John T. Lucas, Jr., MS, MD
John T. Lucas Jr., MS, MD

John T. Lucas Jr., MS, MD

Assistant Member, St. Jude Faculty



BS – Erskine College, Due West, South Carolina
MD – Medical University of South Carolina, Charleston
MS – Medical University of South Carolina, Charleston
Medicine Internship – University of North Carolina, Chapel Hill, NC
Residency (Radiation Oncology) – Wake Forest Baptist Medical Center, Winston-Salem, NC

Honors & Awards

  • 2015 ASCO/AACR Vail Course Methods in Clinical Cancer Research Scholar
  • 2007 Scholar-in-Training Award, American Association for Cancer Research
  • 2007 Edith Peng Excellence in Cancer Research Endowment Award
  • 2003 William L. Ellison Memorial Award  
  • 2002 E.L. Reid Award in Chemistry

Research Interests

  • Diffusion/perfusion MRI as a measure of radiation change and disease status
  • Neuroblastoma
  • High grade glioma
  • Proteomics
  • Clinical trial design/methodology

Selected Publications

Dunn CL, Lucas JT Jr, Clark H, McLean TW. Successful Radiofrequency Ablation for Recurrent Pulmonary Hepatoblastoma.  Pediatric Blood and Cancer June 24, 2015, DOI: 10.1002/pbc.25617. PMID: 26109368.

Johnson AG, Ruiz J, Hughes R, Page BR, Isom S, Lucas JT Jr, McTyre EM, Houseknecht KW, Ayala-Peacock DN, Bourland JD, Hinson WH, Laxton AW, Tatter SB, Debinski W, Watabe K, Chan MD. Impact of Systemic Targeted Agents on the Clinical Outcomes of Patients with Brain Metastases. Oncotarget June 2015. PMID: 26087184.

Lucas JT Jr, Colmer HG IV, White L, Isom S, Ellis TL, Urbanic JJ, Tatter SB, Chan MD. A Competing Risk Analysis of Neurologic vs Non-Neurologic Death in Patients Undergoing Radiosurgical Salvage Following Whole Brain Radiotherapy Failure (WBRT): Who Actually Dies of Their Brain Metastases? International Journal of Radiation Oncology Biology and Physics April 2015. 10.1016/j.ijrobp.2015.04.032. PMID: 26050609.

Lucas JT Jr, Huang A, Tatter SB, Chan MD. Anaplastic Ganglioglioma: A Report of Three Cases and Review of the Literature. Journal of Neuro-Oncology April 2015. PMID: 25862009

Lucas JT Jr, Ladra M, MacDonald SM, Friedmann A, Busse P, Tarbell NJ, Yock T. Pediatric Esthesioneuroblastoma: A Case Series. Pediatric Blood and Cancer Mar 27, 2015. doi: 10.1002/pbc.25494. PMID: 25820437

Mu F, Lucas JT Jr, Watts JM, Johnson AJ, Bourland JD, Laxton AW, Chan MD, Tatter SB. Tumor Resection with Carmustine Wafer Placement as Salvage Therapy after Local Failure of Radiosurgery for Brain Metastasis: Outcomes and Imaging. Journal of Clinical Neuroscience Jan 2, 2015. PMID: 25560387

Liu A, Kuhn EN, Lucas JT Jr, Laxton AW, Tatter SB, Chan MD. Gamma Knife Radiosurgery for Meningiomas in Neurofibromatosis Type 2 Patients. Journal of Neurosurgery Jan;2:1-7, 2015. PMID: 25555193

Neal MT, Chan MD, Lucas JT Jr, Loganathan A, Dillingham C, Pan E, Stewart JH, Bourland JD, Shaw EG, Tatter SB, Ellis TL. Predictors of Neurologic Death in Patients with Metastatic Melanoma Brain Metastases. World Neurosurg Dec;82(6):1250-5, 2014. PMID: 23402867

Huang AJ, Huang KE, Ayala-Peacock DN, Page BR, Lucas JT Jr, Lesser GJ, Laxton AW, Tatter SB, Chan MD. Risk Factors for Leptomeningeal Carcinomatosis in Patients with Brain Metastases who have Previously Undergone Stereotactic Radiosurgery. Journal of NeuroOncology July 2014. PMID: 25048529

Ayala-Peacock D, Peiffer A, Lucas JT Jr, Isom S, Kuremsky JG, Urbanic JJ, Bourland JD, Laxton AW, Tatter SB, Shaw EG, Chan MD. A nomogram for predicting distant brain failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy. Neuro Oncol Feb 20, 2014. PMID: 24558022

Jenkins RW, Clarke CJ, Lucas JT Jr, Shabbir M, Wu B, Simbari F, Mueller J, Hannun YA, Lazarchick J, Shirai K. Evaluation of the Role of Secretory Sphingomyelinase and Bioactive Sphingolipids as Biomarkers in Hemophagocytic Lymphohistiocytosis. American Journal of Hematology July 2013. PMID: 23828274

Lester S, Taksler GB, Kuremsky JG, Lucas JT Jr, Ayala-Peacock DA, Randolph II DM, Bourland JD, Laxton AW, Tatter SB, Chan MD. Clinical and Economic Outcomes of Patients with Brain Metastases Based on Symptoms:  An Argument for Routine Brain Screening of Those Treated with Upfront Radiosurgery. Cancer June 2013. PMID: 24452675.

Zauls AJ, Watkins JM, Lucas JT Jr, Shirai K, Sharma AK. Requirement of percutaneous endoscopic gastric tube placement in head-and-neck cancer treated with definitive concurrent chemoradiotherapy: an analysis of clinical and anatomic factors. Pract Radiat Oncol 3:e61-369, 2013. PMID: 24674322.    

Shabbir M, Lucas JT Jr, Buckner CL, Lazarchick J, Shirai K. Secondary hemophagocytic syndrome in adults: a case series of 18 patients in a single institution and a review of literature. Hematol Oncol Aug 30, 2010. PMID: 20809477. 

Lucas JT Jr, Salimath BG, Slomiany MG, Schey KL, Rosenzweig SA. Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent. Oncogene Aug;29: 4449-4459, 2010. PMID: 20498643

Williams VC, Lucas JT Jr, Gutmann DH, Korf B, Maria BL. Neurofibromatosis Type 1 Revisited. Pediatrics Jan;123:124-133, 2009. PMID: 19117870

Maria BL, Gupta N, Gilg AG, Abdel-Wahab M, Leonard AP, Slomiany M, Wheeler WG, Tolliver LB, Babcock MA, Lucas JT Jr, Toole BP. Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas. J Child Neurol Oct;23(10):1214-20, 2008. PubMed  PMID: 18952588.

Last update: October 2015