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Jeffery M. Klco, MD, PhD
Jeffery M. Klco, MD, PhD

Jeffery M. Klco, MD, PhD

Member, St. Jude Faculty

  • Director, Division of Hematopathology and Molecular Pathology



MD, PhD – Washington University School of Medicine, St. Louis, MO
Resident Physician – Barnes-Jewish Hospital/Washington University School of Medicine, St. Louis, MO
Fellow – Barnes-Jewish Hospital/Washington University School of Medicine, St. Louis, MO
BS – Boston College, Boston, MA

Honors & Awards

  • 2022 St Jude Mentor of the Year
  • 2017 V Foundation, Scholar (Pediatric Cancer Research) Grant Recipient
  • 2015 American Society of Clinical Investigation Young Investigator Award
  • 2014-present Burroughs Wellcome Fund, Career Award for Medical Scientists
  • 2013-present NIH/NHLBI Clinical Scientist Career Development Award (K08)
  • 2013-2015 NIH/NCI Loan Repayment Program recipient

Research interests

  • Genomic and functional characterization of acute myeloid leukemia and myelodysplastic syndromes
  • Using experimental in vivo and in vitro approaches to study signaling pathways in myeloid development
  • Using genomic information to improve the outcome and risk stratification of children with cancer

Selected Publications

Umeda M, Ma J, Westover T, Ni Y, Song G, Maciaszek JL, Rusch M, Rahbarinia D, Foy S, Huang BJ, Walsh MP, Kumar P, Liu Y, Yang W, Fan Y, Wu G, Baker S, Ma X, Wang L, Alonzo TA, Rubnitz JE, Pounds S, Klco JM (2024). A new genomic framework to categorize pediatric acute myeloid leukemia.  Nat Genet, 56(2):281-293.  PMID: 38212634.

Nishiguchi G, Mascibroda LG, Young SM, Caine EA, Abdelhamed S, Kooijman JJ, Miller DJ, Das S, McGowan K, Mayasundari A, Shi Z, Barajas JM, Hiltenbrand R, Aggarwal A, Chang Y, Mishra V, Narina S, Thomas M, Loughran AJ, Kalathur R, Yu K, Zhou S, Wang X, High AA, Peng J, Pruett-Miller SM, Daniels DL, Urh M, Shelat AA, Mullighan CG, Riching KM, Zaman GJR, Fischer M, Klco JM*, Rankovic Z (2024). Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nat Commun. 15(1):482. PMID: 38228616. *, Co-corresponding author

Barajas JM, Rasouli M, Umeda M, Hiltenbrand RL, Abdelhamed S, Mohnani R, Arthur B, Westover T, Thomas ME 3rd, Ashtiani M, Janke LJ, Xu B, Chang TC, Rosikiewicz W, Xiong E, Rolle C, Low J, Krishnan R, Song G, Walsh MP, Ma JJ, Rubnitz JE, Iacobucci I, Chen T, Krippner-Heidenreich A, Zwaan CM, Heidenreich O, Klco JM (2024). Acute myeloid leukemias with UBTF tandem duplications are sensitive to Menin inhibitors.  Blood, 143(7):619-630. PMID: 37890156.

Thomas ME 3rd, Qi W, Walsh MP, Ma J, Westover T, Abdelhamed S, Ezzell  LJ, Rolle C, Xiong E, Rosikiewicz W, Xu B, Pruett-Miller SM, Loughran AJ, Janke LJ, Klco JM (2024). Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia. Leukemia, 38(5):991-1002.

Barajas JM, Umeda M, Contreras L, Khanlari M, Westover T, Walsh MP, Xiong E, Yang C, Otero B, Arribas-Layton M, Abdelhamed S, Song G, Ma X, Thomas ME, Ma J, Klco JM (2024). UBTF Tandem Duplications in Pediatric myelodysplastic syndrome and acute myeloid leukemia: implications for clinical screening and diagnosis. Haematologica, in press.

Wong JC, Weinfurtner KM, Westover T, Kim J, Lebish EJ, Alzamora M, Huang BJ, Walsh M, Abdelhamed S, Ma J, Klco JM *, Shannon K (2024). 5G2 Mutant Mice Model Loss of a Commonly Deleted Segment of Chromosome 7q22 in Myeloid Malignancies.  Leukemia, 38(5):1182-1186. *, Co-corresponding author.

Ryland GL, Umeda M, Holmfeldt L, Lehmann S, Herlin MK, Ma J, Khanlari M, Rubnitz JE, Ries RE, Kosasih HJ, Ekert PG, Goh HN, Tiong IS, Grimmond SM, Haferlach C, Day RB, Ley TJ, Meshinchi S, Ma X, Blombery P, and Klco JM (2023). Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.  Blood, 141(7):800-805. 

Liu Y, Klein J, Bajpai R, Dong L, Tran Q, Kolekar P, Smith JL, Ries RE, Huang BJ, Wang YC, Alonzo TA, Tian L, Mulder HL, Shaw TI, Ma J, Walsh MP, Song G, Westover T, Autry RJ, Gout AM, Wheeler DA, Wan S, Wu G, Yang JJ, Evans WE, Loh M, Easton J, Zhang J, Klco JM*, Meshinchi S*, Brown PA*, Pruett-Miller SM*, Ma X* (2023). Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication. Nat Commun, 14(1):1739. *, Co-corresponding author

Abdelhamed S, Thomas ME III, Westover T, Umeda M, Xiong E, Rolle C, Walsh MP, Wu H, Schwartz JR, Valentine V, Valentine M, Pounds S, Ma J, Janke LJ and Klco JM (2022).  Mutant Samd9l expression impairs hematopoiesis and induces bone marrow failure in mice.  J Clin Invest, 132(21):e158869.

Umeda M, Ma J, Huang B, Hagiwara K, Westover T, Abdelhamed S, Barajas JB, Thomas ME III, Walsh MP, Song G, Tian L, Liu Y, Chen X, Kolekar P, Tran Q, Foy S, Maciaszek JL, Kleist AB, Leonti A, Ju B, Easton J, Wu H, Valentine V,  Valentine M, Liu Y, Ries RE, Smith J, Parganas E, Iacobucci I, Hiltenbrand R, Miller J , Myers J, Rampersaud E, Rahbarinia D, Rusch M, Wu G, Inaba H, Wang Y, Alonzo TA, Downing JR, Mullighan CG, Pounds S , Babu MM, Zhang J, Rubnitz JE, Meshinchi S, Ma X, and Klco JM (2022). Integrated genomic analysis identifies UBTF tandem duplications as a recurrent lesion in pediatric acute myeloid leukemia. Blood Cancer Discov. 3(3):194-207.

Last update: July 2024