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John T. Lucas, Jr., MS, MD
John T. Lucas Jr., MS, MD

John T. Lucas Jr., MS, MD

Associate Member, St. Jude Faculty



BS – Erskine College, Due West, South Carolina
MD – Medical University of South Carolina, Charleston
MS – Medical University of South Carolina, Charleston
Medicine Internship – University of North Carolina, Chapel Hill, NC
Residency (Radiation Oncology) – Wake Forest Baptist Medical Center, Winston-Salem, NC

Honors & Awards

  • 2015 ASCO/AACR Vail Course Methods in Clinical Cancer Research Scholar
  • 2007 Scholar-in-Training Award, American Association for Cancer Research
  • 2007 Edith Peng Excellence in Cancer Research Endowment Award
  • 2003 William L. Ellison Memorial Award  
  • 2002 E.L. Reid Award in Chemistry

Research Interests

  • Diffusion/perfusion MRI as a measure of radiation change and disease status
  • Neuroblastoma
  • High grade glioma
  • Proteomics
  • Clinical trial design/methodology

Selected Publications

Lucas JT, McGee R, Billups CA, Qaddoumi I, Merchant TE, Brennan RC, Wu J, Wilson MW. Prior non-irradiative focal therapies do not compromise the efficacy of delayed episcleral plaque brachytherapy in retinoblastoma. Br J Ophthalmol June 28, 2019. PMID: 29954786

Lucas JT Jr, Pappo AS. Optimal dosing of cyclophosphamide in rhabdomyosarcoma: It's complicated. Cancer June 7, 2019. PMID: 31174230

Stiles ZE, Murphy AJ, Anghelescu DL, Brown CL, Davidoff AM, Dickson PV, Glazer ES, Bishop MW, Furman WL, Pappo AS, Lucas JT Jr, Deneve JL. Desmoplastic small round cell tumor: Long-term complications after cytoreduction and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol April 8, 2019. PMID: 30963398

Lucas JT Jr, McCarville MB, Cooper DA, Doubrovin M, Wakefield D, Santiago T, Li Y, Li X, Krasin M, Santana V, Furman W, Davidoff AM. Implications of image-defined risk factors and primary site response on local control and radiation treatment delivery in the management of high risk neuroblastoma: Is there a role for de-escalation of adjuvant primary site radiotherapy? Int J Radiat Oncol Biol Phys  103(4):869-877, 2019. PMID: 30496881

Hsu CY, Li Y, Han Y, Elijovich L, Sabin ND, Abuelem T, Torabi R, Faught A, Hua CH, Klimo P, Merchant T, Lucas JT Jr. Automatic image processing pipeline for tracking longitudinal vessel changes in magnetic resonance angiography. J Magn Reson Imaging March 7, 2019. PMID: 30843642

Wakefield DV, Eaton BR, Dove APH, Hsu CY, Merchant TE, Pappo A, Davidoff AM, Esiashvili N, Krasin MJ, Lucas JT Jr. Is there a role for salvage re-irradiation in pediatric patients with locoregional recurrent rhabdomyosarcoma? Clinical outcomes from a multi-institutional cohort. Radiother Oncol 129(3):513-519, 2018. PMID: 30017104

Dove AP, Manole BA, Wakefield DV, Cross SJ, Doubrovin M, Shulkin BL, Merchant TE, Davidoff AM, Furman WL, Krasin MJ, Santana VM, Lucas JT Jr. Managing local-regional failure in children with high-risk neuroblastoma: A single institution experience. Pediatr Blood Cancer 65(12):e27408, 2018. PMID: 30270551

Lucas JT Jr, Pappo AS, Wu J, Indelicato DJ, Krasin MJ. Excessive treatment failures in patients with parameningeal rhabdomyosarcoma with reduced-dose cyclophosphamide and delayed radiotherapy. J Pediatr Hematol Oncol 40(5):387-390, 2018. PMID: 29683960

Dixon SB, Bjornard KL, Alberts NM, Armstrong GT, Brinkman TM, Chemaitilly W, Ehrhardt MJ, Fernandez-Pineda I, Force LM, Gibson TM, Green DM, Howell CR, Kaste SC, Kirchhoff AC, Klosky JL, Krull KR, Lucas JT Jr, Mulrooney DA, Ness KK, Wilson CL, Yasui Y, Robison LL, Hudson MM. Factors influencing risk-based care of the childhood cancer survivor in the 21st century. CA Cancer J Clin 68(2):133-152, 2018. PMID: 29377070

Lucas JT Jr, Fernandez-Pineda I, Tinkle CL, Bishop MW, Kaste SC, Heda R, Davidoff AM, Krasin MJ. Late toxicity and outcomes following radiation therapy for chest wall sarcomas in pediatric patients. Pract Radiat Oncol 7(6):411-417, 2017. PMID: 28676226

Lucas JT Jr, Cooper DA, Hwang S, Tinkle C, Li X, Li Y, Orr B, Merchant TE, Broniscer A. Prognostic relevance of treatment failure patterns in pediatric high-grade glioma: Is there a role for a revised failure classification system? Int J Radiat Oncol Biol Phys 99(2):450-458, 2017. PMID: 28871996

Dunn CL, Lucas JT Jr, Clark H, McLean TW. Successful Radiofrequency Ablation for Recurrent Pulmonary Hepatoblastoma.  Pediatric Blood and Cancer June 24, 2015, DOI: 10.1002/pbc.25617. PMID: 26109368.

Lucas JT Jr, Huang A, Tatter SB, Chan MD. Anaplastic Ganglioglioma: A Report of Three Cases and Review of the Literature. Journal of Neuro-Oncology April 2015. PMID: 25862009

Lucas JT Jr, Ladra M, MacDonald SM, Friedmann A, Busse P, Tarbell NJ, Yock T. Pediatric Esthesioneuroblastoma: A Case Series. Pediatric Blood and Cancer Mar 27, 2015. doi: 10.1002/pbc.25494. PMID: 25820437

Liu A, Kuhn EN, Lucas JT Jr, Laxton AW, Tatter SB, Chan MD. Gamma Knife Radiosurgery for Meningiomas in Neurofibromatosis Type 2 Patients. Journal of Neurosurgery Jan;2:1-7, 2015. PMID: 25555193

Jenkins RW, Clarke CJ, Lucas JT Jr, Shabbir M, Wu B, Simbari F, Mueller J, Hannun YA, Lazarchick J, Shirai K. Evaluation of the Role of Secretory Sphingomyelinase and Bioactive Sphingolipids as Biomarkers in Hemophagocytic Lymphohistiocytosis. American Journal of Hematology July 2013. PMID: 23828274 

Shabbir M, Lucas JT Jr, Buckner CL, Lazarchick J, Shirai K. Secondary hemophagocytic syndrome in adults: a case series of 18 patients in a single institution and a review of literature. Hematol Oncol Aug 30, 2010. PMID: 20809477. 

Lucas JT Jr, Salimath BG, Slomiany MG, Schey KL, Rosenzweig SA. Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent. Oncogene Aug;29: 4449-4459, 2010. PMID: 20498643

Williams VC, Lucas JT Jr, Gutmann DH, Korf B, Maria BL. Neurofibromatosis Type 1 Revisited. Pediatrics Jan;123:124-133, 2009. PMID: 19117870

Maria BL, Gupta N, Gilg AG, Abdel-Wahab M, Leonard AP, Slomiany M, Wheeler WG, Tolliver LB, Babcock MA, Lucas JT Jr, Toole BP. Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas. J Child Neurol Oct;23(10):1214-20, 2008. PubMed  PMID: 18952588.

Last update: July 2019