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Brent A. Orr, MD, PhD
Brent A. Orr, MD, PhD

Brent A. Orr, MD, PhD

Member, St. Jude Faculty

  • Medical Director, Anatomic Pathology



BS – University of Illinois at Urbana-Champaign, Illinois
PhD – University of Illinois at Urbana-Champaign, Illinois
MD – University of Illinois College of Medicine, Urbana, Illinois
Residency (Anatomic Pathology)  – The Johns Hopkins Hospital, Baltimore, MD
Fellowship (Neuropathology) – The Johns Hopkins Hospital, Baltimore, MD

Honors & Awards

  • 2011 Young Investigator Award for Excellence in Translational Research, Johns Hopkins Department of Pathology
  • 2007 Donald R. Thrush Award for Excellence in Pathology, University of Illinois College of Medicine

Research Interests

  • Identification of molecular biomarkers of prognostic and therapeutic significance to pediatric brain tumors
  • Translation of integrated morphologic and molecular tumor subtyping into clinical neuropathology

Selected Publications

Tse BC, Kaste SC, Brennan R, Orr B, Wilson MW. Enophthalmos and Choroidal Atrophy after Intraophthalmic Artery Chemotherapy for Retinoblastoma. Ophthalmology Oct 22, 2014.

Odia Y, Orr BA, Bell WR, Eberhart CG, Rodriguez FJ. cMYC expression in infiltrating gliomas: associations with IDH1 mutations, clinicopathologic features and outcome. J Neurooncol 115(2):249-259, 2013.

Lim KS, Lim KJ, Price AC, Orr BA, Eberhart CG, Bar EE. Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner. Oncogene Sept 30, 2013.

Chu Q, Orr BA, Semenkow S, Bar EE, Eberhart CG. Prolonged inhibition of glioblastoma xenograft initiation and clonogenic growth following in vivo Notch blockade. Clin Cancer Res 19(12):3224-3233, 2013.

Nguyen DN, Heaphy CM, de Wilde RF, Orr BA, Odia Y, Eberhart CG, Meeker AK, Rodriguez FJ. Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas. Brain Pathol 23(3):237-243, 2013.

Orr BA, Haffner MC, Nelson WG, Yegnasubramanian S, Eberhart CG. Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. Plos One 7(7):e41036, 2012.

Xuewei X, Murugappan R, Orr BA, Reh, D, Gallia GL. Expanded endonasal endoscopic approach for resection of a pituitary macroadenoma coexistent with a cavernous carotid artery aneurysm. J Clin Neursosci Epub 2012/07/25. doi: 10.1016/j.jocn.2011.11.032.

Kahlert UD, Maciaczyk D, Doostkam S, Orr BA, Simons B, Bogiel T, Reithmeier T, Prinz M, Schubert J, Niedermann G, Brabletz T, Eberhart CG, Nikkhah G, Maciaczyk J. Activation of canonical WNT/beta-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition. Cancer Letters June 2, 2012. Epub ahead of print. doi: 10.1016/j.canlet.2012.05.024.

Baia GS, Caballero OL, Orr BA, Lal A, Ho JS, Cowdrey C, Tihan T, Mawrin C, Riggins GJ. Yes-Associated Protein 1 Is Activated and Functions as an Oncogene in Meningiomas. Molecular Cancer Research May 24, 2012. Epub ahead of print. doi: 10.1158/1541-7786.

Orr BA, Eberhart CG. Nature versus nurture in glioblastoma: microenvironment and genetics can both drive mesenchymal transcriptional signature. The American Journal of Pathology 180(5):1768-71, 2012.

Zuniga MG, Orr BA, Chang SS, Tufano RP. Suboccipital malignant solitary fibrous tumor: report of a case. Ear, Nose, & Throat Journal 91(2):E25-7, 2012.

Rodriguez FJ, Orr BA, Ligon KL, Eberhart CG. Neoplastic cells are a rare component in human glioblastoma microvasculature. Oncotarget 3(1):98-106, 2012.

Siu IM, Salmasi V, Orr BA, Zhao Q, Binder ZA, Tran C, Ishii M, Riggins GJ, Hann CL, Gallia GL. Establishment and characterization of a primary human chordoma xenograft model. Journal of Neurosurgery 2012;116(4):801-9, 2012.

Mehta VA, Kretzer RM, Orr B, Jallo GI. Primary intramedullary spinal germ cell tumors. World Neurosurgery 76(5):478 e1-6, 2011.

Orr BA, Bai H, Odia Y, Jain D, Anders RA, Eberhart CG. Yes-associated protein 1 is widely expressed in human brain tumors and promotes glioblastoma growth. Journal of Neuropathology and Experimental Neurology 70(7):568-77, 2011.

Li J, Recinos PF, Orr BA, Burger PC, Jallo GI, Recinos VR. Papillary tumor of the pineal region in a 15-month-old boy. Journal of Neurosurgery Pediatrics 7(5):534-8, 2011.

Jiang X, Orr BA, Kranz DM, Shapiro DJ. Estrogen induction of the granzyme B inhibitor, proteinase inhibitor 9, protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells. Endocrinology 147(3):1419-26, 2006.

Schelman WR, Andres R, Ferguson P, Orr B, Kang E, Weyhenmeyer JA. Angiotensin II attenuates NMDA receptor-mediated neuronal cell death and prevents the associated reduction in Bcl-2 expression. Brain Research Molecular Brain Research 128(1):20-9, 2004.

Peng KW, Holler PD, Orr BA, Kranz DM, Russell SJ. Targeting virus entry and membrane fusion through specific peptide/MHC complexes using a high-affinity T-cell receptor. Gene Therapy 11(15):1234-9, 2004.

Orr BA, Carr LM, Wittrup KD, Roy EJ, Kranz DM. Rapid method for measuring ScFv thermal stability by yeast surface display. Biotechnology Progress 19(2):631-8, 2003.

Roy EJ, Gawlick U, Orr BA, Kranz DM. Folate-mediated targeting of T cells to tumors. Advanced Drug Delivery Reviews 56(8):1219-31, 2004.

Roth ME, Feng L, McConnell KJ, Schaffer PJ, Guerra CE, Affourtit JP, Piper KR, Guccione L, Hariharan J, Ford MJ, Powell SW, Krishnaswamy H, Lane J, Intrieri G, Merkel JS, Perbost C, Valerio A, Zolla B, Graham CD, Hnath J, Michaelson C, Wang R, Ying B, Halling C, Parman CE, Raha D, Orr B, Jedrzkiewicz B, Liao J, Tevelev A, Mattessich MJ, Kranz DM, Lacey M, Kaufman JC, Kim J, Latimer DR, Lizardi PM. Expression profiling using a hexamer-based universal microarray. Nature Biotechnology 22(4):418-26, 2004.

Roy EJ, Gawlick U, Orr BA, Rund LA, Webb AG, Kranz DM. IL-12 treatment of endogenously arising murine brain tumors. Journal of Immunology 165(12):7293-9, 2000.

Last update: January 2015