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Jamy C. Peng, PhD
Jamy C. Peng, PhD


PhD – University of California at Berkeley, Berkeley, CA
Postdoctoral studies – Stanford University, Stanford, CA and Yale University, New Haven, CT

Honors & Awards

  • 2018  American Cancer Society Research Scholar
  • 2012  NIH K99/R00 Pathway to Independence Award
  • 2008  American Cancer Society Postdoctoral Fellowship
  • 2007  NIH Interdisciplinary Postdoctoral Training Grant in Regenerative Medicine

Research Interests

  • Proteins and RNAs in epigenetic programming of stem cell functions
  • Epigenetic mechanisms influencing gene expression changes
  • Epigenetic regulation of stem cell functions

Selected Publications

Matsui Y, Djekidel MN, Lindsay K, Samir P, Connolly N, Wu G, Yang X, Fan Y, Xu B, Peng JC. SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development. Nat Commun Aug 8;14(1):4754, 2023.

Matsui Y, Peng JC. CUT & RUN to Profile Chromatin-Bound Proteins in Primary Mouse Neural Progenitor Cells. Methods Mol Biol 2599:99-111, 2022.

Xu B, Mulvey B, Salie M, Yang X, Matsui Y, Nityanandam A, Fan Y, Peng JC. UTX/KDM6A suppresses AP-1 and a gliogenesis program during neural differentiation of human pluripotent stem cells. Epigenetics Chromatin 13(1):38, 2020.

Evans MK, Matsui Y, Xu B, Willis C, Loome J, Milburn L, Fan Y, Pagala V, Peng JC. Ybx1 fine-tunes PRC2 activities to control embryonic brain development. Nat Commun. 11(1):4060, 2020.

Yang X, Xu B, Mulvey B, Evans M, Jordan S, Wang YD, Pagala V, Peng J, Fan Y, Patel A, Peng JC. Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1. Nat Neurosci. 22(3):362-373, 2019.

Klein JD, Qu C, Yang X, Fan Y, Tang C, Peng JC. C-Fos repression by Piwi regulates Drosophila ovarian germline formation and tissue morphogenesis. PLOS Genet 12(9): e1006281, 2016.

Peng JC*#, Valouev A#, Liu N, Lin H. Piwi negatively regulates Polycomb Group proteins in maintaining germline stem cells and oogenesis. *co-corresponding authors. # co-first authors. Nature Genetics 48(3):283-91, 2016. 

Peng JC, Lin H. Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism. Curr Opin Cell Biol 25(2):190-194, 2013.

Peng JC, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, Wysocka J. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 139(7):1290-1302, 2009. *Highlighted in Cell Stem Cell, Genes & Development, and Faculty of 1000.

Peng JC, Karpen GH. Heterochromatic genome stability requires regulators of histone H3 K9 methylation. PLoS Genet 5(3):e1000435, 2009.

Peng JC, Karpen GH. Epigenetic regulation of heterochromatic DNA stability. Curr Opin Genet Dev 18(2):204-11, 2008.

Peng JC, Wysocka J. It takes a PHD to SUMO. Trends Biochem Sci 33(5):191-194, 2008.

Peng JC, Karpen GH. H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability. Nat Cell Biol 9(1):25-35, 2007. *Highlighted in Cell, Nat Cell Biol, and Faculty of 1000.

Gallie DR, Fortner D, Peng J, Puthoff D. ATP-dependent hexameric assembly of the heat shock protein Hsp101 involves multiple interaction domains and a functional C-proximal nucleotide-binding domain. J Biol Chem 277(42):39617-39626, 2002.

Last update: August 2023