Arzu Onar-Thomas, PhD
Arzu Onar-Thomas, PhD

Arzu Onar-Thomas, PhD

Member, St. Jude Faculty



BS (Mathematical Sciences) – University of North Carolina, Chapel Hill, NC (1993)
MS (Statistics) – University of South Carolina, Columbia, SC (1995)
PhD (Statistics) – University of South Carolina, Columbia, SC (1998)

Research Interests

  • Early phase clinical trial designs
  • Survival analysis
  • Accelerated testing and degradation models

Selected Publications

Su J, Li XN, Adekunle A, Kocak M, Onar-Thomas A, Blaney S, Fouladi M, Boyett JM, Kun LE. A Phase I Clinical Trial of ABT-888 (Veliparib) and Temozolomide in Children with Recurrent Central Nervous System Tumors: A Pediatric Brain Tumor Consortium Report. Neuro-Oncology doi: 10.1093/neuonc/nou103. First published online: June 7, 2014.

Wu G, Diaz A, Paugh B, Rankin S, Ju B, Li Y, Zhu X, Qu C, Chen X, Easton J, Edmonson M, Ma X, Lu C, Nagahawatte P, Hedlund E, Rusch M, Pounds S, Lin T, Onar-Thomas A, Huether R, Kriwacki R, Parker M, Gupta P, Becksfort J, Mulder HL, Boggs K, Vadodaria B, Yergeau D, Jake R, Kerry O, Chris J, Boop F, Broniscer A, Wetmore C, Gajjar A, Li D, Elaine MS, Rick W, Taylor Ml, Downing J, Ellison D, Zhang J, Lei W, Robert F, Lucinda F. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nature Genetics 46(5):444-50, 2014. PMID: 24705251

Dorris K, Sobo M, Onar-Thomas A, Panditharatna E, Stevenson CB, Gardner SL, DeWire MD, Pierson CR, Rempel SA, Olshefski R, Goldman S, Miles L, Fouladi M, Drissi R. Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas. Neuro-Oncology 117(1):67-76, 2014. PMID: 24477622.

Palmer SL, Leigh L, Onar-Thomas A, Wu S, Qaddoumi I, Armstrong GT, Wright K, Wetmore C, Broniscer A, Gajjar A. Feasibility of a computer-based intervention aimed at preventing reading decoding deficits among children undergoing active treatment for medulloblastoma: results of a randomized trial. Journal of Pediatric Psychology 39(4):450-8, 2014. PMID: 24369366.

Gurney J, Bass J, Onar-Thomas A, Huang J, Chintagumpala M, Bouffet E, Hassall T, Gururangan S, Heath JA, Kellie S, Cohn R, Fisher MJ, Armstrong GT, Panandiker ATP, Merchant TE, Srinivasan A, Wetmore C, Qaddoumi I, Broniscer A, Stewart CF, Gajjar A. Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average risk or high risk medulloblastoma. Neuro-Oncology Jan 16, 2014. Epub ahead of print. PMID: 24414535.

Bass J, Huang J, Onar-Thomas A, Chang K, Bhagat SP, Gajjar A, Gurney J. Concordance between the Chang and the International Society of Pediatric Oncology Boston ototoxicity grading scales.Pediatric Blood and Cancer 61(4):601-5, 2014. PMID 24504791.

Shan ZY, Leiker AJ, Onar-Thomas A, Li Y, Reddick WE, Shulkin BL. Regional Age-Dependent Changes in Cerebral Glucose Metabolism on Positron Emission Tomography of Children. Human Brain Mapping 35(5):2297-309, 2014. PMID: 23897639.

Gururangan S, Fangusaro J, Poussaint TY, McLendon RE, Onar-Thomas A, Wu S, Packer RJ, Banerjee A, Gilbertson RJ, Fahey F, Vajapeyam S, Jakacki R, Gajjar A, Goldman S, Pollack I, Friedman HS, Boyett JM, Fouladi M, Kun LE. Efficacy of bevacizumab plus irinotecan in children with recurrent low grade gliomas – a Pediatric Brain Tumor Consortium Study. Neuro-Oncology 16(2):310-7, 2014. PMID: 24311632.

Paugh BS, Zhu X, Qu C, Endersby R, Diaz AK, Zhang J, Bax DA, Carvalho D, Reis RM, Onar-Thomas A, Broniscer A, Wetmore C, Zhang J, Jones C, Ellison DW, Baker SJ. Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas. Cancer Research Oct 15;73(20):6219-29, 2013. PMID: 23970477.

Fangusaro J, Gururangan S, Poussaint TY, McLendon RE, Onar-Thomas A, Warren KE, Wu S, Packer RJ, Banerjee A, Gilbertson RJ, Jakacki R, Gajjar A, Goldman S, Pollack I, Friedman HS, Boyett JM, Kun LE, Fouladi M. Bevacizumab (BVZ)-Associated Toxicities in Children with Recurrent Central Nervous System (CNS) Tumors treated with BVZ and Irinotecan (CPT-11): a Pediatric Brain Tumor Consortium Study-022 (PBTC-022). Cancer 119(23):4180-7, 2013. PMID: 24104527.

