Patricia M. Flynn, MD
Patricia M. Flynn, MD

Patricia M. Flynn, MD

Member, St. Jude Faculty

  • Senior Vice President and Medical Director of Quality and Patient Care
  • Deputy Clinical Director
  • Chief, Bone Marrow Transplant Clinical Operations
  • Arthur Ashe Chair in Pediatric AIDS Research

Departments

Education

BS – Rhodes College (formerly Southwestern at Memphis), Memphis, Tennessee (1977)
MS – Epidemiology, University of Tennessee, Memphis, College of Graduate Health (2002)
MD – Louisiana State University Medical Center, New Orleans, Louisiana (1981)

Research Interests

  • HIV/AIDS
  • Infections in immunocompromised hosts (mycotic infections and intravascular catheter infections)
  • Epidemiology

Read about AIDS Clinical Trials.

Selected Publications

Havens PL, Stephensen CB, Van Loan MD, Schuster GU, Woodhouse LR, Flynn PM, Gordon CM, Pan CG, Rutledge B, Liu N, Wilson CM, Hazra R, Hosek SG, Anderson PL, Seifert SM, Kapogiannis BG, Mulligan K; Adolescent Medicine Trials Network for HIV/AIDS Interventions 117 study team.. Decline in Bone Mass With Tenofovir Disoproxil Fumarate/Emtricitabine Is Associated With Hormonal Changes in the Absence of Renal Impairment When Used by HIV-Uninfected Adolescent Boys and Young Men for HIV Preexposure Prophylaxis. Clin Infect Dis 64(3):317-325, 2017.

Lyon ME, D'Angelo LJ, Dallas RH, Hinds PS, Garvie PA, Wilkins ML, Garcia A, Briggs L, Flynn PM, Rana SR, Cheng YI, Wang J. A randomized clinical trial of adolescents with HIV/AIDS: pediatric advance care planning. AIDS Care Mar 30:1-10, 2017. [Epub ahead of print]

Fowler, MG, Qin M, Fiscus S, Currier JS, Flynn PM, Chipato T, McIntyre J, Gnanashanmugam D, Siberry GK, Coletti A, Taha T, Klingman KL, Martinson FE, Owor M, Violari A, Moodley D,  Theron GB, Bhosale R, Bobat R, Chi BH, Strehlau R, Mlay P, Loftis AJ, Browning R, Fenton T, Purdue L, Basar M, Shapiro DE, Mofenson LM, for the International Maternal Pediatric and Adolescent AIDS Clinical Trials Group (IMPAACT) 1077BF/1077FF PROMISE Study Team. Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention. N Engl J Med 375(18):1726-1737, 2016.

The BREATHER (PENTA 16) Trial Group. Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescent and young adults (BREATHER): a randomized, open-label, non-inferiority, phase 2/3 trial. Lancet HIV June 20, 2016. http://dx.doi.org/10.1016/S2352-3018(16)30054-6

Hakim H, Allison KJ, Van de Velde LA, Tang L, Sun Y, Flynn PM, McCullers JA. Immunogenicity and safety of high-dose trivalent inactivated influenza vaccine compared to standard-dose vaccine in children and young adults with cancer or HIV infection. Vaccine 34(27):3141-8, 2016.

Lombaard J, Bunupuradah T, Flynn PM, Ramapuram J, Ssali F, Crauwels H, Hoogstoel A, Van Eygen V, Stevens M. Rilpivirine as a Treatment for HIV-infected Antiretroviral-Naïve Adolescents: Week 48 Safety, Efficacy, Virology and Pharmacokinetics. Pediatr Infect Dis J Jun 10, 2016. [Epub ahead of print].

Kapogiannis BG, Leister E, Siberry GK, Van Dyke RB, Rudy B, Flynn P, Williams PL. Prevalence of and Progression to Abnormal Non-Invasive Markers of Liver Disease (APRI and FIB-4) among US HIV-infected Youth. AIDS 30(6):889-98, 2016.

Shenep, MA, Tanner MR, Sun Y, Culley T, Hayden RT, Flynn PM, Tang L, Wolf J. Catheter-related complications in children with cancer receiving parenteral nutrition: Change in risk is moderated by catheter type. JPEN Jan 7, 2016. pii: 0148607115624087. [Epub ahead of print].

Sealy RE, Jones BG, Surman SL, Branum K, Howlett NM, Flynn PM, Hurwitz JL. Murine Monoclonal Antibodies for Antigenic Discrimination of HIV-1 Envelope Proteins. Viral Immunol 29(1):64-70, 2016.

