Selected Publications
Bhattarai KR, Mobley RJ, Barnett KR, Ferguson DC, Hansen BS, Diedrich JD, Bergeron BP, Yoshimura S, Yang W, Crews KR, Manring CS, Jabbour E, Paietta E, Litzow MR, Kornblau SM, Stock W, Inaba H, Jeha S, Pui CH, Cheng C, Pruett-Miller SM, Relling MV, Yang JJ, Evans WE, Savic D. Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment. Nat Commun 2024 May 1;15(1):3681. doi:10.1038/s41467-024-48124-4. PMID: 38693155; PMCID: PMC11063049
Lee SHR, Yang W, Gocho Y, John A, Rowland L, Smart B, Williams H, Maxwell D, Hunt J, Yang W, Crews KR, Roberts KG, Jeha S, Cheng C, Karol SE, Relling MV, Rosner GL, Inaba H, Mullighan CG, Pui CH, Evans WE, Yang JJ. Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response. Nat Med 2023 Jan;29(1):170-179. doi: 10.1038/s41591-022-02112-7. Epub 2023 Jan 5.PMID: 3660453
Lee SHR, Ashcraft E, Yang W, Roberts KG, Gocho Y, Rowland L, Inaba H, Karol SE, Jeha S, Crews KR, Mullighan CG, Relling MV, Evans WE, Cheng C, Yang JJ, Pui CH. Prognostic and Pharmacotypic Heterogeneity of Hyperdiploidy in Childhood ALL. J Clin Oncol 2023 Dec 10;41(35):5422-5432. doi: 10.1200/JCO.23.00880. Epub 2023 Sep 20. PMID: 37729596; PMCID: PMC10852380.
Lee SHR, Antillon-Klussmann F, Pei D, Yang W, Roberts KG, Li Z, Devidas M, Yang W, Najera C, Lin HP, Tan AM, Ariffin H, Cheng C, Evans WE, Hunger SP, Jeha S, Mullighan CG, Loh ML, Yeoh AEJ, Pui CH, Yang JJ. Association of Genetic Ancestry With the Molecular Subtypes and Prognosis of Childhood Acute Lymphoblastic Leukemia. JAMA Oncol 2022 Mar 1;8(3):354-363. doi: 10.1001/jamaoncol.2021.6826.PMID: 35084434
Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet 2022 Sep;54(9):1376-1389. doi: 10.1038/s41588-022-01159-z. Epub 2022 Sep 1.PMID: 36050548
Jacola LM, Conklin HM, Krull KR, Pei D, Cheng C, Reddick WE, Pui CH, Jeha S.J The Impact of Intensified CNS-Directed Therapy on Neurocognitive Outcomes in Survivors of Childhood Acute Lymphoblastic Leukemia Treated Without Cranial Irradiation. Clin Oncol 2022 Dec 20;40(36):4218-4227. doi: 10.1200/JCO.22.00263. Epub 2022 Nov 2.PMID: 36322880
Zhang H, Liu AP, Devidas M, Lee SH, Cao X, Pei D, Borowitz M, Wood B, Gastier-Foster JM, Dai Y, Raetz E, Larsen E, Winick N, Bowman WP, Karol S, Yang W, Martin PL, Carroll WL, Pui CH, Mullighan CG, Evans WE, Cheng C, Hunger SP, Relling MV, Loh ML, Yang JJ. Association of GATA3 Polymorphisms With Minimal Residual Disease and Relapse Risk in Childhood Acute Lymphoblastic Leukemia. J Natl Cancer Inst 2021 Apr 6;113(4):408-417. doi: 10.1093/jnci/djaa138. PMID: 32894760.
Paietta E, Roberts KG, Wang V, Gu Z, Buck G, Pei D, Cheng C, Levine RL,Abdel-Wahab O, Cheng Z, Wu G, Qu C, Shi L, Pounds SB, Willman CL, Harvey RC,Racevskis J, Barinka J, Zhang Y, Dewald GW, Ketterling RP, Alejos D, Lazarus HM,Luger S, Foroni L, Patel B, Fielding AK, Melnick A, Marks DI, Moorman AV,Wiernik PH, Rowe JM, Tallman MS, Goldstone AH, Mullighan CG, Litzow MR. Molecular Classification Improves Risk Assessment in Adult BCR-ABL1-negative B-ALL. Blood 2021 Apr 25:blood.2020010144. doi: 10.1182/blood.2020010144. Epub ahead of print. PMID: 33895809.