Jackson S, Patay Z, Howarth R, Panandiker ASP, Onar-Thomas A, Gajjar A and Broniscer A. Clinico-radiologic characteristics and neurocognitive assessment of long-term survivors of diffuse intrinsic pontine glioma. Journal of Neuro-Oncology 114(3):339-44, 2013. PMID: 23813229.

Fouladi M, Stewart CF, Blaney SM, Onar-Thomas A, et al. A Phase II and Molecular Biology Trial of Lapatinib in Children with Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study. Journal of Neuro-Oncology 114(2):173-9, 2013. PMID: 23836190.

Palmer SL, Armstrong C, Onar-Thomas A, Wu S, Wallace D, Bonner MJ, Schreiber J, Swain M, Chapieski L, Mabbott D, Knight S, Boyle R, Gajjar A. Processing speed, attention and working memory after treatment for medulloblastoma: An international, prospective and longitudinal study. Journal of Clinical Oncology 31(28):3494-500, 2013. PMID: 23980078.

Yang JJ, Lim J, Huang J, Bass J, Wu J, Wang C, Fang J, Stewart E, Robinson G, Evans W, Pappo A, Zuo J, Relling MV, Onar-Thomas A, Gajjar A, Stewart CF. Inherited TPMT Genetic Variation and Cisplatin-induced Ototoxicity in Children with Cancer. Clinical Pharmacology & Therapeutics 94(2):252-259. 2013. PMID: 23820299.

Broniscer A, Baker SD, Wetmore C, Pai-Panandiker A, Huang J, Davidoff A, Onar-Thomas A, Panetta JC, Merchant T, Baker J, Kaste S, Gajjar A and Stewart C. Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma. Clinical Cancer Research 19(11): 3050-3058, 2013. PMID: 23536435.

Khan RB, Merchant TE, Boop FA, Sanford AA, Ledet D, Onar-Thomas A, Kun LE. Headache in children with craniopharyngioma. Journal of Child Neurology Nov 8, 2012. Epub ahead of print.

Blaney S, Tagen M, Onar-Thomas A, Berg S, Gururangan S, Scorsone K, Su J, Goldman S, Kieran M, Kun L, Boyett J, Stewart C. A Phase 1 Pharmacokinetic Optimal Dosing Study of Intraventricular Topotecan for Children with Neoplastic Meningitis: A Pediatric Brain Tumor Consortium Study.Pediatric Blood and Cancer 2009. doi: 10.1002/pbc.24309. Epub ahead of print.

Gururangan S, Fangusaro J, Poussaint T, Onar-Thomas A, Gilbertson R, Vajapeyam S, Gajjar A, Goldman S, Friedman H, Packer R, Boyett J, Kun L. Lack of efficacy of Bevacizumab plus Irinotecan in children with recurrent ependymoma – A Pediatric Brain Consortium Study. Journal of Neurooncology 14(11):1404-1412, 2012.

Mueller S, Phillips J, Onar-Thomas A, Romero E, Zheng S, Wiencke JK, McBride SM, Cowdrey C, Prados MD, Weiss WA, Berger MS, Gupta N, Haas-Kogan DA. PTEN promoter methylation and activation of the PI3K/AKT/mTOR pathway in pediatric gliomas and influence on clinical outcome. Journal of Neurooncology 14(9):1146-52, 2012. PMID: 22753230.

Kocak M, Onar-Thomas A. A Simulation Based Evaluation of the Asymptotic Power Formulae for Cox Models in Small Sample Cases. The American Statistician 66(3):173-179, 2012.

Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Becksfort J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. Novel mutations target distinct subgroups of medulloblastoma. Nature 488(7409):43-48. PMID: 22722829.

Jakacki RI, Burger P, Zhou T, Holmes E, Mehmet Kocak, Onar-Thomas A, Goldwein J, Mehta M, Packer R, Tarbell N, Fitz C, Vezina G, Hilden J, Pollack I. Outcome For Children with Metastatic Medulloblastoma Treated with Carboplatin During Craniospinal Radiotherapy and the Impact of Anaplasia: Results Of COG 99701. Journal of Clinical Oncology 30(21):2648-53, 2012. PMID: 22665539.

Paugh BS, Broniscer A, Qu C, Miller C, Zhang J, Tatevossian RG, Olson JM, Geyer JR, Chi S, Saba da Silva N, Onar-Thomas A, Baker J, Gajjar A, Ellison DW, Baker SJ. Genome-wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma. Journal of Clinical Oncology 29(30):3999-4006, 2011. PMID: 21931021.

Fouladi M, Stewart C, Olson J, Wagner L, Onar-Thomas A, Kocak M, Packer R, Goldman S, Gururangan S, Gajjar A, Demuth T, Kun L, Boyett JM, Gilbertson R. A Phase I Trial Of MK0752 In Children With Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study. Journal of Clinical Oncology 29(26):3529-34, 2011. PMID: 21825264.

Fortenbaugh D, Fleisig G, Onar-Thomas A, Asfour S. The Effect of Pitch Type on Ground Reaction Forces in the Baseball Swing. Sports Biomechanics 10(4):270-279, 2011.

Eltoukhy M, Asfour S, Onar-Thomas A. Comparison between Metallic and Allograft Knee Prosthesis Using Musculoskeletal Modeling. International Journal for Computational Vision and Biomechanics 4(1):1-9, 2011.

Last update: September 2014