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Ti-Cheng Chang, PhD

Ti-Cheng Chang, PhD

  • Group Lead, Genomics

Education

PhD, Bioinformatics and Genomics - The Pennsylvania State University, State College, PA
MS
, Biochemistry and Molecular Biology - Georgetown University, DC
BS
, Zoology - National Taiwan University, Taipei, Taiwan

About

Ti-Cheng Chang is the Genomics Group Lead of the Center for Applied Bioinformatics at St. Jude Children's Research Hospital. His research is focused on developing computational genomics methods/workflows and applying them to understand disease etiology. 

Research Interests

  • Leverage genomic information to understand the emergence and evolution of diseases
  • Resolve complex genome rearrangement using multiple techniques including single-molecule long-read and short-read sequencing.
  • Develop algorithms to characterize and predict allele types in highly polymorphic genomic loci.
  • Metagenomics and immunogenomics. Investigate the association between the dynamics of metagenomics and clinical outcomes. Identify targetable epitopes for vaccine development.

Selected Publications

LeMessurier KS, Iverson AR, Chang TC, Palipane M, Vogel P, Rosch JW, Samarasinghe AE. Allergic inflammation alters the lung microbiome and hinders synergistic co-infection with H1N1 influenza virus and Streptococcus pneumoniae in C57BL/6 mice. Sci Rep. 2019 Dec 18;9(1):19360. doi: 10.1038/s41598-019-55712-8. PMID: 31852944

Wang Z, Rice SV, Chang TC, Liu Y, Liu Q, Qin N, Putnam DK, Shelton K, Lanctot JQ, Wilson CL, Ness KK, Rusch MC, Edmonson MN, Wu G, Easton J, Kesserwan CA, Downing JR, Chen X, Nichols KE, Yasui Y, Robison LL, Zhang J. Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers. J Natl Cancer Inst. 2019 Oct 24;. doi: 10.1093/jnci/djz210. PMID: 31647544.

Zamora AE, Crawford JC, Allen EK, Guo XJ, Bakke J, Carter RA, Abdelsamed HA, Moustaki A, Li Y, Chang TC, Awad W, Dallas MH, Mullighan CG, Downing JR, Geiger TL, Chen T, Green DR, Youngblood BA, Zhang J, Thomas PG. Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses. Sci Transl Med. 2019 Jun 26;11(498). doi: 10.1126/scitranslmed.aat8549. PMID: 31243155

Chang TC, Rosch JW, Gu Z, Hakim H, Hewitt C, Gaur A, Wu G, Hayden RT. Whole-Genome Characterization of Bacillus cereus Associated with Specific Disease Manifestations. Infect Immun. 2018 Feb;86(2). doi: 10.1128/IAI.00574-17. PMID: 29158433

Malik A, Sharma D, Malireddi RKS, Guy CS, Chang TC, Olsen SR, Neale G, Vogel P, Kanneganti TD. SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer. Immunity. 2018 Sep 18;49(3):515-530.e5. doi: 10.1016/j.immuni.2018.08.024. PMID: 30231985

Chang TC, Carter RA, Li Y, Li Y, Wang H, Edmonson MN, Chen X, Arnold P, Geiger TL, Wu G, Peng J, Dyer M, Downing JR, Green DR, Thomas PG, Zhang J. The neoepitope landscape in pediatric cancers. Genome Med. 2017 Aug 31;9(1):78. doi: 10.1186/s13073-017-0468-3. PMID: 28854978

Echlin H, Frank MW, Iverson A, Chang TC, Johnson MD, Rock CO, Rosch JW. Pyruvate Oxidase as a Critical Link between Metabolism and Capsule Biosynthesis in Streptococcus pneumoniae. PLoS Pathog. 2016 Oct;12(10):e1005951. doi: 10.1371/journal.ppat.1005951. PMID: 27760231

Chang TC, Salvucci A, Crous PW, Stergiopoulos I. Comparative Genomics of the Sigatoka Disease Complex on Banana Suggests a Link between Parallel Evolutionary Changes in Pseudocercospora fijiensis and Pseudocercospora eumusae and Increased Virulence on the Banana Host. PLoS Genet. 2016 Aug;12(8):e1005904. doi: 10.1371/journal.pgen.1005904. PMID: 27513322

Chang TC, Stergiopoulos I. Inter- and intra-domain horizontal gene transfer, gain-loss asymmetry and positive selection mark the evolutionary history of the CBM14 family. FEBS J. 2015 May;282(10):2014-28. doi: 10.1111/febs.13256. PMID: 25754577.

Chang TC, Yang Y, Retzel EF, Liu WS. Male-specific region of the bovine Y chromosome is gene rich with a high transcriptomic activity in testis development. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12373-8. doi: 10.1073/pnas.1221104110. Epub 2013 Jul 10. PMID: 23842086

Full List of Publications

Last update: June 2020