Randall T. Hayden, MD
Randall T. Hayden, MD

Randall T. Hayden, MD

Member, St. Jude Faculty

  • Director, Clinical and Molecular Microbiology
  • Medical Director, Clinical Pathology
  • Director, Global Pathology and Laboratory Medicine



MD – University of Illinois College of Medicine (1989)

Research Interests

  • Application of molecular diagnostic techniques to clinical microbiology
  • Diagnostic microbiology of the Immunocompromised Pediatric Host
  • Morphologic diagnosis of infectious diseases in tissue
  • Laboratory diagosis of infectious diseases in resource-limited settings

Testing of infectious pathogens in patient samples

Selected Publications

Massire C, Buelow DR, Zhang SX, Lovari R, Matthews HE,. Toleno DM, Ranken RR,. Hall TA, Metzgar D, Sampath R, Blyn LB, Ecker DJ, Gu Z, Walsh TJ, Hayden RT. PCR Followed by Electrospray Ionization Mass Spectrometry for Broad Range Identification of Fungal Pathogens. J Clin Micro Jan 9, 2013.

Hayden RT, Gu Z, Ingersoll J, Abdul-Ali D, Shi L, Pounds S, Caliendo AM. Comparison of Droplet Digital PCR to Real-Time PCR for Quantitative Detection of Cytomegalovirus. J Clin MicroFeb;51(2):540-62013, 2013.

Srinivasan A, Wang C, Srivastava DK, Burnette K, Shenep JL, Leung W, Hayden RT. Timeline, epidemiology and risk factors for bacterial, fungal and viral infections in children and adolescents after allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation Jan;19(1):94-101, 2013.

Srinivasan A, Flynn P, Gu Z, Hartford C, Lovins R, Sunkara A, Srivastava DK, Leung W, Hayden RT. Detection of Respiratory Viruses in Asymptomatic Children Undergoing Allogeneic Hematopoietic Cell Transplantation. Pediatric Blood & Cancer Jan;60(1):149-51, 2013.

Buelow DR, Gu Z, Walsh TJ, Hayden RT. Evaluation of Multiplexed PCR and Liquid-phase Array for Identification of Respiratory Fungal Pathogens. Medical Mycology Oct;50(7):775-80, 2012.

Hayden RT, Gu Z, Rodriguez A, Tanioka L, Ying C, Morgenstern M, Bankowski MJ. Comparison of Two Broadly Multiplexed PCR Systems for Viral Detection in Clinical Respiratory Tract Specimens from Immunocompromised Children. J Clin Virol  Apr;53(4):308-13, 2012.

Hayden RT, Yan X, Wick MT, Rodriguez AB, Xiong X, Ginocchio CC, Mitchell MJ, Caliendo AM, CN - for the College of American Pathologists Microbiology Resource Committee. Factors contributing to variability of quantitative viral PCR results in proficiency testing samples: a multivariate analysis. J Clin Microbiol November 23, 2011.

Gu Z, Hall TA, Frinder M, Walsh TJ, Hayden RT. Evaluation of repetitive sequence PCR and PCR-mass spectrometry for the identification of clinically relevant Candida species. Med Mycol August 23, 2011.

Hayden, Carroll, Tang, Wolk. Diagnostic Microbiology of the Immunocompromised Host. ASM Press, (Editor-in-Chief), 2009.

Gu Z, Pan J, Bankowski MJ, Hayden RT. Quantitative Real-time PCR Detection of BK Virus (BKV) Using Labeled Primers. Arch Path Lab Med 2009.

Vincent E, Gu Z, Morgenstern M, Gibson C, Pan J, Hayden RT. Detection of Cytomegalovirus in Whole Blood Using Three Different Real-Time PCR Chemistries Journal of Molecular Diagnostics11(1):54-59, 2009.

Hayden R, Pounds S, Petraitiene R, Schaufele R, Sein T, Walsh. Galactomannan Antigenemia in Pediatric Oncology Patients with Invasive Aspergillosis. PIDJ 27(9):815-19, 2008.

Adderson EA, Boudreaux JW, Cummings JR, Pounds SB, Hayden RT. Identification of Clinical Coryneform Bacterial Isolates: A Comparison of Biochemical Methods and Sequence Analysis of 16S rRNA and rpoB. JCM 46(3):921-7, 2008.

