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Stan Pounds, PhD
Stan Pounds, PhD

Stan Pounds, PhD

Member, St. Jude Faculty

  • Director of Biostatistics Courses, St. Jude Graduate School of Biomedical Sciences

Departments

Education

BS – Harding University, Searcy, Arkansas (1997)
PhD – Texas A&M University, College Station, Texas (2002)

Research Interests

I develop statistical methods for various problems that arise in cancer genomics research.  Currently, my primary interests are in developing methods to integrate multiple pharmacologic and clinical endpoints with multiple forms of genomic data.  I am also interested in developing methods to identify genomic alterations that are biologically and clinically relevant.

Selected Publications

Fornerod M, Ma J, Noort S, Walsh MP, Shi L, Nance S, Liu Y, Wang Y, Song G, Lamprecht T, Easton J, Mulder HL, Yergeau D, Myers J, Kamens JL, Obeng EA, Pigazzi M, Jarosova M, Kelaidi C, Polychronopoulou S, Lamba JK, Baker SD, Rubnitz JE, Reinhardt D, an den Heuvel-Eibrink MM, Locatelli F, Hasle H, Klco JM, Downing JR, Zhang J, Pounds S, Zwaan CM, Gruber, TA.  Integrative genomic analysis of pediatric myeloid-related acute leukemias identifies novel subtypes and prognostic indicators. Blood Cancer Discovery October 6, 2021. 

Nguyen NHK, Wu H, Tan H, Peng J, Rubnitz JE, Cao X, Pounds S, Lamba JK. Global Proteomic Profiling of Pediatric AML: A Pilot Study. Cancers (Basel) Jun 24;13(13):3161, 2021.

Stockard B, Bhise N, Shin M, Guingab-Cagmat J, Garrett TJ, Pounds S, Lamba JK. Cellular Metabolomics Profiles Associated With Drug Chemosensitivity in AML. Front Oncol Jun 10;11:678008, 2021.

Cao X, Pounds SB. Gene-Set Distance Analysis (GSDA):  A Powerful Tool for Gene-Set Association Analysis. BMC Bioinformatics 22:207, 2021.

Davis EM, Sun Y, Liu Y, Kolekar P, Shao Y, Szlachta K, Mulder HL, Ren D, Rice SV, Wang Z, Nkitandwe J, Gout AM, Shaner B, Hall S, Robison LL, Pounds S, Klco JM, Easton J, and Ma X.  SequencErr: measuring and suppressing errors in next-generation sequencing data.  Genome Biology 22:37, 2021.

Klco J, Schwartz J, Ma J, Kamens J, Westover T, Walsh M, Brady S, Michael J, Chen X, Song G, Wu G, Wu H, Branstetter C, Hiltenbrand R, Walsh M, Nichols K, Maciaszek J, Liu Y, Kumar P, Easton J, Newman S, Rubnitz J, Mullighan C, Pounds S, Zhang J, Gruber T, Ma X, and Montefiori L. The Acquisition of Molecular Drivers in Pediatric Therapy-Related Myeloid Neoplasms.  Nature Communications Feb 12;12(1):985, 2021..

Lamba JK, Cao X, Raimondi S, Downing J, Ribeiro R, Gruber TA, Rubnitz J, Pounds S. DNA Methylation Clusters and their Relation to Cytogenetic Features in Pediatric AML. Cancers (Basel) 12(10):3024, 2020.

Autry RJ, Paugh SW, Carter R, Shi L, Liu J, Ferguson DC, Lau CE, Bonten EJ, Yang W, McCorkle JR, Beard JA, Panetta JC, Diedrich JD, Crews KR, Pei D, Coke CJ, Natarajan S, Alireza Khatmian, Karol SE, Lopez-Lopez E, Diouf B, Smith C, Gocho Y, Hagiwara K, Roberts KG, Pounds S, Kornblau SM, Stock W, Paietaa EM, Litzow MR, Inaba H, Mullighan CG, Jeha S, Pui C-H, Cheng C, Savic D, Yu J, Gawad C, Relling MV, Yang JJ, Evans WE.  Integrative genomic analyses reveal known and novel mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia.  Nature Cancer Mar; 1(3):329-344, 2020.

