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Sara Rashkin, PhD

Sara Rashkin, PhD

  • Bioinformatics Research Scientist, Genetics

Education

Postdoctoral Scholar, Epidemiology and Biostatistics - University of California, San Francisco, San Francisco, CA
PhD, Biostatistics - University of Michigan, Ann Arbor, MI
MS, Biostatistics - University of Michigan, Ann Arbor, MI
BA, Statistics - Northwestern University, Evanston, IL

About

Dr. Sara Rashkin is a statistical geneticist with both theoretical and applied experience of the analysis of large genetic datasets. She completed her MS and PhD in Biostatistics under the supervision of Dr. Gonçalo Abecasis at the University of Michigan, and, for her postdoctoral training, she joined the lab of Dr. John Witte in the Department Epidemiology and Biostatistics at the University of California, San Francisco.

Research Interests

  • Statistical genetics
  • Genetic epidemiology
  • Methods development and application
  • Design and analysis of studies investigating the role genetics plays in disease

Selected Publications

Emami NC, Cavazos TB, Rashkin SR, Cario CL, Graff RE, Tai CG, Mefford JA, Kachuri L, Wan E, Wong S, Aaronson DS, Presti J, Habel LA, Shan J, Ranatunga DK, Chao CR, Ghai NR, Jorgenson E, Sakoda LC, Kvale MN, Kwok P, Schaefer C, Risch N, Hoffmann TJ, Van Den Eeden SK, Witte JS. A large-scale association study detects novel rare variants, risk genes, functional elements, and polygenic architecture of prostate cancer susceptibility. Cancer Res Dec 8, 2020; [Epub ahead of print]. doi: 10.1158/0008-5472.CAN-20-2635. PMID: 33293427.

Kachuri L, Graff RE, Smith-Bryne K, Meyers TJ, Rashkin SR, Ziv E, Witte JS, Johansson M. Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction. Nat Commun Nov 27;11(1):6084, 2020. doi: 10.1038/s41467-020-19600-4. PMID: 33247094.

Kachuri L, Francis SS, Morrison M, Cavazos TB, Rashkin SR, Ziv E, Witte JS. The landscape of host genetic factors involved in immune response to common viral infections. Genome Med Oct 27;12(1):93. 2020. doi: 10.1186/s13073-020-00790-x. PMID: 33109261

Rashkin SR*, Graff RE*, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH, Meyers TJ, Van Den Eeden SK, Ziv E, Habel LA, Hoffmann TJ, Sakoda LC, Witte JS. Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts. Nat Commun Sep 4;11(1):4423, 2020. doi: 10.1038/s41467-020-18246-6. PMID: 32887889.

Chua KC, Xiong C, Ho C, Mushiroda T, Jiang C, Mulkey F, Lai D, Schneider BP, Rashkin SR, Witte JS, Friedman PN, Ratain MJ, McLeod HL, Rugo HS, Shulman LN, Kubo M, Owzar K, Kroetz DL. Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy. Clin Pharmacol Ther. Sep;108(3):625-634, 2020. doi: 10.1002/cpt.1958. PMID: 32562552.

Graff, RE, Cavazos TB, Thai KK, Kachuri L, Rashkin SR, Hoffman JD, Alexeeff SE, Blatchins M, Meyers TJ, Leong L, Tai CG, Emami NC, Corley DA, Kushi LH, Ziv E, Van Den Eeden SK, Jorgenson E, Hoffmann TJ, Habel LA, Witte JS, Sakoda LC. Cross-Cancer Evaluation of Polygenic Risk Scores for 17 Cancer Types in Two Large Cohorts. 2020; bioRxiv 2020.01.18.911578; doi: 10.1101/2020.01.18.911578. Nat Commun (under review).

Hartman KA, Rashkin SR, Witte JS, Hernandez RD. Imputed Genomic Data Reveals a Moderate Effect of Low Frequency Variants to the Heritability of Complex Human Traits. 2019; bioRxiv 12.18.879916; doi: 10.1101/2019.12.18.879916. Nat Genet (under review).

Kachuri L, Johansson M, Rashkin SR, Graff RE, Bossé Y, Manem V, Caporaso NE, Landi MT, Christiani DC, Vineis P, Liu G, Scelo G, Zaridze D, Shete SS, Albanes D, Aldrich MC, Tardón A, Rennert G, Chen C, Goodman GE, Doherty JA, Bickeböller H, Field JK, Davies MP, Teare MD, Kiemeney LA, Bojesen SE, Haugen A, Zienolddiny S, Lam S, Marchand LL, Cheng I, Schabath MB, Duell EJ, Andrew AS, Manjer J, Lazarus P, Arnold S, McKay JD, Emami NC, Warkentin MT, Brhane Y, Obeidat M, Martin RM, Relton C, Smith GD, Haycock PC, Amos CI, Brennan P, Witte JS, Hung RJ. Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. Nat Commun. Jan 7;11(1):27, 2020. doi: 10.1038/s41467-019-13855-2. PMID: 31911640

Rashkin SR, Chua KC, Ho C, Mulkey F, Jiang C, Mushiroda T, Kubo M, Friedman PN, Rugo HS, McLeod HL, Ratain MJ, Castillos F, Naughton M, Overmoyer B, Toppmeyer D, Witte JS, Owzar K, Kroetz DL. A Pharmacogenetic prediction model of progression-free survival in breast cancer using genome-wide genotyping data from CALGB 40502 (Alliance). Clin Pharmacol Ther. Mar;105(3):738-745, 2019. doi: 10.1002/cpt.1241. PMID: 30260474

Rashkin S, Jun G, Chen S, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), and Abecasis G. Optimal strategies for identifying disease-related singletons. PLoS Genetics. 2017 June;13(6):e1006811, 2017. doi: 10.1371/journal.pgen.1006811. PMID: 28640830

Rashkin S, Rouster S, Goodman ZD, Sherman KE.  T-helper cells and liver fibrosis in hepatitis C virus-monoinfected patients.  J Viral Hepat. Mar;17(3):222-6, 2010. doi: 10.1111/j.1365-2893.2009.01173.x. PMID: 19709360

Full List of Publications

Last update: January 2021