Skip to main content
Melissa Hines, MD
Melissa Hines, MD

Melissa Hines, MD

Associate Member, St. Jude Faculty

  • Director, Histiocytosis and Immune Dysregulation Team




Fellow (Pediatric Critical Care Medicine) - North Carolina Children’s Hospital, University of North Carolina Hospitals, Chapel Hill, NC
(General Pediatrics) - Le Bonheur Children’s Hospital, St Jude Children’s Research Hospital, University of Tennessee Health Science Center, Memphis, TN
- University of Tennessee Health Science Center, Memphis, TN
- Christian Brothers University, Memphis, TN

Honors & Awards

  • 2016  Amal Murarka Pediatric Teaching Award, University of North Carolina, Department of Pediatrics
  • 2010  Faculty Medal for Highest Academic Achievement, University of Tennessee, award given to medical school graduate with highest grade point average
  • 2009  Albright Armstrong Rice Scholarship, University of Tennessee, scholarship awarded based on academic merit
  • 2009  American Medical Association Scholars Fund, University of Tennessee, scholarship awarded based on academic merit
  • 2006 to 2008  Alumni Merit Scholarship, University of Tennessee, scholarship awarded based on academic merit

Research Interests

  • Hemophagocytic Lymphohistiocytosis (HLH)
  • Use of new therapies for HLH
  • Immune system dysregulation in pediatric hematology/oncology patients during critical illness including
    • Hyperinflammation
    • Thrombotic microangiopathy (TMA)
  • Use of cytokine inhibition and biologic therapies in pediatric critical illness
  • Immune-effector cell associated hemophagocytic syndrome (IEC-HS) and immune-effector cell associated cytokine release syndrome (CRS)

Selected Publications

Hines M,* Keenan C, Maron Alfarao G, Chen, C, Zhou Y, Akshay S, Hurley C, Nichols K, Gottschalk S, Triplett B, Talleur A. Hemophagocytic Lymphohistiocytosis-like Toxicity after CD19-specific CAR T-cell Therapy. British Journal of Haematology Aug;194(4):701-707, 2021.

Blincoe A, Heeg M, Campbell P, Hines M, Khojah A, Klein-Gitelman M, Talano JA, MDj, Speckmann C, Touzot F, Lankester A, Legger GE, Rivière JG, Garcia-Prat M, Alonso L, Putti MC, Lehmberg K , Maier S, El Chazli Y, Abd Elmaksoud, Astigarraga I, Kurjane N, Bulina I, Kenina V, Bryceson Y, Rascon J, Lortie A, Goldstein G, Booth C, Worth A, Wassmere E, Schmitt EG, Warren JT, Bednarski JJ, Ali S, Chiang KY, Krueger J, Henry MM, Holland SM, Marsh R, Ehl S, Haddad E. Neuroinflammatory disease as an isolated manifestation of Hemophagocytic Lymphohistiocytosis. Journal of Clinical Immunology Jul 7, 2020. doi: 10.1007/s10875-020-00814-6. [Epub ahead of print] PubMed PMID: 32638196

Chellapandian D, Hines MR*, Zhang R, Jeng M, van den Bos C, Santa-Maria Lopez V, Lehmberg K, Sieni E, Wang Y, Nakano T, Williams JA, Fustino NJ, Astigarraga I, Dunkal IJ, Abla O, van Halteren AGS, Pei, D, Cheng C, Weitzman S, Sung L, Nichols KE. A multi-center study of patients with multisystem Langerhans cell histiocytosis who develop secondary hemophagocytic lymphohistiocytosis. Cancer 125(6):963-971, 2019. PMID: 30521100

Hines MR, Mulrooney DA, Hudson MM, Ness KK, Grenn, DM, Howard SC, Krasin M, Metzger ML. Pregnancy-associated cardiomyopathy in survivors of childhood cancer. Journal of Cancer Survivorship: Research and Practice Feb;10(1):113-21, 2016.

Hines-Thomas MR, Howard SC, Hudson MM, Krasin MJ, Kaste SC, Shulkin BL, Metzger ML. Utility of bone marrow biopsy at diagnosis in pediatric Hodgkin's lymphoma. Haematologica Oct;95(10):1691-6, 2010.  

Zhao Y, Xiao J, Ueda M, Wang Y, Hines M, Nowak TS, LeDoux MS. Glial elements contribute to stress-induced torsinA expression in the CNS and peripheral nervous system. Neuroscience 155 (2):439-53, 2008.

Hines-Thomas M, Kaste SC, Hudson MM, Howard SC, Liu WA, Wu J, Kun LE, Shulkin BL, Krasin MJ, Metzger ML. Comparison of PET and gallium scans at diagnosis and follow-up in pediatric patients with Hodgkin’s lymphoma. Pediatric Blood and Cancer 51(2):198-203 2008.

Last update: August 2023