Peter Vogel, DVM, PhD
Peter Vogel, DVM, PhD

Peter Vogel, DVM, PhD

Member, St. Jude Faculty

  • Director, Veterinary Pathology Core Laboratory

Departments

Education

ACVP, Diplomate – US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland (1994)
PhD – University of California, Davis, California (1993)
DVM – Purdue University, West Lafayette, Indiana (1983)
BS – Brigham Young University, Provo, Utah (1980)

Research Interests

  • Mouse models of human disease
  • Innate immunity and inflammation
  • Pathogenesis of infectious diseases
  • Neurodegenerative disorders

Selected Publications

Yang K, Blanco DB, Neale G, Vogel P, Avila J, Clish CB, Wu C, Shrestha S, Rankin S, Long L, Kc A, Chi H. Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling. Nature 548:602-6, 2017.

Vogel P, Janke L, Gravano DM, Lu M, Sawant DV, Bush D, E S, Vignali DAA, Pillai A, Rehg JE. Globule Leukocytes and Other Mast Cells in the Mouse Intestine. Vet Pathol 300985817705174, 2017.

Karki R, Man SM, Malireddi RK, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P, Kanneganti TD. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature 2016.

Vogel P, Read RW, Hansen GM, Powell DR, Kantaputra PN, Zambrowicz B, Brommage R. Dentin Dysplasia in Notum Knockout Mice. Vet Pathol 53:853-62, 2016.

Vogel P, Gelfman CM, Issa T, Payne BJ, Hansen GM, Read RW, Jones C, Pitcher MR, Ding ZM, DaCosta CM, Shadoan MK, Vance RB, Powell DR. Nephronophthisis and retinal degeneration in tmem218-/- mice: a novel mouse model for senior-loken syndrome? Vet Pathol 52:580-95, 2015.

Lukens JR, Gurung P, Vogel P, Johnson GR, Carter RA, McGoldrick DJ, Bandi SR, Calabrese CR, Vande Walle L, Lamkanfi M, Kanneganti TD. Dietary modulation of the microbiome affects autoinflammatory disease. Nature 516:246-9, 2014.

Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, Beyaert R, Elewaut D, Kanneganti TD, van Loo G, Lamkanfi M. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature 512:69-73, 2014.

Zaki MH, Man SM, Vogel P, Lamkanfi M, Kanneganti TD. Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection. Proc Natl Acad Sci U S A 111:385-90, 2014.

Brommage R, Liu J, Hansen GM, Kirkpatrick LL, Potter DG, Sands AT, Zambrowicz B, Powell DR, Vogel P. High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res 2:14034, 2014.

Lukens JR, Vogel P, Johnson GR, Kelliher MA, Iwakura Y, Lamkanfi M, Kanneganti T-D. RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3. Nature 498:224-7, 2013.

Delgoffe GM, Woo S-R, Turnis ME, Gravano DM, Guy C, Overacre AE, Bettini ML, Vogel P, Finkelstein D, Bonnevier J, Workman CJ, Vignali DAA. Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature 501:252-6, 2013.

Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 499:485-90, 2013.

Anand PK, Malireddi RKS, Lukens JR, Vogel P, Bertin J, Lamkanfi M, Kanneganti T-D. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 488:389-93, 2012.

Vogel P, Hansen GM, Read RW, Vance RB, Thiel M, Liu J, Wronski TJ, Smith DD, Jeter-Jones S, Brommage R. Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice. Vet Pathol 49:998-1017, 2012.

Vogel P, Read RW, Hansen GM, Payne BJ, Small D, Sands AT, Zambrowicz BP. Congenital hydrocephalus in genetically engineered mice. Vet Pathol 49:166-81, 2012.

Van Sligtenhorst I, Ding ZM, Shi ZZ, Read RW, Hansen G, Vogel P. Cardiomyopathy in α-Kinase 3 (ALPK3)-Deficient Mice. Vet Pathol 49:131-41, 2012.

Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 208:1367-76, 2011.

Zaki MH, Vogel P, Malireddi RKS, Body-Malapel M, Anand PK, Bertin J, Green DR, Lamkanfi M, Kanneganti T-D. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 20:649-60, 2011.

Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti T-D. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32:379-91, 2010.

Zaki MH, Vogel P, Body-Malapel M, Lamkanfi M, Kanneganti T-D. IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol 185:4912-20, 2010.

Last update: October 2017