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Andrew Jackson Murphy, MD
Andrew Jackson Murphy, MD

Andrew Jackson Murphy, MD

Associate Member, St. Jude Faculty

  • Chief, General Pediatric Surgery Division



MD - Emory University School of Medicine Atlanta, Georgia
Residency (General Surgery) - Vanderbilt University Medical Center Nashville, Tennessee
Fellowship (Pediatric Surgery) - Boston Children’s Hospital Boston, Massachusetts

Research Interests

  • Pediatric Surgical Oncology
  • Unfavorable histology and treatment-resistant Wilms tumor
  • Wilms tumorigenesis
  • Cancer stem cells

Selected Publications

VanHouwelingen LT, Veras LV, Lu JM, Wynn L, Wu J, Prajapati HJ, Gold RE, Murphy AJ, Fernandez-Pineda l, Gosain A, Pui CH, Davidoff AM. Neutropenia at the time of subcutaneous port insertion may not be a risk factor for early infectious compiications in pediatric oncology patients. J Pediatr Surg 2019 149. doi: 10.1016/j.jpedsurg.2018.10.024. Epub 2018 Oct 5. PMID: 30661598

Fernandez-Pineda l, Seims A, VanHouwelingen L, Abdelhafeez H, Wu H, Wu J, Murphy AJ, Davidoff AM. Modified uniportal video-assisted thoracic surgeot versus three-port approach for lung nodule biopsy in pediatric cancer patients. J Laparoendosc Adv Surg Tech A Nov 10, 2018. doi: 10.1089/1ap.2018.0120. [Epub ahead of print] PMID:30418096

Anghelescu DL, Brown CL, Murphy AJ, Davidoff AM, Dickson PVs Glazer ES, Stiles ZE, Bishop MW, Douthitt L, Deneve JL. Anesthesia and pain management for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for desmoplastic small round cell tumors in children, adolescents, and young adults. Ann Surg Oncol 2018 Oct 23. doi: 10.1245/s10434-018-6808-8. [Epub ahead of print] PMID:30353396

Madenci AL, Weil BR, Liu Q, Murphy AJ, Gibson TM, Yasui Y, Leisenring WM, Howell RM, Tinkle CL, Nekhlyudov L, Diller LR, Armstrong GT, Oeffinger KC, Weldon CB. Long-term risk of venous thromboembolism in survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol Sep 14:JC02018784595, 2018. doi: 10.1200/JCO.2018.78.4595. [Epub ahead of print]

Stiles ZE, Dickson P V, Glazer ES, Murphy AJ, Davidoff AM, Behrman SW, Bishop MW, Martin MG, Deneve JL. Desmoplastic small round cell tumor: A nationwide study of a rare sarcoma. J Surg Oncol Jun 7, 2018. doi: 10.1002/jso.25071. [Epub ahead of print] PMID:29878371

Murphy AJ, Davidoff AM. Bilateral Wilms tumor: a surgical perspective. Children (Basel). 2018 Sep 24;5(10). pii: El 34. doi: 10.3390/children5100134. Review. First author, corresponding author

El-Gohary Y, Abdelhafeez A, Paton E, Gosain, A, Murphy AJ. Pyloric stenosis: an enigma more than a century after the first successful treatment. Pediatr Surg Int Oct 13, 2017. doi: 10.1007/s00383-017-4196-y. [Epub ahead of print] Review. PMiD:29030700. Senior author, corresponding author

Onwubiko C, Bairdain S, Murphy AJ, McSweeney ME, Perkins J, Rathod RH, Baird C, Smithers CJ. Laparoscopic Gastrojejunostomy placement in infants with congenital cardiac disease. J Laparoenosc Adv Surg Tech A Dec;25(12):1047-50, 2015. doi: 10.1089/lap.2015.0118. Epub 2015 Sep 24.PMID: 26402465

Murphy AJ, Pierce J, Seeley EH, Sullivan LM, Ruchelli ED, Nance ML, Caprioli RM, Lovvorn HN 3rd. Peptide spectra in Wilms tumor that associate with adverse outcomes. J Surg Res  Jun 15;196(2):332-8, 2015. doi: 10.1016/j.jss.2015.03.020. Epub 2015 Mar 18.PMID:25868780

Pierce J, Murphy AJ, Panzer A, de Caestecker C, Ayers GD, Neblett D, Saito-Diaz K, de Caestecker MP, Lovvorn HN 3rd. SIX2 effects on Wilms tumor biology. Transl Oncol Dec;7(6):800-11, 2014. doi: 10.1016/j.tranon.2014.09.005. Cited in PubMed; PMID: 25500091

