovski JA, Seminara SB, Crowley, Jr. WF, Delaney A, Roche KW, Baron J.  DLG2 variants in patients with pubertal disorders.  Genet Med 22:1329-1337, 2020. https://doi.org/10.1038/s41436-020-0803-8  

Shirazi TN, Self H, Cantor J, Dawood K, Cárdenas R, Resenfield K, Ortiz T, Carré J, McDaniel MA, Blanchard R, Balasubramanian R, Delaney A, Crowley WF Jr, Breedlove SM, Puts D, et al. Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples. Hormones and Behavio. May; 104712, 2020.  

Meader BN, Albano A, Sekizkardes H, Delaney A. Heterozygous deletions in MKRN3 cause central precocious puberty without Prader-Willi Syndrome. J Clin Endocrinol Metab. Aug 1;105(8):dgaa331, 2020. doi: 10.1210/clinem/dgaa331.

Lippincott MF, Nguyen K, Delaney A, Chan YM, Seminara SB. Assessing Sex-Steroid Influence on Kisspeptin Responsiveness in Idiopathic Hypogonadotropic Hypogonadism. J Endocr Soc Sep 20;2(11):1293-1305, 2018.

Lippincott MF, Chan YM, Delaney A, Morales DR, Butler JP, Seminara SB. Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty. J Clin Endocrinol Metab Aug;101(8):3061-9, 2016.

Delaney A, Padmanabhan V, Rezvani G, Chen W, Forcinito P, Cheung CSF, Baron J, Lui JCK. Evolutionary conservation and modulation of a juvenile growth-regulating genetic program. J Mol Endocrinol 52(3):269-77, 2014.

Delaney A, Pellizzari M, Speiser PW, Frank GR. Pitfalls in the Measurement of the Nocturnal Blood Pressure Dip in Adolescents with Type 1 Diabetes. Diabetes Care 32(1):165-168, 2009.

Last update: November 2021