Douglas Green, PhD
Douglas R. Green, PhD

Douglas R. Green, PhD

Member, St. Jude Faculty

  • Chair, Immunology Department
  • Peter C. Doherty Endowed Chair of Immunology



PhD – Yale University, New Haven, Connecticut (1981)

Research Interests

Central mechanisms of apoptosis in cancer and the immune system

Selected Publications

Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT. Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration. Nat Cell Biol April 29, 2012.

Chipuk JE, McStay GP, Bharti A, Kuwana T, Clarke CJ, Siskind LJ, Obeid LM, Green DR. Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell 148(5):988-1000, 2012.

Bender CE, Fitzgerald P, Tait SWG, Llambi F, McStay GP, Tupper DO, Pellettieri J, Alvarado AS, Salvesen GS, Green DR. Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A 109(13):4904-9, 2012.

Wolkers MC, Gerlach C, Arens R, Janssen EM, Fitzgerald P, Schumacher TN, Medema JP, Green DR, Schoenberger SP. Nab2 regulates secondary CD8(+) T-cell responses through control of TRAIL expression. Blood 119(3):798-804, 2012.

Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell October 25, 2011.

Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS. RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell 44(1):9-16, 2011.

Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green DR. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci U S A October 3, 2011.

Green DR, Galluzzi L, Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. science 333(6046):1109-1112, 2011.

Yeretssian G, Correa RG, Doiron K, Fitzgerald P, Dillon CP, Green DR, Reed JC, Saleh M. Non-apoptotic role of BID in inflammation and innate immunity. Nature 474(7349):96-126, 2011.

Ferguson TA, Choi J, Green DR. Armed response: how dying cells influence T-cell functions. Immunol Rev 241(1):77-88, 2011.

Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471(7338):363-7, 2011.

Oberst A, Green DR. It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival. Nat Rev Mol Cell Biol 12(11):757-763, 2011.

Green DR. Stress in biomedical research: six impossible things. Mol Cell 40(2):176-8, 2010.

Tait SWG, Green DR. Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 11(9):621-32, 2010.

Tait SWG, Parsons MJ, Llambi F, Bouchier-Hayes L, Connell S, Munoz-Pinedo C, Green DR. Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell 18(5):802-13, 2010.

Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR. The BCL-2 family reunion. Mol Cell 37(3):299-310, 2010.

Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SWG, Dillon CP, Flanagan JM, Beere HM, Green DR. Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell 35(6):830-40, 2009.

Moldoveanu T, Gehring K, Green DR. Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature 456(7220):404-8, 2008.

Sanjuan MA, Dillon C, Tait SWG, Moshiach S, Dorsey F, Connell S, Komatsu M, Tanaka K, Cleveland JL, Withoff S, Green DR. Toll-like receptor signaling in macrophages links the autophagy pathway to phagocytosis. Nature 450(7173):1253-1257, 2007.

Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell 129(5):983-97, 2007.

Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Barbry P, Newmeyer DD, Beere HM, Green DR. GAPDH and autophagy protect cells from caspase-independent cell death. Cell 129:983-997, 2007.

Tu S, McStay GP, Boucher LM, Mak T, Beere HM, Green DR. In situ “trapping” of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Nature Cell Biol 8:72-77, 2006.

Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of Mcl-1. Mol Cell 21, 749-760, 2006.

Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR.Puma couples the nuclear and cytoplasmic pro-apoptotic function of p53. Science 309:1732-1735, 2005.

Janssen EM, Droin NM, Lemmens EE, Pinkoski MJ, Bensinger SJ, Ehst BD, Griffith TS, Green DR and Schoenberger SP. (shared senior authorship) T help controls CD8 T cell memory through regulation of TRAIL-mediated AICD. Nature 434:88-93, 2005.

Chipuk JE, Green DR. Do apoptotic pathways trigger caspase-independent cell death? Nature Rev Mol Cell Biol 6:268-275, 2005.

Green DR. Apoptotic pathways: ten minutes to dead. Cell 121:671-674, 2005.

Spierings D, McStay G, Saleh M, Bender C, Chipuk J, Maurer U, Green DR. Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science 310:66-67, 2005.

Last update: May 2012