Hakim H, Dallas R,  Zhou Y, Pei 2, Cheng C, Flynn PM, Pui C-H, Jeha S. Acute Respiratory Infections in Children and Adolescents with Acute Lymphoblastic Leukemia. Cancer 122(5):798-805, 2016.

Wolf J, Tang L, Rubnitz JE, Brennan RC, Shook DR, Stokes DC, Monagle P, Curtis N, Worth LJ, Allison K, Sun Y, Flynn PM. Monitoring Central Venous Catheter Resistance to Predict Imminent Occlusion: A Prospective Pilot Study. PLoS One Aug 31;10(8):e0135904, 2015. doi: 10.1371/journal.pone.0135904. eCollection 2015.

Apiwattankul N, Flynn PM, Hayden RT, Adderson AA. Infections caused by rapidly growing Mycobacteria spp in children and adolescents with cancer. J Pediatr Infect Dis 4:104-113, 2015.

Ojha RP, Stallings-Smith S, Flynn PM, Adderson EE, Offutt-Powell TN, Gaur AH. The Impact of Vaccine Concerns on Racial/Ethnic Disparities in Influenza Vaccine Uptake Among Health Care Workers. Am J Public Health Jul 16:e1-e7, 2015. [Epub ahead of print] PMID: 26180953.

Curtis DJ, Muresan P, Nachman S, Fenton T, Richardson KM, Dominguez T, Flynn PM, Spector SA, Cunningham CK, Bloom A, Weinberg A. Characterization of Functional Antibody and Memory B-cell Responses to pH1N1 Monovalent Vaccine in HIV-infected Children and Youth. P PLoS One 10(3):e0118567, 2015.

Wolf J, Allison KJ, Tang L, Sun Y, Hayden RT, Flynn PM. No evidence of benefit from antibiotic lock therapy in pediatric oncology patients with central line-related bloodstream infection: results of a retrospective matched cohort study and review of the literature. Pediatr Blood Cancer 61(10):1811-5, 2014.

Hicks JK, Crews KR, Flynn P, Haidar CE, Daniels CC, Yang W, Panetta JC, Pei D, Scott JR, Molinelli AR, Broeckel U, Bhojwani D, Evans WE, Relling MV. Voriconazole plasma concentrations in immunocompromised pediatric patients vary by CYP2C19 diplotypes. Pharmacogenomics 15(8):1065-78, 2014.

Carter R, Wolf J, van Opijnen T, Muller M, Obert C, Burnham C, Mann B, Li Y, Hayden RT, Pestina T, Persons D, Camilli A, Flynn PM, Tuomanen EI, Rosch JW. Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions. Cell Host Microbe 15:587, 2014.

Flynn P, Komar S, Blanche S, Giaquinto C, Noguera-Julian A, Welch S, Lathouwers E, Van de Casteele T, Kakuda T, Opsomer M.   Efficacy and Safety of Darunavir/Ritonavir at 48 Weeks in Treatment-naïve, HIV-1–infected Adolescents Results From a Phase 2 Open-label Trial (DIONE). Pediatr Infect Dis J 33(9):940-5, 2014.

Havens PL, Hazra R, Stephensen CB, Kiser JJ, Flynn PM, Wilson CM, Rutledge B, Bethel J, Pan CG, Woodhouse LR, Van Loan MD, Liu N, Lujan-Zilbermann J, Baker A, Kapogiannis BG, Gordon CM, Mulligan K; the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) 063 study team. Vitamin D3 supplementation increases fibroblast growth factor-23 in HIV-infected youth treated with tenofovir disoproxil fumarate. Antivir Ther Feb 17, 2014. [Epub ahead of print]

Inaba H, Gaur AH, Cao X, Flynn PM, Pounds SB, Avutu V, Marszal LN, Howard SC, Pui CH, Ribeiro RC, Hayden RT, Rubnitz JE. Feasibility, efficacy, and adverse effects of outpatient antibacterial prophylaxis in children with acute myeloid leukemia. Cancer 120(13):1985, 2014.

Porter TR, Li X, Stephensen CB, Mulligan K, Rutledge B, Flynn PM, Lujan-Zilbermann J, Hazra R, Wilson CM, Havens PL, Tang J for the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) 063 study team. Genetic associations with 25-hydroxyvitamin D deficiency in HIV-1-infected youth: fine-mapping for the GC/DBP gene that encodes the vitamin D-binding protein. Front Genet 4:234, 2013.

Lee S, Kapogiannis BG, Flynn PM, Rudy BJ, Bethel J, Ahmad S, Tucker D, Abdalian SE, Hoffman D, Wilson CM, Cunningham CK; Adolescent Medicine Trials Network for HIV/AIDS Interventions. Comprehension of a simplified assent form in a vaccine trial for adolescents. J Med Ethics 39:410, 2013.

