The Center for Applied Bioinformatics (CAB) was established in 2019 with a mission to provide centralized genomic and bioinformatic analytic services for investigators at St. Jude Children's Research Hospital. The CAB is composed of research scientists and software engineers of diverse background and expertise, covering the areas of genomics, genetics, transcriptomics and epigenetics.
The key responsibilities of the CAB include:
- Consult with St. Jude investigators on optimal experimental design for bioinformatics analyses
- Develop state-of-art, open-access computational pipelines to address the most needed bioinformatics analyses in the institution
- Provide standard and customized bioinformatics analyses to St. Jude investigators
- Train students, postdoctoral fellows and staff scientists in standard bioinformatics analyses using pipelines deployed either in-house or by public web applications and software
- Maintain the common reference annotation and datasets shared across the institution
The CAB strives to deliver high-quality results in a timely manner and emphasizes applied and expedient genetic and bioinformatics analyses for St. Jude research laboratories. It advocates a culture of open science and promotes a highly collaborative environment for joint computational tool development across various computational groups within the institution to support the mission of St. Jude and the research efforts of St. Jude investigators.
Gang Wu, PhD, is director of the Center for Applied Bioinformatics and assistant member of the St. Jude Faculty.
Employee Spotlight: Corey Xu
As a bioinformatics research scientist, Corey Xu, Ph.D., focuses on brain tumor genomics powered by next-generation sequencing technologies. “I chose to come to St. Jude because I was inspired by the mission it stands for, and I was really impressed by the research capacity when I was interviewing here.” He works on several projects in the CAB, including working with clinicians at St. Jude to characterize the genomic landscape and mutational signatures of radiation therapy-induced high-grade gliomas.