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Marc Valentine

Marc Valentine

  • Director, Cytogenetics Shared Resource


Research interests

Using cellular genetic methods to understand tumor development.

Selected Publications

Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Deqing P, McCastalin K, Valentine MB, et al. The landscape of kinase activating lesions in acute lymphoblastic leukemia. NEJM 2014 (in press).

McEvoy J, Nagahawatte P, Finkelstein D, Richards-Yutz J, Valentine M, Ma J, Mullighan C, Song G, Chen X, etal: RB1 Gene inactivation by chromothripsis in human retinoblastoma. Oncotarget 5(2):438-40, 2014. PMID: 24509483

Li C, Qi R, Singleterry, Hyle J, Balch A, Li X, Sublett J, Berns H, Valentine M, Valentine V, Sherr CJ, et al. Simultaneous gene editing by injection of mRNAs encoding transcription activator-like effector nucleases into mouse zygotes. Mol Cell Biol 34:1649-58, 2014. PMID: 24567370

Chen X, Stewart E, Shelat AA, Qu C, Bahrami A, Hatley M, Wu G, Bradley C, McEvoy J, Pappo A, Spunt, S, Valentine MB, etal. Targeting oxidative stress in embryonal rhabdomyosarma. Cancer Cell24(6):710-24, 2013. PMID: 24332040.

Liu Z, Walters BJ, Owen T, Brimble MA, Steigelman KA, Zhang L, Mellado Lagarde MM, Valentine MB, Yu Y, Cox BC, Zuo J. Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium. J Neurosci 32(31):10530-40, 2012. PMID: 22855803.

Nathwani AC, Rosales C, McIntosh J, Rastegarlari G, Nathwani D, Raj D, Nawathe S, Waddington SN, Bronson R, Jackson S, Donahue RE, High KA, Mingozzi F, Ng CY, Zhou J, Spence Y, McCarville MB, Valentine M, Allay J, Coleman J, Sleep S, Gray JT, Nienhuis AW, Davidoff AM. Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with Serotype 5 and 8 capsid proteins. Mol Ther Jan 18, 2011. [Epub ahead of print]. PMID: 21254849.

Yu Y, WeberT,Yamashita T, Liu Z, Valentine MB, Cox BC, Zuo J. In vivo proliferation of postmitotic cochlear supporting cells by acute abalation of the retinoblastoma protein in neonatal mice. J Neurosci30:5927-5936, 2010. PMID: 20427652.

Weber T, Corbett MK, Chow LM, Valentine MB, Baker SJ, Zuo J. Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells. Proc Natl Acad Sci USA 105:781-785, 2008. PMID: 18178626.

Zindy F, Uziel T, Ayrault O, Calabrese C, Valentine M, Rehg JE, Gilbertson RJ, Sherr CJ, Roussel MF. Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res 67:2676-2684, 2007. PMID: 17363588.

Hu D, Valentine M, Kidd VJ, Lahti JM. CDK11(p58) is required for the maintenance of sister chromatid cohesion. J Cell Sci 120:2424-2434, 2007. PMID: 17606997.

Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med 6:529-535, 2000. PMID: 10802708.

Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist KA, Genovese C, Bernard A, Ferguson M, Zuo L, Snyder E, Buckler AJ, Wise C, Ashley J, Lovett M, Valentine MB, Look AT, Gerald W, Housman DE, Haber DA. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci USA 95:13765-13770, 1998. PMID: 9811875.

Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Oncogene 12:265-275, 1996. PMID: 8570204.

Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin’s lymphoma. Science 263:1281-1284, 1994. PMID: 8122112.

Khatib ZA, Matsushime H, Valentine M, Shapiro DN, Sherr CJ, Look AT. Coamplification of the CDK4gene with MDM2 and GLI in human sarcomas. Cancer Res 53:1-7, 1993. PMID: 8221695.

Johnson MR, Look AT, DeClue JE, Valentine MB, Lowy DR. Inactivation of the NF1 gene in human malenoma and neuroblastoma cell lines without impaired regulation of GTP Ras. Proc Natl Acad Sci USA 90:5539-5543, 1993. PMID: 8516298.

Shapiro DN, Valentine MB, Rowe ST, Sinclair AE, Sublett JE, Roberts WM, Look AT. Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma. Am J Pathol 142:1339-1346, 1993. PMID: 7684192.

Morishita K, Parganas E, William CL, Whittaker MH, Drabkin H, Oval J, Taetle R, Valentine MB, Ihle JN. Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26. Proc Natl Acad Sci USA 89:3937-3941, 1992. PMID: 1570317.

Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics 13:565-574, 1992. PMID: 1386335.

Hunt JD, Valentine M, Tereba A. Excision of N-myc from chromosome 2 in human neuroblastoma cells containing amplified N-myc sequences. Mol Cell Biol 10:823-829, 1990. PMID: 2405257.

Douglass EC, Rowe ST, Valentine M, Parham D, Meyer WH, Thompson EI. A second nonrandom translocation, der(16)(t(1;16)(q21;q13), in Ewing sarcoma and peripheral neuroectodermal tumor.Cytogenet Cell Genet 53:87-90, 1990. PMID: 2164462.

Douglass EC, Valentine M, Etcubanas E, Parham D, Webber BL, Houghton PJ, Houghton JA, Green AA. A specific chromosomal abnormality in rhabdomyosarcoma. Cytogenet Cell Genet 45:1248-155, 1987. PMID: 3691179.

Last update: September 2014