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Swati Naik, MBBS
Swati Naik, MBBS

Swati Naik, MBBS

Associate Member, St. Jude Faculty



MBBS – Deccan College of Medical Sciences, Hyderabad, India
Pediatric Residency - SUNY Downstate Medical Center, Brooklyn, New York
Pediatric Hematology and Oncology Fellowship - Baylor College of Medicine, Houston, Texas
Hematopoietic Stem Cell Transplant Fellowship - Baylor College of Medicine, Houston, Texas                                 

Research Interests

  • Cellular therapies for hematological malignancies
  • Graft manipulation and incorporation of cellular therapies in transplant platform to maximize graft-versus-leukemia effect and minimize infections
  • Haplo-identical transplants for high-risk hematological malignancies

Selected Publications

Ruderfer D, Wu M, Wang T, Srivaths PR, Krance RA, Naik S, Bocchini CE. BK Virus Epidemiology, Risk Factors, and Clinical Outcomes: An Analysis of Hematopoietic Stem Cell Transplant Patients at Texas Children's Hospital. Pediatric Infect Dis Soc Jan 8:piaa147, 2021. doi: 10.1093/jpids/piaa147. Online ahead of print. PMID: 33416086

Lulla S, Naik S, Vasileiou S, Tzannou I, Watanabe A, Kuvalekar M, Lulla S, Carrum G, Ramos CA, Kamble R, Tao w, Wu MF, Robertson C, Gee A, Chung BM,  B, Brenner MK, Heslop H,  Vera J, Leen A. Clinical effects of administering leukemia-specific donor T cells to patients with AML/MDS post-allogeneic transplant. Blood Dec 3;blood.2020009471, 2020. doi: 10.1182/blood.2020009471. Online ahead of print. PMID: 33270816

Naik S, Eckstein O, Sasa G, Forbes L, Krance RA, Heslop HE, Allen CE, Martinez CA. Incorporation of Thiotepa to conditioning regimen to improve engraftment for patients with Hemophagocytic Lymphohistiocytosis. Br J Haematol Mar;188(6):e84-e87, 2020. doi: 10.1111/bjh.16370

Naik S, Vasileiou S, Aguayo-Hiraldo P, Kuvalekar M, Sasa GS, Martinez CA, Krance RA, Gottschalk SM, Leen AM. Towards Functional Immune Monitoring in allogeneic transplant recipients. Biol Blood Marrow Transplant May;26(5):911-919, 2020. doi: 10.1016/j.bbmt.2020.01.005

Lapteva N, Gilbert M, Diaconu I, Rollins LA, Al-Sabbagh M, Naik S, Krance RA, Tripic T, Hiregange M, Raghavan D, Dakhova O, Rouce RH, Liu H, Omer B, Savoldo B, Dotti G, Cruz CR, Sharpe K, Gates M, Orozco A, Durett A, Pacheco E, Gee AP, Ramos CA, Heslop HE, Brenner MK, Rooney CM. T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor-Expressing T Cells. Clin Cancer Res Dec 15;25(24):7340-7350, 2019. doi: 10.1158/1078-0432.CCR-18-3199. Epub 2019 Sep 26.

Naik S, Martinez CA, Omer B, Sasa G, Yassine K, Allen CE,  Kamdar K, Orth R, Wu MF,  Leung K,  Gottschalk S, Brenner MK, Heslop HE,  Krance RA. Allogeneic hematopoietic stem cell transplant for relapsed and refractory Non-Hodgkin Lymphoma in pediatric patients. Blood Adv Sep 24;3(18):2689-2695, 2019. doi: 10.1182/bloodadvances.2018026203

Tzannou I, Watanabe A, Naik S, Daum R, Kuvalekar M, Leung KS, Martinez C, Sasa G, Wu M, Gee AP, Krance RA, Gottschalk S, Heslop HE, Omer B. "Mini" bank of only 8 donors supplies CMV-directed T cells to diverse recipients. Blood Adv Sep 10;3(17):2571-2580, 2019. doi: 10.1182/bloodadvances.2019000371

