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Ke (Corey) Xu, PhD

Ke (Corey) Xu, PhD

  • Senior Bioinformatics Research Scientist, Genomics

Education

Postdoctoral Fellow - Icahn School of Medicine at Mount Sinai, New York, New York
PhD
 - Georgia Institute of Technology, Atlanta, Georgia 

About

Dr. Ke Xu is a Senior Bioinformatics Research Scientist at St. Jude Children's Research Hospital. He has over 10 years’ experience in molecular evolution, population genetics, and their intersection with complex disease genetics and cancer genomics. His work has been featured in popular media outlets including F1000 and the print edition of Scientific American.

Research Interests

  • Origin and evolution of double minute chromosomes in tumors
  • Tumor heterogeneity and evolution
  • Comparative genomics of human and non-human species

Selected Publications

Smith KS*, Xu K*, Mercer KS, Boop F, Klimo P, DeCupyere M, Grenet J, Robinson S, Dunphy P, Baker SJ, Ellison DW, Merchant TE, Upadayaya SA, Gajjar A, Wu G, Orr BA, Robinson GW, Northcott PA, Roussel MF. 2020. Patient-derived orthotopic xenografts of pediatric brain tumors: a St. Jude resource. Acta Neuropathologica. Jun 10. doi: 10.1007/s00401-020-02171-5. PMID: 32519082. (* equal contribution)

Li B, Brady SW, Ma X, Shen S, Zhang Y, Li Y, Szlachta K, Dong L, Liu Y, Yang F, Wang N, Flasch DA, Myers MA, Mulder HL, Ding L, Liu Y, Tian L, Hagiwara K, Xu K, Zhou X, Sioson E, Wang T, Yang L, Zhao J, Zhang H, Shao Y, Sun H, Sun L, Cai J, Sun HY, Lin TN, Du L, Li H, Rusch M, Edmonson MN, Easton J, Zhu X, Zhang J, Cheng C, Raphael BJ, Tang J, Downing JR, Alexandrov LB, Zhou BS, Pui CH, Yang JJ, and Zhang J. 2020. Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia. Blood, 135: 41-55

Xu K, Ding L, Chang TC, Chiang J, Mulder H, Wang S, Shaw TI, Wen J, Hover L, McLeod C, Wang YD, Easton J, Rusch M, Dalton J, Downing JR, Ellison DW, Zhang J, Baker SJ, Wu G. 2019. Structure and evolution of double minutes in diagnosis and relapse brain tumors. Acta Neuropathologica, 137: 123-137

Patel R, Scheinfeldt LB, Sanderford MD, Lanham TR, Tamura K, Platt A, Glicksberg BS, Xu K, Dudley JT, Kumar S. 2018. Adaptive landscape of protein variation in human exomes. Molecular Biology and Evolution, 35: 2015-2025

Fullard JF, Giambartolomei C, Hauberg ME, Xu K, Voloudakis G, Shao Z, Bare C, Dudley JT, Mattheisen M, Robakis NK, Haroutunian V, Roussos P. 2017. Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci. Human Molecular Genetics, 26: 1942–1951.

Dincer A, Gavin DP, Xu K, Zhang B, Dudley JT, Schadt EE, Akbarian S. 2015. Deciphering H3K4me3 broad domains associated with gene regulatory networks and conserved epigenomic landscapes in the human brain. Translational Psychiatry, 5: e679

Xu K, Schadt EE, Pollard KS, Roussos P, Dudley JT. 2015. Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions. Molecular Biology and Evolution, 32: 1148-1160

Jameson NM, Yi SV, Xu K, Sperone FG, Wildman DE. 2014. The tempo and mode of New World monkey evolution and biogeography in the context of phylogenomic analysis. Molecular Phylogenetics and Evolution, 82: 386-399

Xu K, Wang J, Elango N, Yi SV. 2013. The evolution of lineage-specific clusters of single nucleotide substitutions in the human genome. Molecular Phylogenetics and Evolution, 69: 276-285

Xu K, Oh S, Park T, Presgraves DC, Yi SV. 2012. Lineage-specific variation in slow- and fast-X evolution in primates. Evolution, 66: 1751–1761.

Park J, Xu K, Park T, Yi SV. 2012. What are the determinants of gene expression levels and breadths in the human genome? Human Molecular Genetics, 21: 46-56.

Xu K, Bezakova I, Bunimovich L, Yi SV. 2011. Path lengths in protein-protein interaction networks and biological complexity. Proteomics, 11: 1857-1867. 

Last update: June 2020