Yang W, Cai J, Shen S, Gao J, Yu J, Hu S, Jiang H, Fang Y, Liang C, Ju X, Wu X, Zhai X, Tian X, Wang N, Liu A, Jiang H, Jin R, Sun L, Yang M, Leung AWK, Pan K, Zhang Y, Chen J, Zhu Y, Zhang H, Li C, Yang JJ, Cheng C*, Li CK, Tang J, Zhu X, Pui CH. Pulse therapy with vincristine and dexamethasone for childhood acute lymphoblastic leukaemia (CCCG-ALL-2015): an open-label, multicentre, randomised, phase 3, non-inferiority trial. Lancet Oncol 2021 Jul 27:S1470-2045(21)00328-4. doi: 10.1016/S1470-2045(21)00328-4. Online ahead of print. PMID: 34329606
Autry RJ, Paugh SW, Carter R, Shi L, Liu J, Ferguson DC, Lau CE, Bonten EJ, Yang W, McCorkle JR, Beard JA, Panetta JC, Diedrich JD, Crews KR, Pei D, Coke CJ, Natarajan S, Khatamian A, Karol SE Lopez-Lopez E, Diouf B, Smith C, Gocho Y, Hagiwara K, Roberts KG, Pounds S, Kornblau SM, Stock W, Paietta EM, Litzow MR, Inaba H, Mullighan CG, Jeha S, Pui CH, Cheng C, Savic D, Yu J, Gawad C, Relling MV, Yang JJ, Evans WE. Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia. Nat Cancer 2020 Mar;1(3):329-344. doi: 10.1038/s43018-020-0037-3. Epub 2020 Mar 9. PMID: 32885175; PMCID: PMC7467080.
Brady SW, Liu Y, Ma X, Gout AM, Hagiwara K, Zhou X, Wang J, Macias M, Chen X, Easton J, Mulder HL, Rusch M, Wang L, Nakitandwe J, Lei S, Davis EM, Naranjo A, Cheng C, Maris JM, Downing JR, Cheung NV, Hogarty MD, Dyer MA, Zhang J. Pan- neuroblastoma analysis reveals age- and signature-associated driver alterations. Nat Commun 2020 Oct 14;11(1):5183. doi: 10.1038/s41467-020-18987-4. PMID: 33056981; PMCID: PMC7560655.
Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet 51(2):296-307, Feb 2019
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG. Genomic subtyping and therapeutic targeting of acute erythroleukemia. Nat Genet 2019 Apr;51(4):694-704. doi: 10.1038/s41588-019-0375-1. Epub 2019 Mar 29.
Cheng, C. Exploratory failure time analysis in large scale genomics. Computational Statistics and Data Analysis, 95, 192-206, 2016. [doi: http://dx.doi.org/10.1016/j.csda.2015.10.004] NIHMS733642
Jacola LM, Krull KR, Pui CH, Pei D, Cheng C, Reddick WE, and Conklin HM, Longitudinal assessment of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia treated on a contemporary chemotherapy protocol. J Clin Oncol 34:1239-1247, 2016.
Liu CC, Yang WJ, Devidas M, Cheng C, Pei D, Smith C, Carroll WL, Raetz EA, Bowman WP, Larsen EC, Maloney KW, Martin PL, Mattano Jr. LA, Winick NJ, Mardis ER, Fulton, RS Bhojwani D, Howard SC, Jeha S, Pui CH, Hunger SP, Evans WE, Loh ML, Relling MV. Clinical and genetic risk factors for acute pancreatitis in patients with acute lymphoblastic leukemia. J Clin Oncol 34(18):2133-2140, 2016.
