Fabio Demontis, PhD
Fabio Demontis, PhD

Fabio Demontis, PhD

Assistant Member, St. Jude Faculty




Laurea (MSc) – Medical School, University of Milano, Italy
PhD – Max Planck Institute for Cell Biology and Genetics, Dresden, Germany
Postdoctoral Studies – Harvard Medical School/HHMI, Boston, Massachusetts

Honors & Awards

  • 2013  New Scholar in Aging Award, Ellison Medical Foundation
  • 2011  AFAR/GE Healthcare Junior Investigator Award for Excellence in Imaging and Aging Research
  • 2010  Ellison Medical Foundation/AFAR postdoctoral fellowship
  • 2006  European Doctorate in Biotechnologies

Research Interests

  • Role of protein homeostasis and stress sensing in skeletal muscle aging
  • Mechanisms controlling skeletal muscle mass and function during aging and age-related diseases
  • Interconnection of muscle and systemic aging via myokine signaling
  • Intertissue communication during aging
  • Drosophila models of human disease

Selected Publications

Patel VK, Demontis F. GDF11/Myostatin and aging. Aging May;6(5):351-352, 2014.

Demontis F, Patel VK, Swindell WR, Perrimon N. Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Cell Reports June 12;7(5):1481-1494, 2014.

Piccirillo R, Demontis F, Perrimon N, Goldberg AL. Mechanisms of muscle growth and atrophy in mammals and Drosophila. Developmental Dynamics June;7(5):1-14, 2014.

Hunt LC, Demontis F. Whole-mount immunostaining of Drosophila skeletal muscle. Nature Protocols Dec;8(12):2496-501, 2013.

Demontis F, Piccirillo R, Goldberg AL, Perrimon N. The influence of skeletal muscle on systemic aging and lifespan. Aging Cell Dec;12(6):943-9, 2013.

Demontis F, Piccirillo R, Goldberg AL, Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Disease Modelels & Mechanisms Nov;6(6):1339-52, 2013.

Katewa SD, Demontis F, Kolipinski M, Hubbard A, Gill MS, Perrimon N, Melov S, Kapahi P. Intra-myocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metabolism Jul 3;16(1):97-103, 2012.

Demontis F, Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell Nov 24;143(5):813-25, 2010.

Demontis F, Perrimon N. Integration of InR/FOXO signaling and dMyc activity during muscle growth regulates body size. Development Mar;136(6):983-93, 2009.

Last update: June 2014