Fabio Demontis, PhD
Fabio Demontis, PhD

Fabio Demontis, PhD

Assistant Member, St. Jude Faculty



Laurea (MSc) – Medical School, University of Milano, Italy
PhD – Max Planck Institute for Cell Biology and Genetics, Dresden, Germany
Postdoctoral Studies – Harvard Medical School/HHMI, Boston, Massachusetts

Honors & Awards

  • 2017  Hartwell Foundation Individual Biomedical Research Award
  • 2015  Glenn Award for Research in Biological Mechanisms of Aging
  • 2013  New Scholar in Aging Award, Ellison Medical Foundation
  • 2011  AFAR/GE Healthcare Junior Investigator Award for Excellence in Imaging and Aging Research
  • 2010  Ellison Medical Foundation/AFAR postdoctoral fellowship
  • 2006  European Doctorate in Biotechnologies

Research Interests

  • Role of proteostasis and stress responses in skeletal muscle aging
  • Systemic signaling via muscle-derived secreted factors (myokines) during aging and age-related diseases 

Selected Publications

Jiao J, Demontis F. Skeletal muscle autophagy and its role in sarcopenia and organismal aging. Current Opinion in Pharmacology 34:1-6, 2017.

Parkhitko AA, Binari R, Zhang N, Asara JM, Demontis F, Perrimon N. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Genes & Development Jun 15;30(12):1409-22, 2016.

Hunt LC, Xu B, Finkelstein D, Fan Y, Carroll PA, Cheng P, Eisenman RN, Demontis F. The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling. Genes & Development Dec 1;29(23):2475-89, 2015.

Rai M, Demontis F. Systemic nutrient and stress signaling via myokines and myometabolites. Annual Review of Physiology Feb 78:6.1-6.23, 2016.

Demontis F, Patel VK, Swindell WR, Perrimon N. Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Cell Reports  June 12;7(5):1481-1494, 2014.

Demontis F, Piccirillo R, Goldberg AL, Perrimon N. The influence of skeletal muscle on systemic aging and lifespan. Aging Cell  Dec;12(6):943-9, 2013.

Demontis F, Piccirillo R, Goldberg AL, Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Disease Models & Mechanisms  Nov;6(6):1339-52, 2013.

Katewa SD, Demontis F, Kolipinski M, Hubbard A, Gill MS, Perrimon N, Melov S, Kapahi P. Intra-myocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metabolism Jul 3;16(1):97-103, 2012.

Demontis F, Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell  Nov 24;143(5):813-25, 2010.

Demontis F, Perrimon N. Integration of InR/FOXO signaling and dMyc activity during muscle growth regulates body size. Development  Mar;136(6):983-93, 2009.

Last update: April 2017