Yang JJ, Landier W, Yang W, Liu C, Hageman L, Cheng C, Pei D, Chen Y, Crews KR, Kornegay N, Wong FL, Evans WE, Pui CH, Bhatia S, Relling MV. Inherited NUDT15 Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia. J Clin Oncol 33:1235-1242, 2015. PMCID: PMC4375304
Diouf B, Crews KR, Lew G, Pei D, Cheng C, Bao J, Zheng J, Yang W, Fan Y, Wheeler HE, Wing C, Delaney S, Komatsu M, Paugh SW, McCorkle JR, Lu X, Winick NJ, Carroll WL, Loh ML, Hunger SP, Devidas M, Pui C-H, Dolan EM, Relling MV, and Evans WE. Association of an Inherited Genetic Variant with Vincristine-Related Peripheral Neuropathy in Children with Acute Lymphoblastic Leukemia. Journal of American Medical Association 313(8): 815-823, 2015.
Pui CH, Pei D, Coustan-Smith E, Jeha S, Cheng C, Bowman WP, Sandlund JT, Ribeiro RC, Rubnitz JE, Inaba H, Bhojwani D, Gruber TA, Leung WH, Downing JR, Evans WE, Relling MV, Campana D. Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study. Lancet Oncol 16:465-474, 2015.
Paugh SW, Bonten E, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RKS, Actis M, Mayasundari A, Min J, Cross DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karoll S, Fernandez CA, Diouf B, Smith C, J. Kevin Hicks, Alessandra Zanut, Audrey Giordanengo, Daniel Crona, Joy J. Bianchi, Linda Holmfeldt, Charles G. Mullighan, Monique L. den Boer, Rob Pieters, Sima Jeha, Thomas L. Dunwell, Farida Latif, Deepa Bhojwani, William L. Carroll, Ching-Hon Pui, R. Kiplin Guy, Thirumala-Devi Kanneganti, Mary V. Relling, and William E. Evans. NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells, Nature Genetics 47(6): 607-614, 2015.
Roberts KG, Pei D, Campana D, Payne-Turner D, Li Y, Cheng C, Sandlund JT, Jeha S, Easton J, Becksfort J, Zhang J, Coustan-Smith E, Raimondi SC, Leung WH, Relling MV, Evans WE, Downing JR, Mullighan, CG, Pui C-H. Outcomes of children with BCR-ABL1-like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease. Journal of Clinical Oncology 32(27): 3012-3020, 2014. PMCID: PMC4162497
Roberts K … Cheng C … Mullighan C. Targetable kinase activating lesions in Ph-like acute lymphoblastic leukemia, New England Journal of Medicine 371:1005-15, 2014. PMCID: PMC4191900.
Pounds S, Cheng C†, Li S, Zhang J, Mullighan C. Genomic random interval models for statistical analysis of genomic lesion data. Bioinformatics 29(17):2088-2095, 2013. [doi: 10.1093/bioinformatics/btt372. Epub 2013 Jul 10]
Krull KR; Bhojwani D; Conklin HM; Pei D; Cheng C; Reddick WE; Sandlund JT; Pui CH. Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia. J Clin Oncol 31(17):2182-2188, 2013.
Perez-Andreu V, Roberts KG, Harvey RC, Yang W, Cheng C, Pei D, Xu H, Gastier-Foster J, E S, Lim JY, Chen IM, Fan Y, Devidas M, Borowitz MJ, Smith C, Neale G, Burchard EG, Torgerson DG, Klussmann FA, Villagran CR, Winick NJ, Camitta BM, Raetz E, Wood B, Yue F, Carroll WL, Larsen E, Bowman WP, Loh ML, Dean M, Bhojwani D, Pui CH, Evans WE, Relling MV, Hunger SP, Willman CL, Mullighan CG, Yang JJ. Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet 45:1494-1498, 2013.
Cheng C. Integration of diverse statistical evidence of gene-trait association in systems biology studies. Chemistry and Biodiversity, 9(5):935-944, 2012; invited paper for Special Issue on Systems Biology: Molecular Networks and Disease. NIHMS414396
Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481:157-163, 2012.
