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Fabio Demontis, PhD
Fabio Demontis, PhD


Laurea (MSc) – Medical School, University of Milano, Italy
PhD – Max Planck Institute for Cell Biology and Genetics, Dresden, Germany
Postdoctoral Studies – Harvard Medical School/HHMI, Boston, Massachusetts

Honors & Awards

  • 2017  Hartwell Foundation Individual Biomedical Research Award
  • 2015  Glenn Award for Research in Biological Mechanisms of Aging
  • 2013  New Scholar in Aging Award, Ellison Medical Foundation
  • 2011  AFAR/GE Healthcare Junior Investigator Award for Excellence in Imaging and Aging Research
  • 2010  Ellison Medical Foundation/AFAR postdoctoral fellowship
  • 2006  European Doctorate in Biotechnologies

Research Interests

  • Role of proteostasis and stress responses in skeletal muscle aging
  • Systemic signaling via muscle-derived secreted factors (myokines) during aging and age-related diseases 

Selected Publications

Hunt LC, Pagala V, Stephan A, Xie B, Kodali K, Kavdia K, Wang Y-D, Shirinifard A, Curley M, Graca FA, Fu Y, Poudel S, Li Y, Wang X, Tan H, Peng J, Demontis F. An adaptive stress response that confers cellular resilience to decreased ubiquitination. Nature Communications Nov 14;(14)1:7348, 2023.

Graca FA, Stephan A, Minden-Birkenmaier BA, Shirinifard A, Wang Y-D, Demontis F*, and Labelle M*. Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles. Nature Communications May 22;(14)1:2900, 2023. 

Jiao J, Curley M, Graca FA, Robles-Murguia M, Shirinifard A, Finkelstein D, Xu B, Fan Y, Demontis F. Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging. Cell Reports Jan 31;42(1):111970, 2023.

Graca FA, Stephan A, Wang Y-D, Shirinifard A, Jiao J, Vogel P, Labelle M, Demontis F. Progressive development of melanoma-induced cachexia differentially impacts organ systems in mice. Cell Reports Jan 31;42(1):111934, 2023. 

Graca FA, Rai M, Hunt LC, Stephan A, Wang Y-D, Gordon B, Wang R, Quarato G, Xu B, Fan Y, Labelle M, Demontis F. The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy. Nature Communications May 2;13(1):2370, 2022.

Hunt LC, Graca FA, Pagala V, Wang Y-D, Li Y, Yuan Z-F, Fan Y, Labelle M, Peng J, Demontis F. Integrated genomic and proteomic analyses identify stimulus-dependent molecular changes associated with distinct modes of skeletal muscle wasting. Cell Reports Nov 9;37(6):109971, 2021. 

Graca FA, Sheffield N, Puppa M, Finkelstein D, Hunt LC, Demontis F. A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in DrosophilaPLoS Genetics Nov 15;17(11):e1009926, 2021. 

Rai M, Coleman Z, Curley M, Nityanandam A, Platt A, Robles-Murguia M, Jiao J, Finkelstein D, Wang Y-D, Xu B, Fan Y, Demontis F. Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging. Cell Metabolism Mar 23:S1550-4131(21)00112-1, 2021.

Hunt LC, Schadeberg B, Stover J, Haugen B, Pagala V, Wang Y-D, Puglise J, Barton ER, Peng J, Demontis F. Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging. Nature Communications Mar 3;12(1):1418, 2021.

Robles-Murguia M, Rao D, Finkelstein D, Xu B, Fan Y, Demontis F. Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis. Genes & Development Jan 1;34(1-2):37-52, 2020. 

Hunt LC, Stover J, Haugen B, Shaw TI, Li Y, Pagala VR, Finkelstein D, Barton ER, Fan Y, Labelle M, Peng J, Demontis F. A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice. Cell Reports 28(5):1268-1281, 2019.

Hunt LC, Jiao J, Wang YD, Finkelstein D, Rao D, Curley M, Robles-Murguia M, Shirinifard A, Pagala VR, Peng J, Fan Y, Demontis F. Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations. Genome Research 29(8):1262-1276, 2019.

Parkhitko AA, Binari R, Zhang N, Asara JM, Demontis F, Perrimon N. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Genes & Development Jun 15;30(12):1409-22, 2016.

Hunt LC, Xu B, Finkelstein D, Fan Y, Carroll PA, Cheng P, Eisenman RN, Demontis F. The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling. Genes & Development Dec 1;29(23):2475-89, 2015.

Rai M, Demontis F. Systemic nutrient and stress signaling via myokines and myometabolites. Annual Review of Physiology Feb 78:6.1-6.23, 2016.

Demontis F, Patel VK, Swindell WR, Perrimon N. Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Cell Reports  June 12;7(5):1481-1494, 2014.

Katewa SD, Demontis F, Kolipinski M, Hubbard A, Gill MS, Perrimon N, Melov S, Kapahi P. Intra-myocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metabolism Jul 3;16(1):97-103, 2012.

Demontis F, Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell  Nov 24;143(5):813-25, 2010.

Demontis F, Perrimon N. Integration of InR/FOXO signaling and dMyc activity during muscle growth regulates body size. Development  Mar;136(6):983-93, 2009.

Last update: November 2023