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Bryan A. Gibson, PhD
Bryan A. Gibson, PhD

Bryan A. Gibson, PhD

Assistant Member, St. Jude Faculty



Postdoctoral Fellow – UTSW Medical Center
PhD, Philosophy (Molecular Biophysics) – UTSW Medical Center 
Graduate Student – Cornell University and UTSW Medical Center
Research Associate – University of California at Davis
BS (Genetics) – University of California at Davis

Honors & Awards

  • 2018  Ruth L. Kirschstein National Research Service Award
  • 2010  American Heart Association Predoctoral Fellow

Research Interests

  • Spatial order and assembly of chromosomes
  • Cellular compartment formation through phase separation
  • DNA nanoscopy and chromatin structure
  • Biochemical reconstitution of nuclear functions

Selected Publications

Schneider MWG, *Gibson BA, *Otsuka S, Spicer MFD, Petrovic M, Blaukopf C, Langer CCH, Batty P, Nagaraju T, Doolittle LK, Rosen MK, Gerlich DW. A mitotic chromatin phase transition prevents perforation by microtubules. Nature Sep;609(7925):183-190, 2022. 10.1038/s41586-022-05027-y (*co-authorship)

Strohkendl I, Saifuddin FA, Gibson BA, Rosen MK, Russell R, Finkelstein IJ. Inhibition of CRISPR-Cas12a DNA Targeting by Nucleosomes and Chromatin. Science Advances 7(11):eabd6030, 2021.

*Parsons LHP, *Challa S, *Gibson BA, Nandu T, Stokes MS, Huang D, Lea JS, Kraus WL. Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells. eLife 10:e60481, 2021. (*co-authorship)

Conrad LB, Lin KY, Nandu T, Gibson BA, Lea JS, Kraus WL. ADP-ribosylation Levels and Patterns Correlate with Gene Expression and Clinical Outcomes in Ovarian Cancers. Molecular Cancer Therapeutics Jan;19(1):282-291, 2020.

Gibson BA, Doolittle LK, Schneider MWG, Jensen LE, Gamarra N, Henry L, Gerlich DW, Redding S, Rosen MK. Organization of Chromatin by Intrinsic and Regulated Phase Separation. Cell Oct 3;179(2):470-484, 2019.

Rogge RA, Gibson BA, Kraus WL. Identifying Genomic Sites of ADP-Ribosylation Mediated by Specific Nuclear PARP Enzymes Using Click-ChIP. Methods in Molecular Biology 1813:371-387, 2018.

Gibson BA, Conrad LB, Huang D, Kraus WL. Generation and Characterization of Recombinant Antibody-like ADP-ribose Binding Proteins. Biochemistry Dec 5;56(48):6305-6316, 2017.  

Gibson BA, Kraus WL. Identification of Protein Substrates of Specific PARP Enzymes Using Analog-Sensitive PARP Mutants and a “Clickable” NAD+ Analog. Methods in Molecular Biology 1608:111-135, 2017.

Luo X, Ryu KW, Kim DS, Nandu T, Medina CJ, Gupte R, Gibson BA, Soccio RE, Yu Y, Gupta RK, Kraus WL. PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. Molecular Cell Jan 19;65(2):260-271, 2017.

Gibson BA, Zhang Y, Jiang H, Hussey KM, Shrimp JH, Lin H, Schwede F, Yu Y, Kraus WL. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science Jul 1;353(6294):45-50, 2016.

Liu J, Doty T, Gibson B, Heyer WD. Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nature Structural and Molecular Biology 17:1260-1262, 2010.

Last update: November 2022