Murphy AJ, Pierce J, de Caestecker C, Libes JM, Neblett DW, de Caestecker MP, Perantoni AO, Tanigawa S, Anderson JR, Dome JS, Das A, Carroll TJ, Lovvorn HN 3rd. Aberrant activation, nuclear localization, and phosphorylation of Yes-associated protein-1 in the embryonic kidney and Wilms tumor. Pediatr Blood Cancer Feb;61(2):198-205, 2014. doi: 10.1002/pbc.24788. Epub 2013 Sep 20. PMID: 24115727

Murphy AJ, Pierce J, de Caestecker C, Ayers GD, Zhao A, Krebs JR, Kenyi Saito-Diaz V, Lee E, Perantoni AO, de Caestecker MP, Lovvorn HN 3rd. CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus. Oncotarget Jan;5(2):386-402, 2014.PMID: 24481423

Murphy AJ, Ayers GD, Hilmes MA, Mukherjee K, Wilson KJ, Allen WM, Fernandez-Pineda I, Shinall MC, Zhao Z, Furman WL, McCarville MB, Davidoff AM, Lovvorn HN 3rd. Imaging analysis of hepatoblastoma resectability across neoadjuvant chemotherapy. J Pediatr Surg Jun;48(6):1239-48, 2013. doi: 10.1016/j.jpedsurg.2013.03.019; PMID: 23845613

Murphy AJ, de Caestecker C, Pierce J, Boyle SC, Ayers GD, Zhao Z, Libes JM, Correa, H, Walter T, Huppert SS, Perantoni AO, de Caestecker MP, Lovvorn HN 3rd. CITED1 expression in liver development and hepatoblastoma. Neoplasia Dec; 14(12):1153-63, 2012. PMID: 23308048

Murphy AJ, Rauth TP, Lovvorn HN 3rd. Chronic biloma after right hepatectomy for stage IV hepatoblastoma managed with roux-en-Y biliary cyst enterostomy. J Pediatr Surg Nov;47(11):e5-9, 2012. doi: 10.1016/j.jpedsurg.2012.06.007; PMID: 23164033

Murphy AJ, Axt JR, Lovvorn HN 3rd. Associations between pediatric choledochal cysts, biliary atresia, and congenital cardiac anomalies. Journal of Surgical Research Oct;177(2):e59-63, 2012. Cited in PubMed; PMID: 22572617.

Murphy AJ*, Axt JR*, de Caestecker C, Pierce J, Correa H, Seeley EH, Caprioli RM, Newton MW, de Caestecker MP, Lovvorn HN 3rd. Molecular characterization of Wilms' tumor from a resource-constrained region of sub-Saharan Africa. International Journal of Cancer Sep;131(6):E983-94, 2012. Cited in PubMed; PMID: 22437966.

Axt JR, Murphy AJ, Arbogast PG, Lovvorn HN 3rd. Volume-outcome effects for children undergoing resection of renal malignancies. Journal of Surgical Research Sep;177(1):e27-33, 2012. Cited in PubMed; PMID: 22541281.

Murphy AJ, Pierce J, de Caestecker C, Taylor C, Anderson JR, Perantoni AO, de Caestecker MP, Lovvorn HN 3rd. SIX2 and CITED1, markers of nephronic progenitor self-renewal remain active in primitive elements of Wilms' tumor. Journal of Pediatric Surgery. 2012 Jun; 47(6): 1239-1249. Cited in PubMed; PMID: 22703800.

Murphy AJ, Axt JR, Crapp SJ, Martin CA, Crane GL, Lovvorn HN 3rd. Concordance of imaging modalities and cost minimization in the diagnosis of pediatric choledochal cysts. Pediatric Surgery International Jun;28(6):615-621, 2012. Cited in PubMed; PMID: 22526551.

Murphy AJ, Li Y, Pietsch JB, Chiang C, Lovvorn HN 3rd. Mutational analysis of NOG in esophageal atresia and tracheoesophageal fistula patients. Pediatric Surgery International Apr;28(4):335-340, 2012. Cited in PubMed; PMID: 22083168.

Axt J*, Murphy AJ*, Seeley EH, Martin CA, Taylor C, Pierce J, Caprioli RM, Whiteside M, Lovvorn HN 3rd. Race disparities in Wilms tumor incidence and biology. Journal of Surgical Research Sep;170(1):112-119, 2011. Cited in PubMed; PMID: 21529835. *shared first authorship (equal contribution to work)

Last update: February 2019