Murphy A, Chen X, Pinto EM, Williams JS, Clay MR, Pounds SB, Cao X, Shi L, Neale G, Morton CL, Wollard MA, Mulder HL, Gil HJ, Rehg JE, Billups CA, Harlow ML, Dome JS, Houghton PJ, Easton J, Zhang J, George RE, Zambetti GP, Davidoff AM.  Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor.  Nature Communications Dec 20;10(1):5806, 2019.

Alexander TB, Gu Z, Choi JK, Iacobucci I, Dickerson K, Loh ML, Horan J, Buldini B, Basso G, Elitzur S, de Haas V, Zwaan CM, Yeoh A, Reinhardt D, Tomizawa D, Kiyokawa N, Lammens T, De Moerloose B, Zhou L, Hori H, Moorman A, Moore AS, Hrusak O, Meschinchi S, Orgel E, Devidas M, Borowitz M, Wood B, Heerema NA, Carrol A, Yang Y-L, Smith MA, Davidsen TM, Hermida LC, Gesuwan P, Marra MA, Ma Y, Mungall AJ, Moore RA, Jones SJM, Dang L, Newman S, Liu Y, Zhang J, Nichols KE, Downing JR, Cao X, Shi L, Pounds S, Pei D, Auvil JMG, Gerhard DS, Hunger SP, Inaba H, Mullighan CG (2018).  The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature Sep 12, 2018. PMID: 30209392.

Rubnitz JE, Lacayo NJ, Inaba H, Heym K, Ribeiro RC, Taub J, McNeer J, Degar B, Schiff D, Yeoh AE, Coustan-Smith E, Wang L, Triplett B, Raimondi SC, Klco J, Choi J, Pounds S, Pui CH.  Clofarabine Can Replace Anthracyclines and Etoposide in Remission Induction Therapy for Childhood Acute Myeloid Leukemia: The AML08 Multicenter, Randomized Phase III Trial.  Journal of Clinical Oncology Aug 10;37(23):2072-2081, 2019.

Ma X, Liu Y, Liu Y, Alexandrov LB, Edmonson MN, Gawad C, Zhou X, Li Y, Rusch MC, Easton J, Huether R, Gonzalez-Pena V, Wilkinson MR, Hermida LC, Davis S, Sioson E, Pounds S, Cao X, Ries RE, Wang Z, Chen X, Dong L, Diskin SJ, Smith MA, Guidry Auvil JM, Meltzer PS, Lau CC, Perlman EJ, Maris JM, Meshinchi S, Hunger SP, Gerhard DS, Zhang J. Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. Nature Mar 15;555(7696):371-376, 2018. doi: 10.1038/nature25795. Epub 2018 Feb 28. PubMed PMID: 29489755.

Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, Mccastlain K, Edmonson M, Pounds SB, Shi L, Zhou X, Ma Xi, Sioson E, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Auvil JG, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Wilman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino BP, Downing JR, Lo ML, Hunger SP, Zhang J, Mullighan CG. The Genomic Landscape of Pediatric and Young Adult T-Lineage Acute Lymphoblastic Leukemia. Nature Genetics 49:1211-1218, 2017.

Zhu L, Poppleton H, Finkelstein D, Gao CL, Shi L, Wang Y-D, Terrada LT, Wang K, Utley S, Pounds S, Neale G, Ellison DW, Onar-Thomas A, Gilbertson RJ. Multi-organ mapping of cancer risk. Cancer Cell 166:1132-1146, 2016.  

Cao X, Crews KR, Downing J, Lamba J, Pounds SB. CC-PROMISE Effectively Integrates Two Forms of Molecular Data with Multiple Biologically Related Endpoints. BMC Bioinformatics 17:382, 2016.

Pounds S, Cheng C, Li S, Liu Z, Zhang J, Mullighan C. A Genomic Random Interval Model for Statistical Analysis of Genomic Lesion Data. Bioinformatics 29:2088-95, 2013.

Last update: October 2021