Hayden RT, Hokanson KM, Pounds SB, Bankowski MJ, Belzer SW, Carr J, Diorio D, Forman MS, Joshi Y, Hillyard D, Hodinka RL , Nikiforova MN, Romain CA, J Stevenson, A Valsamakis, HH Balfour HH. A Multicenter Comparison of Different Real-Time PCR Assays for the Quantitative Detection of Epstein Barr Virus (EBV). JCM 46(1):157-63, 2008.

Hayden RT, Patterson DJ, Jay DW, Cross C, Dotson P, Possel RE, Srivastava DK, Mirro J, Shenep JL. Computer-Assisted Bar-Coding System Significantly Reduces Clinical Laboratory Specimen Identification Errors. J Ped 152(2):219-24, 2008.

Perlman J, Gibson C, Pounds SB, Gu Z, Bankowski MJ, Hayden RT. Quantitative Real-time PCR Detection of Adenovirus in Clinical Blood Specimens: A Comparison of Plasma, Whole Blood and Peripheral Blood Mononuclear Cells. J Clin Virol 40(4):295-300, 2007.

Hakim H, Gibson C, Pan J, Srivastava K, Gu Z, Bankowski MJ, Hayden RT. Comparison of Various Blood Compartments and Reporting Units for the Detection and Quantification of Epstein-Barr Virus (EBV) in Peripheral Blood. JCM 45(7):2151-5, 2007.

Cummings J, Jamison G, Boudreaux J, Howles M, Walsh T, Hayden R. Cross-Reactivity of Non-Aspergillus Fungal Species in the Aspergillus Galactomannan Enzyme Immunoassay. Diagn Microbiol Infect Dis 59: 113–115, 2007.

El Saleeby CM, Jamison GR, Pounds SB, Hewitt CB, Hayden RT. Filtration-based Culture Methods Improve Recovery of Fungal Pathogens in Respiratory Specimens. Diagn Microbiol Infect Dis 56: 221-223, 2006.

Yusuf U, Hale G, Woodward P, Benaim E, Kasow K, Horwitz E, Leung W, Srivastava DK, Handgretinger R, Hayden R. Cidofovir is Safe and Effective in the Treatment of Adenoviral Infection in Pediatric Hematopoetic Stem Cell Transplantation. Transplantation 81(10):1398-1404, 2006.

El Saleeby CM, Allison K, Knapp K, Walsh T, Hayden RT. Discordant Rise in Galactomannan Antigenemia in a Patient with Resolving Aspergillosis, Renal Failure, and Ongoing Hemodialysis. J Clin Microbiol 43(7): 3560-3563, 2005.

Gaur AH, Flynn PM, Heine DJ, Giannini MA, Shenep JL, Hayden RT. Diagnosis of catheter related bloodstream infection in immunocompromised pediatric patients in the absence of peripheral cultures. Pediatr Infect Dis J 24(5):445-449, 2005.

Gu Z, Belzer SW, Gibson CS, Bankowski MJ, Hayden RT. Multiplexed, real-time PCR for quantitative detection of human adenovirus. J Clin Microbiol 41(10):4636-4621, 2003.

Gaur AH, Giannini MA, Flynn PM, Boudreaux JW, Mestemacher MA, Shenep JL, Hayden RT. Optimizing blood culture practices in pediatric immunocompromised patients: evaluation of media types and blood culture volume. Pediatr Infect Dis J 22(6):545-521, 2003

Gaur, AH, Flynn PM, Giannini MA, Shenep JL, Hayden RT. Differential time to positivity (DTP): A simple method for the diagnosis of catheter-related infection (CRI) in immunocompromised pediatric patients. Clin Infect Dis 37(4):469-475, 2003.

Hayden RT, Isotalo PA, Parrett T, Qian X, Roberts GD, Lloyd RV. In Situ Hybridization for the Differentiation of Aspergillus, Fusarium and Pseudoallescheria Species in Tissue Section. Diag Mol Pathol 12(1):21-26, 2003.

Hayden R, Qian X, Procop G, Roberts G, Lloyd R. In situ DNA hybridization for the identification of filamentous fungi in tissue section. Diagn Mol Pathol 11(2):119-126, 2002.

Hayden R, Persing DH. Molecular methods for diagnostic microbiology: current and future trends.Current Topics in Clinical Infectious Disease 21:323-348, 2001.

Hayden R, Kolbert C, Persing DH. Identification of spiral-form bacteria by 16S rDNA sequence analysis. Diagn Microbiol Infect Dis 39(1):55-59, 2001.

Hayden R, Roberts G, Lloyd R. In-Situ Hybridization for the Identification of Yeast-Like Organisms in Tissue Section. Diagn Mol Pathol 10(1): 15-23, 2001.


Last update: February 2013