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St. Jude – SERCAT
Structural Biology Symposium

Held Thursday – Friday, March 18 – 19, 2021


Overall, this symposium showcased X-ray crystallography and integrative structural biology approaches that continue to transform science and translational medicine. Hosts included the Structural Biology Department at St. Jude Children’s Research Hospital and the Southeast Regional Collaborative Access Team (SER-CAT) at the Advanced Photon Source. This 18th annual SER-CAT user meeting was in support of X-ray crystallography and advancement of synchrotron-based research in meeting tomorrow’s scientific challenges.

Because of COVID, this year's SER-CAT user meeting was held online, affording a unique opportunity for the St. Jude community to attend. You heard from leaders in the structural biology field whose scientific contributions have far-reaching impact with high relevance to the science being conducted at St. Jude.


Keynote Speaker

Portrait of Ian Wilson

Ian Wilson, DPhil

Professor and Chair
Scripps Research


Symposium Host

Portrait of Darcie Miller

Darcie Miller, PhD

Director, X-Ray Crystallography Center
St. Jude Children's Research Hospital


Workshops and Poster Session, Thursday, March 18th

Workshops featured the remote use of SER-CAT (emphasis on automated capabilities enabled by the new K-B focusing mirror system and Eiger 16M detector) and use of partner ALS beamlines during the APS dark period.

View the Workshop Flyer

Time  Event
1:00 - 1:10 pm Director’s Introduction of ALS & SER-CAT Partnership
Prof. Bi-Cheng Wang, Director of SER-CAT, SER-CAT & UGA
1:10 - 4:00 pm Remote data collection at ALS Beamlines 5.0.1,2
Dr. Marc Allaire, Lawrence Berkeley National Lab
4:00 - 5:00 pm Getting the best data from APS Beamline 22ID
Dr. John Chrzas, SER-CAT & UGA
5:00 - 6:00 pm  Poster Session Featuring Prize Winners
Winning student and postdoc posters will be presented. Winners will be available to answer questions and prizes will be announced at the end of the session.

Scientific Meeting, Friday, March 19th

Time Event
8:45 - 9:00 am Log in
9:00 - 9:10 am Welcome
Dr. Darcie Miller, St. Jude Children's Research Hospital
9:10 - 9:15 am Opening Remarks
Dr. Scott Blanchard, St. Jude Children's Research Hospital
Session 1: General Scientific Talks and Keynote Speaker
Session Chair: Dr. Stephen White
9:15 - 9:40 am Enhancing Chemotherapy with Small Molecule Translesion Synthesis Inhibitors
Dr. Pei Zhou, Duke University
9:40 - 10:05 am The mechanistic origins of spacer acquisition in CRISPR-Cas: Repurposing DNA Transposition
Dr. Fred Dyda, NIDDK, National Institutes of Health
10:05 - 10:30 am Disrupting a key H-bond network drives glucocorticoid receptor gene suppression without off-target gene activation
Dr. Eric Ortlund, Emory University
10:30 - 10:45 am Break
10:45 - 10:50 am Introduction of Keynote Speaker
Dr. Stephen White, St. Jude Children’s Research Hospital
10:50 - 11:50 am Structural insights into antibody responses to SARS-CoV-2 and escape mutations
Keynote Speaker: Dr. Ian A. Wilson, Scripps Research
11:50 am - 1:00 pm Break for lunch following brief announcement by Dr. Darcie Miller
Session 2: SER-CAT Award Winners, SER-CAT & APS Updates
Session Chair: Dr. Raquel Lieberman
1:00 - 1:05 pm Return from lunch
1:05 - 1:15 pm SER-CAT Remarks and Introduction of APS Speaker
Prof. Bi-Cheng Wang, Director of SER-CAT, SER-CAT & UGA
1:15 - 1:45 pm The Advanced Photon Source Upgrade Project – an update
Dr. Dennis Mills, APS, Argonne National Laboratory
1:45 - 2:10 pm Endogenous DNA 3' blocks are vulnerabilities for BRCA1 and BRCA2 deficiency and are reversed by the APE2 family nucleases
Dr. R. Scott Williams, NIEHS, National Institutes of Health
2:10 - 2:35 pm The regulatory role of tRNAs in translation
Ha An Nguyen, Emory University
2:35 - 2:45 pm SER-CAT Award Presentations
Prof. Bi-Cheng Wang, Director of SER-CAT, SER-CAT & UGA
2:45 - 3:00 pm Break
3:00 - 3:25 pm SER-CAT upgrade update
Dr. John Chrzas, SER-CAT & UGA
Session 3: SER-CAT Member Talks
Session Chair: Dr. Tudor Moldoveanu
3:25 - 3:45 pm Molecular architecture glaucoma-associated myocilin
Dr. Raquel Lieberman, Georgia Institute of Technology
3:45 - 4:05 pm Crystal structure of the HRSV M2-1 protein in complex with a short positive-sense gene-end RNA
Dr. Bo Liang, Emory University
4:05 - 4:25 pm Structure and mechanism of Staphylococcus aureus oleate hydratase (OhyA)
Dr. Christopher Radka, St. Jude Children’s Research Hospital
4:25 - 4:30 pm Closing Remarks
Dr. Darcie Miller, St. Jude Children’s Research Hospital