Overall, this symposium showcased X-ray crystallography and integrative structural biology approaches that continue to transform science and translational medicine. Hosts included the Structural Biology Department at St. Jude Children’s Research Hospital and the Southeast Regional Collaborative Access Team (SER-CAT) at the Advanced Photon Source. This 18th annual SER-CAT user meeting was in support of X-ray crystallography and advancement of synchrotron-based research in meeting tomorrow’s scientific challenges.
Because of COVID, this year's SER-CAT user meeting was held online, affording a unique opportunity for the St. Jude community to attend. You heard from leaders in the structural biology field whose scientific contributions have far-reaching impact with high relevance to the science being conducted at St. Jude.
Keynote Speaker
Ian Wilson, DPhil
Professor and Chair
Scripps Research
Symposium Host
Darcie Miller, PhD
Director, X-Ray Crystallography Center
St. Jude Children's Research Hospital
Workshops and Poster Session, Thursday, March 18th
Workshops featured the remote use of SER-CAT (emphasis on automated capabilities enabled by the new K-B focusing mirror system and Eiger 16M detector) and use of partner ALS beamlines during the APS dark period.
| Time | Event |
|---|---|
| 1:00 - 1:10 pm | Director’s Introduction of ALS & SER-CAT Partnership Prof. Bi-Cheng Wang, Director of SER-CAT, SER-CAT & UGA |
| 1:10 - 4:00 pm | Remote data collection at ALS Beamlines 5.0.1,2 Dr. Marc Allaire, Lawrence Berkeley National Lab |
| 4:00 - 5:00 pm | Getting the best data from APS Beamline 22ID Dr. John Chrzas, SER-CAT & UGA |
| 5:00 - 6:00 pm | Poster Session Featuring Prize Winners Winning student and postdoc posters will be presented. Winners will be available to answer questions and prizes will be announced at the end of the session. |
Scientific Meeting, Friday, March 19th
| Time | Event |
|---|---|
| 8:45 - 9:00 am | Log in |
| 9:00 - 9:10 am | Welcome Dr. Darcie Miller, St. Jude Children's Research Hospital |
| 9:10 - 9:15 am | Opening Remarks Dr. Scott Blanchard, St. Jude Children's Research Hospital |
| Session 1: General Scientific Talks and Keynote Speaker Session Chair: Dr. Stephen White |
|
| 9:15 - 9:40 am | Enhancing Chemotherapy with Small Molecule Translesion Synthesis Inhibitors Dr. Pei Zhou, Duke University |
| 9:40 - 10:05 am | The mechanistic origins of spacer acquisition in CRISPR-Cas: Repurposing DNA Transposition Dr. Fred Dyda, NIDDK, National Institutes of Health |
| 10:05 - 10:30 am | Disrupting a key H-bond network drives glucocorticoid receptor gene suppression without off-target gene activation Dr. Eric Ortlund, Emory University |
| 10:30 - 10:45 am | Break |
| 10:45 - 10:50 am | Introduction of Keynote Speaker Dr. Stephen White, St. Jude Children’s Research Hospital |
| 10:50 - 11:50 am | Structural insights into antibody responses to SARS-CoV-2 and escape mutations Keynote Speaker: Dr. Ian A. Wilson, Scripps Research |
| 11:50 am - 1:00 pm | Break for lunch following brief announcement by Dr. Darcie Miller |
| Session 2: SER-CAT Award Winners, SER-CAT & APS Updates Session Chair: Dr. Raquel Lieberman |
|
| 1:00 - 1:05 pm | Return from lunch |
| 1:05 - 1:15 pm | SER-CAT Remarks and Introduction of APS Speaker Prof. Bi-Cheng Wang, Director of SER-CAT, SER-CAT & UGA |
| 1:15 - 1:45 pm | The Advanced Photon Source Upgrade Project – an update Dr. Dennis Mills, APS, Argonne National Laboratory |
| 1:45 - 2:10 pm | Endogenous DNA 3' blocks are vulnerabilities for BRCA1 and BRCA2 deficiency and are reversed by the APE2 family nucleases Dr. R. Scott Williams, NIEHS, National Institutes of Health |
| 2:10 - 2:35 pm | The regulatory role of tRNAs in translation Ha An Nguyen, Emory University |
| 2:35 - 2:45 pm | SER-CAT Award Presentations Prof. Bi-Cheng Wang, Director of SER-CAT, SER-CAT & UGA |
| 2:45 - 3:00 pm | Break |
| 3:00 - 3:25 pm | SER-CAT upgrade update Dr. John Chrzas, SER-CAT & UGA |
| Session 3: SER-CAT Member Talks Session Chair: Dr. Tudor Moldoveanu |
|
| 3:25 - 3:45 pm | Molecular architecture glaucoma-associated myocilin Dr. Raquel Lieberman, Georgia Institute of Technology |
| 3:45 - 4:05 pm | Crystal structure of the HRSV M2-1 protein in complex with a short positive-sense gene-end RNA Dr. Bo Liang, Emory University |
| 4:05 - 4:25 pm | Structure and mechanism of Staphylococcus aureus oleate hydratase (OhyA) Dr. Christopher Radka, St. Jude Children’s Research Hospital |
| 4:25 - 4:30 pm | Closing Remarks Dr. Darcie Miller, St. Jude Children’s Research Hospital |