Stacey K. Ogden, PhD
Stacey K. Ogden, PhD

Stacey K. Ogden, PhD

Assistant Member, St. Jude Faculty



PhD – University of Cincinnati College of Medicine, Cincinnati, Ohio (2002)
BA – Miami University, Oxford, Ohio (1997)

Research Interests

  • Mechanisms of Hedgehog signal transduction
  • Identification of factors functioning downstream of the Hedgehog receptor
  • Alteration of Hedgehog signaling in cancer 

Selected Publications

Ogden SK. Genetic evidence for a Smoothened-Gai signaling axis in mammals. Sci Signal 8:fs16, 2015.

Arensdorf AM, Marada S, Ogden SK. Regulation of Smoothened: A Tale of Two Signals. Trends Pharmacol Sci 2015 (in press).

Marada S, Truong A, Ogden SK. The monomeric GTPase Rap1 is a modulator of Hedgehog signaling. Dev Biol 2015 (in press).

Marada S, Navarro G, Truong A, Nachtergaele S, Angelats E, Arensdorf AM, Stewart DP, Rohatgi R, McCormick PJ,  Ogden SK. Functional divergence in the role of N-linked glycosylation in Smoothened signaling. PLoS Genet 11(8):e1005473, 2015.

Rana R, Carroll CE, Lee H-J, Ba, J, Marada S, Grace CRR, Guibao C, Ogden SK, Zheng J. Structural Insights into the Role of the Smoothened Cysteine Rich Domain in Hedgehog Signaling. Nat Commun 4:2965, 2013.

Marada S, Stewart DP, Bodeen WJ, Han Y, Ogden SK. (2013). The Unfolded Protein Response Selectively Targets Active Smoothened Mutants. Mol Cell Biol 33:2375-2387, 2013. *Cover article. [Commentary in Mol Cell Biol 33:2372-4, 2013.]

Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, Chen SC, Su X, Ogden SK, Dang J, Wu G, Gupta V, Andersson AK, Pounds S, Shi L, Easton J, Barbato MI, Mulder HL, Manne J, Wang J, Rusch M, Ranade S, Ganti R, Parker M, Ma J, Radtke I, Ding L, Cazzaniga G, Biondi A, Kornblau SM, Ravandi F, Kantarjian H, Nimer SD, Dohner K, Dohner H, Ley TJ, Ballerini P, Shurtleff S, Tomizawa D, Adachi S, Hayashi Y, Tawa A, Shih LY, Liang DC, Rubnitz JE, Pui CH, Mardis ER, Wilson RK, Downing JR. An inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell 22(5):683-97, 2012.

Carroll CE, Marada S, Stewart DP, Ouyang JX, Ogden SK. The extracellular loops of Smoothened play regulatory roles in control of Hedgehog signal transduction. Development 139:612-621, 2012. *Cover article.

Robbins DJ, Ogden SK. Smoothened signaling through a G-protein effector network. Hedgehog signaling activation in human cancer and its clinical implications. Springer Science and Business Media, Inc. 33-47, 2011. 

Farzan SF, Ogden SK, Robbins DJ. Quantitative insight into models of Hedgehog signal transduction. Fly 4(2):141-4, 2010.

Farzan FS, Stegman MA, Ogden SK, Ascano M, Black KE, Tacchelly O. and Robbins DJ. A quantification of pathway components supports a novel model of Hedgehog signal transduction. J Biol Chem 284(42):28874-84, 2009.

Ogden SK, Fei LF, Schilling NS, Ahmed YF, Hwa J, Robbins DJ. G protein Gαi functions immediately downstream of Smoothened in Hedgehog signaling. Nature 456:967-70, 2008.

Farzan SF, Ascano M Jr., Ogden SK, Sanial M, Plessis A, Robbins DJ. Costal2 functions as a microtubule-dependent motor in the Hedgehog signal transduction pathway. Curr Bio 18:1215-20, 2008. 

Casso DJ, Liu S, Iwaki DD, Ogden SK, Kornberg TB. A screen for modifiers of Hedgehog signaling in Drosophila identifies swm and mts. Genetics 178:1399-1413, 2008.

Yuan Z, Goetz JA, Singh S, Ogden SK, Petty WJ, Dmitorvsky E, Robbins DJ. Frequent requirement of Hedgehog signaling in non-small cell lung carcinoma. Oncogene 26(7):1046-55, 2007.

Ogden SK, Casso DC, Ascano M, Yore MM, Kornberg TB, Robbins DJ. Smoothened regulates activator and repressor functions of Hedgehog signaling through two distinct mechanisms. J Biol Chem 281(11):7237-43, 2006.

Ogden SK, Ascano M, Stegman MA, Robbins DJ. Regulation of Hedgehog signaling: A complex story. Biochem Pharm 67(5):805-14, 2004.

Stegman MA, Goetz JA, Ascano M Jr, Ogden SK, Nybakken KE, Robbins DJ. The Kinesin related protein Costal2 associates with membranes in a Hedgehog sensitive, Smoothened independent manner. J Biol Chem 279(8):7064-71, 2004.

Ogden SK, Ascano M, Stegman MA, Suber LM, Hooper JE, Robbins DJ. Identification of a functional interaction between the transmembrane protein Smoothened and the Kinesin related protein Costal2. Curr Bio 13:1998-2003, 2003.

Last update: October 2015

Full list of publications