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Shengdar Tsai, PhD

Associate Member, St. Jude Faculty

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Contact Information

Shengdar Tsai, PhD

Experimental Hematology

MS 355, Room D3022B

St. Jude Children's Research Hospital

262 Danny Thomas Place

Memphis,  TN 38195-3678

(901) 595-0407(phone)

(901) 595-2176(fax)

Quick Facts

Tsai was awarded a contract by The Advanced Research Projects Agency for Health in 2026.

Tsai was one of 18 St. Jude investigators recognized on the 2025 Web of Science (TM) list of highly cited researchers. 

Affiliations

Department of Hematology

St. Jude Graduate School of Biomedical Sciences

Comprehensive Cancer Center

Experimental Hematology

Cancer Biology Program

Education

BS – University of Michigan MS – North Carolina State University PhD – North Carolina State University Fellowship – Harvard Medical School / Massachusetts General Hospital

Research Interests

  • Genome Engineering
    • Improving genomic methods to define and measure gene editing “off-target” effects
    • Protein engineering of CRISPR-Cas nucleases for precise gene correction
    • Regulation of DNA damage repair choice between error-prone non-homologous end-joining and precise homology-directed repair
  • Hematology
    • Genome-scale CRISPR-Cas screening for novel effectors of hematological diseases
    • Developing novel strategies for allele-specific editing of genetic mutations that cause sickle cell disease and other hematological disorders

Dr. Tsai in Progress

Dr. Tsai in St. Jude News

St. Jude Publications

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