Conklin HM; Krull KR; Reddick WE; Pei D; Cheng C; Pui CH. Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia. J Natl Cancer Inst 104(18):1386-1395, 2012
Yang JJ, Cheng C, Devidas M, Cao X, Campana D, Yang W, Fan Y, Neale G, Cox N, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Bowman WP, Camitta B, Reaman GH, Carroll WL, Willman CL, Hunger SP, Evans WE, Pui CH, Loh M, Relling MV. Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Blood 120:4197-4204, 2012.
Gao C, Cheng C.* A Phenotype-driven dimension reduction (PhDDR) approach to integrated genomic association analyses. Proceedings of 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp.6837-6840, 2011; invited paper for the special session on Informatics for Integrated Genomics. PMCID: PMC3652376
Nguyen P, Ma J, Pei D, Obert C, Cheng C, Geiger TL. Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire. BMC Genomics 12:106, 2011.
Yang J, Cheng C, Devidas M, Cao X, Fan Y, Campana D, Yang W, Neale G, Cox N, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Willman CL, Bowman WP, Camitta BM, Carroll A, Reaman GH, Carroll WL, Loh M, Hunger SP, Pui C-H, Evans WE, Relling MV. Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia, Nature Genetics 43:237-241, 2011.
Diouf B, Cheng Q, Krynetskaia NF, Yang W, Cheok M, Pei D, Fan Y, Cheng C, Krynetskiy EY, Chen S, Thierfelder WE, Mullighah CG, Downing JR, Hsieh P, Pui C-H, Relling MV, Evans, WE. Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nature Medicine 17:1298-1303, 2011.
Cheng C, Wu J. Interval estimation of quantile ratios applied to anti-cancer drug screening by xenograft experiments. Statistics in Medicine 29:2669-2678, 2010. PMCID: PMC3441185
Nguyen P, Liu W, Ma J, Manirarora J, Liu X, Cheng C, Geiger TL. Discrete TCR repertoires and CDR3 features distinguish effector and Foxp3+ regulatory T lymphocytes in myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis. J Immunol 185(7):3895-904, 2010. PMID: 20810983
Cheng C. Internal validation inferences of significant genomic features in genome-wide screening. Computational Statistics and Data Analysis 53:788-800, 2009. PMCID: PMC2805177
Pounds S, Cheng C†, Mullighan CG, Raimondi, SC, Shurtleff S, and Downing, JR. Reference alignment of SNP microarray signals for copy number analysis of tumors. Bioinformatics 25:315-321, 2009. PMCID: PMC2639073
Pounds S, Cheng C†, Cao X, Crews KR, Plunkett W, Gandhi V, Rubnitz J, Raul C. Ribeiro RC, Downing JR, Lamba J. PROMISE: A Tool to Identify Genomic Features with a Specific Biologically Interesting Pattern of Correlations with Multiple Endpoint Variables. Bioinformatics 25:2013-2019, 2009. PMCID: PMC2723006
Mullighan CG, Su X, Zhang J, Radtke I, Phillips LAA, Miller CB, Ma J, Liu W, Cheng C, Schulman BA, Harvey RC, Chen I-M, Clifford RJ, Carroll WL, Reaman G, Bowman PW, Devidas M, Gerhard DS, Yang W, Relling MV, Shurtleff SA, Campana D, Borowitz MJ, Pui C-H, Smith M, Hunger SP, Willman CL, Downing JR, and the Children's Oncology Group. Deletion of IKZF1 (IKSROS) is associated with poor prognosis in acute lymphoblastic leukemia, New England Journal of Medicine 360:470-480, 2009. PMCID: PMC2674612
Coustan-smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D, Cheng C, Su X, Rubnitz JE, Basso G, Biondi A, Pui C-H, Downing JR, Campana D. Early T-cell precursor leukemia: a subtype of very high-risk acute lymphoblastic leukemia identified in two independent cohorts. The Lancet Oncology 10:147-56, 2009. PMID: 19147408
Pui C-H, Campana D, Pei D, Bowman PW, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Coustan-Smith E, Kun LE, Jeha S, Cheng C, Howard SC, Simmons V, Bayles A, Metzger ML, Boyett JM, Leung W, Downing JR, Evans WE, Relling MV. Treatment of childhood acute lymphoblastic leukemia without prophylactic cranial irradiation. New England Journal of Medicine 360 (26):2730-2741, 2009. PMCID: PMC2754320
Flotho C, Coustan-Smith E, Pei D, Cheng C, Song G, Pui C-H, Downing JR, Campana D. A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia. Blood 110:1271-1277, 2007
Cheng C. An adaptive significance threshold criterion for massive multiple hypothesis testing. In Optimality: The Second Erich L. Lehmann Symposium, Institute of Mathematical Statistics, Beachwood, OH, USA; 49:51-76, 2006. http://projecteuclid.org/euclid.lnms/1196283955
Cheng Q, Cheng C, Crews KR, Ribeiro RC, Pui C-G, Relling MV, Evans WE. Epigenetic regulate of human g-glutamyl hydrolase activity in acute lymphoblastic leukemia cells. American Journal of Human Genetics 79:264-274, 2006.
