Douglas Green, PhD
Douglas R. Green, PhD

Douglas R. Green, PhD

Member, St. Jude Faculty

  • Chair, Immunology Department
  • Co-Leader, Cancer Biology Program
  • Peter C. Doherty Endowed Chair of Immunology

Departments

Education

PhD – Yale University, New Haven, Connecticut (1981)

Honors & Awards

  • 2020  National Academy of Sciences
  • 2019  Wilbur Lucius Cross Medal for Yale Alumni Achievement
  • 2018  Fellow, Royal Society of Canada
  • 2018  NCI Outstanding Investigator Award
  • 2018  MERIT Award NIAID
  • 2017  Jurg Tschopp Prize for Cell Death Research

Research Interests

  • Central mechanisms of apoptosis in cancer and the immune system

Selected Publications

Boada-Romero E, Martinez J, Heckmann BL, Green, DR.  The clearance of dead cells by efferocytosis. Nat Rev Mol Cell Biol. 2020 Apr 6. doi: 10.1038/s41580-020-0232-1.

Green DR.  Ghostly metabolic messages from dying cells. Nature, 580, 36-37, 2020.

Green DR. Polyamines and Aging: A CLEAR Connection? Mol Cell 76:5-7, 2019.

Heckmann BL and Green DR. LC3-associated phagocytosis at a glance. J Cell Sci 132, 2019. 

Green DR.  Means to an End:  Apoptosis and Other Cell Death Mechanisms.  Second Edition.  Cold Spring Harbor Press.  2018.  

Green DR.  (editor) Cell death in the immune system.  Immunol. Rev. Vol. 77, 2017.

Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR. ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences. Cell 169(2):286-300.e16, 2017.

Martinez J, Cunha LD, Park S, Yang M, Lu Q, Orchard R, Li QZ, Yan M, Janke L, Guy C, Linkermann A, Virgin HW, Green DR. Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells. Nature 533(7601):115-119, 2016.

Verbist KC, Guy CS, Milasta S, Liedmann S, Kaminski MM, Wang R, Green DR.  Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature 532(7599):389-393, 2016.

Wallach D, Kang TB, Dillon CP, Green DR. Programmed necrosis in inflammation: Toward identification of the effector molecules. Science 352(6281):aaf2154, 2016.

Llambi F, Wang YM, Victor B, Yang M, Schneider DM, Gingras S, Parsons MJ, Zheng JH, Brown SA, Pelletier S, Moldoveanu T, Chen T, Green DR. BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation. Cell 165(2):421-433, 2016.

Quarato G, Guy CS, Grace CR, Llambi F, Nourse A, Rodriguez DA, Wakefield R, Frase S, Moldoveanu T, Green DR. Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. Mol Cell 61(4):589-601, 2016.

Martinez J, Malireddi RK, Lu Q, Cunha LD, Pelletier S, Gingras S, Orchard R, Guan JL, Tan H, Peng J, Kanneganti TD, Virgin HW, Green DR. Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nat Cell Biol 17(7):893-906, 2015.

Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong YN, Janke LJ, Kelliher MA, Kanneganti TD, Green DR. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell 157(5):1189-1202, 2014.

Kim JY, Zhao H, Martinez J, Doggett TA, Kolesnikov AV, Tang PH, Ablonczy Z, Chan CC, Zhou Z, Green DR, Ferguson TA. Noncanonical autophagy promotes the visual cycle. Cell 154(2):365-376, 2013.

Chipuk JE, McStay GP, Bharti A, Kuwana T, Clarke CJ, Siskind LJ, Obeid LM, Green DR. Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell 148(5):988-1000, 2012.

Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell October 25, 2011.

Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green DR. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci U S A October 3, 2011.

Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471(7338):363-7, 2011.

Green DR. Stress in biomedical research: six impossible things. Mol Cell 40(2):176-8, 2010.

Last update: April 2020

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