Committee on Pediatric AIDs. Infant feeding and transmission of human immunodeficiency virus in the United States. Pediatrics 131:391, 2013.

Committee On Pediatric AIDs. Transitioning HIV-infected youth into adult health care. Pediatrics 132:192, 2013.

Wolf J, Curtis N, Worth LJ, Flynn PM. Central line-associated bloodstream infection in children: an update on treatment. Pediatr Infect Dis J 32:905, 2013.

Siberry GK, Abzug MJ, Nachman S, Brady MT, Dominguez KL, Handelsman E, Mofenson LM, Nesheim S; and the Panel on Opportunistic Infections in HIV-Exposed and HIV-Infected Children (Bhattacharya D; Bohannon B; Clarke D.; Edwards KM; Esbenshade JC; Flynn P; Gaur A; Gigliotti F; Harrison G; Hobbs CV; Kimberlin D; Kleiman MB; Koumans EH; Kroger A; Levin MJ; Mack CL; Marais BJ; Maron G; McAuley J; Menzies HJ; Moscicki A; Narkewicz MR; Rutstein R; Seward J; Shimamura M; Steinbach WJ; Wilson GJ). Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children: Recommendations from the National Institutes of Health, Centers for Disease Control and Prevention, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics. Pediatr Infect Dis J 32(Supplement 2), 2013.

Havens P, Kiser J, Stephensen C, Hazra R, Flynn P, Wilson C, Rutledge B, Bethel J, Pan C, Woodhouse L, van Loan M, Liu N, Lujan-Zilbermann J, Baker A, Kapogiannis B, Gordon C, Mulligan K. Association of higher plasma vitamin D binding protein and lower free calcitriol with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: Cause of a functional vitamin D deficiency? Antimicrob Agents Chemother 57:5619-28, 2013.

Maron GM, Hayden RT, Rodriguez A, Rubnitz JR, Flynn PM, Shenep JL, Knapp KM. Voriconazole Prophylaxis in Children with Cancer: Changing Outcomes and Epidemiology of Fungal Infections. Pediatr Infect Dis J 32:e451, 2013.

Bernardo VA, Cross SJ, Crews KR, Flynn PM, Hoffman JM, Knapp KM, Pauley JL, Molinelli AR, Greene WL. Posaconazole therapeutic drug monitoing in pediatric patients and young adults with cancer. Ann Pharmocother ePub June 4, 2013.

Pass RF, Nachman S, Flynn PM, Muresan P, Fenton T, Cunningham CK, Borkowsky W, McAuley JB, Spector SA, Petzold E, Levy W, Siberry GK, Handelsman E, Utech LJ, Weinberg. Immunogenicity of licensed influenza A (H1N1) 2009 monovalent vaccines in HIV-infected children and youth (IMPAACT P1089). J Pediatr Infect Dis Soc 2:352, 2013.

Show More

Weinberg A, Muresan P, Fenton T, Richardson K, Dominguez T, Bloom A, Petzold E, Anthony P, Cunningham C, Spector S, Nachman S, Siberry G, Handelsman E, Miller J, Flynn P for IMPAACT P1088 study team. High proportions of regulatory B and T cells are associated with decreased cellular responses to PH1N1 influenza vaccine in HIV-infected children and youth (IMPAACT P1088). Hum Vaccin Immunother 9:957, 2013.

Wolf J, Shenep JL, Clifford V, Curtis N, Flynn PM. Ethanol lock therapy in pediatric hematology and oncology. Pediatr Blood Cancer 60:18-25, 2013.

Minniear TD, Gaur AH, Thridandapani A, Sinnock C, Tolley EA, Flynn PM. Delayed Entry into and Failure to Remain in HIV Care Among HIV-Infected Adolescents. AIDS Res Hum Retroviruses 29:99-104, 2013.

Hoffman JM, Frediani J, Herr M, Flynn PM, Adderson EA, Safety of Cefepime and Ceftazidime in Pediatric Oncology Patients. Pediatri Blood Cancer 60(5):806, 2013.

Gaur AH, Flynn PM, Bitar W, Liang H. Optimizing Frequency of CD4 Assays in the Era of Highly Active Antiretroviral Therapy. AIDS Res Hum Retroviruses 29:423, 2013.

Srinivasan A, Flynn P, Gu Z, Hartford C, Lovins R, Sunkara A, Srivastava DK, Leung W, Hayden RT.  Detection of respiratory viruses in asymptomatic children undergoing allogeneic hematopoietic cell transplantation. Pediatr Blood Cancer 60:149-51, 2013.

Last update: June 2017