Vasileiou S, Turney AM, Kuvalekar M, Mukhi S, Watanabe A, Lulla P, Ramos CA, Naik S, Vera JF, Tzannou I, Leen AM. Rapid generation of multivirus-specific T lymphocytes for the prevention and treatment of respiratory viral infections. Haematologica Jan;105(1):235-243, 2020. doi: 10.3324/haematol.2018.206896. Epub Apr 19, 2019.

Castillo P, Voigt K, Crockett C, Stout JT, Krance R, Naik S. Purtscher-like retinopathy: A rare presentation of hematopoietic stem cell transplant-associated thrombotic microangiopathy. Pediatr Transplant Jan 20:e13344, 2019. doi: 10.1111/petr.13344

Arasaratnam RJ, Tzannou I, Gray T, Aguayo-Hiraldo PI, Kuvalekar M, Naik S, Gaikwad A, Liu H, Miloh T, Vera JF, Himes RW, Munoz FM, Leen AM. Dynamics of virus-specific T cell immunity in pediatric liver transplant recipients. Am J Transplant Sep;18(9):2238-2249, 2018. doi: 10.1111/ajt.14967. Epub Jul 10, 2018.

John TD, Naik S, Leung K, Sasa G, Martinez C, Krance RA. Allogeneic hematopoietic cell transplant following crizotinib monotherapy for relapsed/refractory anaplastic large cell lymphoma. Pediatr Transplant Aug;22(5):e13210, 2018. doi: 10.1111/petr.13210. Epub 2018 May 2, 2018.

Yanir AD, Hanson IC, Shearer WT, Noroski LM, Forbes LR, Seeborg FO, Nicholas S, Chinn I, Orange JS, Rider NL, Leung KS, Naik S, Carrum G, Sasa G, Hegde M, Omer BA, Ahmed N, Allen CE, Khaled Y, Wu MF, Liu H, Gottschalk SM, Heslop HE, Brenner MK, Krance RA, Martinez CA. High Incidence of Autoimmune Disease Post HSCT for Chronic Granulomatous Disease. Biol Blood Marrow Transplant Aug;24(8):1643-1650, 2018. doi: 10.1016/j.bbmt.2018.03.029

Yanir AD, Martinez CA, Sasa G, Leung K, Gottschalk S, Omer B, Ahmed N, Hegde M, Eunji J, Liu H, Heslop HE, Brenner MK, Krance RA, Naik S. Current Allogeneic Hematopoietic Stem Cell Transplantation for Pediatric Acute Lymphocytic Leukemia: Success, Failure and Future Perspectives-A Single-Center Experience, 2008 to 2016. Biol Blood Marrow Transplant Jul;24(7):1424-1431, 2018. doi: 10.1016/j.bbmt.2018.03.001

Ngwube A, Hanson IC, Orange J, Rider NL, Seeborg F, Shearer W, Noroski L, Nicholas S, Forbes L, Leung K, Sasa G, Naik S, Hegde M, Omer B, Ahmed N, Allen C, Gottschalk S, Wu MF, Liu H, Brenner M, Heslop H, Krance R, Martinez C. Outcomes after Allogeneic Transplant in Patients with Wiskott-Aldrich Syndrome. Biol Blood Marrow Transplant Nov 28, 2017. pii: S1083-8791(17)30865-0. doi: 10.1016/j.bbmt.2017.11.019

Tzannou I, Papadopoulou A, Naik, S, Leung K, Martinez C, Ramos CA, Carrum G, Sasa G, Lulla P, Watanabe A, Kuvalekar M, Gee AP, Wu J, Liu H, Grilley B, Krance R, Gottschalk S, Brenner M, Rooney C, Heslop H, Leen A, Omer B. Off the Shelf Virus-specific T cells to Treat BK virus, HHV-6, CMV, EBV and Adenovirus Infections after Allogeneic Hematopoietic Stem Cell Transplantation. J Clin Oncol Nov 1;35(31):3547-3557, 2017. doi: 10.1200/JCO.2017.73.0655. Epub Aug 7, 2017.