Flotho C, Coustan-Smith E, Pei D, Iwamoto S, Song G, Cheng C, Pui C-H, Downing JR, Campana D. Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2. Blood 108:1050-1067, 2006.
Holleman A, Cheok MH, den Boer ML, Yang W, Veerman AJP, Kazemire KM, Pei D, Cheng C, Pui CH, Relling MV, Janka-Schaub GE, Pieters R, Evans WE. Gene expression patterns in drug- resistant acute lymphoblastic leukemia cells and response to treatment. New England J. Med 351(6):533-42, 2004.
Edick, MJ, Cheng C, Yang W, Cheok, M, Wilkinson MR, Pei D, Evans WE, Kun LE, Pui C-H, Relling, MV. Lymphoid Gene Expression as a predictor of risk of secondary brain tumors. Genes, Chromosomes & Cancer 42:107-16, 2005.
Marshall DR, Olivas E, Andreansky S, La Gruta NL, Neale GA, Gutierrez A, Wichlan DG, Wingo S, Cheng C, Doherty PC, Tuner SJ. Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression. Proc. Nat. Acad. Sci 102(17): 6074-9, 2005.
Lugthart S, Cheok MH, den Boer ML, Yang W, Holleman A, Cheng C, Pui C-H, Relling MV, Janka-Schaub GE, Pieters R, Evans WE Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia. Cancer Cell 7(4):375-386, 2005.
Li C-S and Cheng C†. Stable classification in the analysis of microarray data. Computational Statistics and Data Analysis, 47:599-609 2004.
Cheng C, Pounds S, Boyett JM, Pei D, Kuo M-L, Roussel MF. Statistical significance threshold criteria for analysis of microarray gene expression data. Statistical Applications in Genetics and Molecular Biology 3(1): Article 36, 2004.
Pui C-H, Cheng C, Rivera GK, Leung W, Sandlund JT, Riberio RC, Relling RV, Kun LE, Evans, WE, and Hudson MM. Extended follow up of long-term survivors of childhood acute lymphoblastic leukemia. New England Journal of Medicine 349:640-649, 2003.
Cheng C. Almost-sure uniform error bounds of general smooth estimators of quantile density functions. Statistics and probability Letters 59:183-194, 2002.
Yeoh E-J, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R., Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui C-H, Evans, WE, Naeve C, Wong L, and Downing JR. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1:133-143, 2002.
Cheng C and Tong YL. Concentration order on a metric space, with some statistical applications. Statistics and Probability Letters 44:327-335, 1999.
Cheng C. A Berry-Esseen type theorem of quantile density estimators. Statistics and Probability Letters 39:255-262, 1998.
Cheng C, Parzen E. Unified estimators of smooth quantile and quantile density functions. J Statistical Planning and Inference 59:291-307, 1997.
Cheng C, Maggiora GM, Lajiness MS, Johnson MA. Four association coefficients for relating molecular similarity measures. J Chem Inf Comput Sci 23:909-915, 1996.
Cheng C. Uniform consistency of generalized kernel estimators of quantile density. The Annals of Statistics 23:2285-2291, 1995.
† Corresponding author ‡ Contributed equally
Last update: April 2025