Aguayo-Hiraldo PI, Arasaratnam RJ, Tzannou I, Kuvalekar M, Lulla P, Naik S, Martinez CA, Piedra PA, Vera JF, Leen AM. Characterizing the cellular immune response to parainfluenza virus 3. J Infect Dis May 2, 2017.

Au JK, Graziano C, Elizondo RA, Roth DR, Koh CJ, Gonzales ET, Tu DT, Janzen N, Naik S, Seth A. Urologic Outcomes of Children with Hemorrhagic Cystitis after Bone Marrow Transplant at a Single Institution. Urology Mar;101:126-132, 2017.

Naik S, Nicholas S, Keller M. Adoptive Immunotherapy for Primary Immunodeficiency Disorders with Virus-Specific Cytotoxic T-lymphocytes. J Allergy Clin Immunol May;137(5):1498-1505, 2016.

Zhou X, Naik S, Dakhova O, Dotti G, Heslop H, Breen M. Serial activation of the inducible caspase 9 safety switch after human stem cell transplantation. Mol Ther Apr;24(4):823-31, 2016.

Naik S, Heslop H. Engineering haplo-identical transplants. Bone Marrow Transplant Jul;50(7):884-5, 2015.

Naik S, Martinez C, Leung K, Gottschalk S, Ahmed N, Allen C, Heslop H, Brenner M, Krance R. Outcomes after second allogeneic transplants in pediatric patients with relapsed hematological malignancies. Biol Blood Marrow Transplant Jul;21(7):1266-7, 2015.

Zhou X, Dotti G, Krance R, Martinez C, Naik S, Kamble R, Durett A, Dakhova O, Savoldo B, Di Stasi A, Spencer D, Lin Y, Liu H, Grilley B, Gee A, Rooney C, Heslop H, Brenner M. Inducible Caspase-9 Suicide Gene Controls Adverse Effects from Alloreplete T Cells after Haploidentical Stem Cell Transplantation. Blood Jun 25;125(26):4103-13, 2015.

Bavare AC, Naik S, Lin PH, Poi MJ, Yee DL, Bronicki RA, Philip JX, Desai MS. Catheter-directed Thrombolysis for Severe Pulmonary Embolism in Pediatric Patients. Ann Vasc Surg Epub ahead of print Mar 31, 2014.

Naik S, Teruya J, Dietrich J, Venkateswaran L. Utility of platelet function analyzer as a screening tool for the diagnosis of Von Willebrand disease in adolescents with menorrhagia. Pediatr Blood Cancer Jul;60(7):1184-7, 2013.

Naik S, Mahoney D. Successful Treatment of Congenital TTP With a Novel Approach Using Plasma-derived Factor VIII. J Pediatr Hematol Oncol Oct;35(7):551-3, 2013.

Chow KKH, Naik S, Kakarla S, Brawley VS, Shaffer DR, Yi Z, Rainusso N, Wu M, Liu H, Kew Y, Grossman R, Powell S, Lee D, Ahmed N, Gottschalk S. T cells redirected to EphA2 for the Immunotherapy of Glioblastoma. Mol Ther Mar;21(3):629-37, 2013. doi: 10.1038/mt.2012.210. Epub 2012 Oct 16.

Viswakarma N, Naik S, Reddy JK. Transcriptional regulation of mitochondrial cell death-inducing DNA fragmentation factor-like effector A (Cidea) in mouse liver by PPAR alpha and PPAR gamma. Journal of Biological Chemistry 25(2):18613-18624, 2007. 

Last update: April 2021