Charles J. Russell, PhD
Charles J. Russell, PhD

Charles J. Russell, PhD

Associate Member, St. Jude Faculty



PhD – University of California at Berkeley
BS – Chemistry, Millikin University

Research Interests

  • Molecular mechanisms of infectious diseases caused by emerging influenza viruses and paramyxoviruses
  • Negative-strand RNA virus replication and pathogenesis, focusing on influenza viruses and paramyxoviruses
  • Viral envelope glycoproteins as targets for novel vaccines and drugs

Selected Publications

Russier M, Yang G, Rehg JE, Wong S-S, Mostafa HH, Fabrizio T, Barman S, Krauss S, Webster RG, Webby RJ, Russell CJ. Molecular requirements for a pandemic influenza virus: an acid-stable hemagglutinin protein. Proc Natl Acad Sci USA 113:1636-1641, 2016.

Yoon SW, Chen N, Ducatez MF, McBride R, Barman S, Fabrizio TP, Webster RG, Haliloglu T, Paulson JC, Russell CJ, Hertz T, Ben-Tal N, Webby RJ. Changes to the dynamic nature of hemagglutinin and the emergence of the 2009 pandemic H1N1 influenza virus. Sci Rep 5:12828, 2015.

Zaraket H, Baranovich T, Kaplan B, Carter R, Song M-S, Paulson J, Rehg J, Bahl J, Crumpton J, Seiler P, Edmonson M, Wu G, Karlsson E, Fabrizio T, Zhu H, Guan Y, Husain M, Schultz-Cherry S, Krauss S, McBride R, Webster RG, Govorkova E, Zhang J, Russell C, Webby R. Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck. Nat Commun 6:6553, 2015.

Russell CJ, Hurwitz JL. Sendai virus as a backbone for vaccines against RSV and other human paramyxoviruses. Exp Rev Vaccines 9:1-12, 2015.

Burke CW, Li M, Hurwitz JL, Vogel P, Russell CJ. Relationships between dissemination of primary parainfluenza virus infection in the respiratory tract, mucosal and peripheral immune responses, and protection from reinfection: a non-invasive bioluminescence imaging study. J Virol 89:3568-3583, 2015.

Adderson E, Branum K, Sealy RE, Jones BG, Surman SL, Penkert R, Freiden P, Slobod KS, Gaur AH, Hayden RT, Allison K, Howlett N, Utech J, Allay J, Knight J, Sleep S, Meagher M, Russell CJ, Portner A, Hurwitz JL. Safety and immunogenicity of an intranasal Sendai virus-based parainfluenza virus type 1 vaccine in 3-6 year old children. Clin Vaccine Immunol 22:298-303, 2015.

Russell CJ. Acid-induced membrane fusion by the hemagglutinin protein and its role in influenza virus biology. Curr Top Microbiol Immunol 385:93-116, 2014.

Elbahesh H, Cline T, Baranovich T, Govorkova EA, Schultz-Cherry S, Russell CJ. Novel roles of focal adhesion kinase in cytoplasmic entry and replication of influenza A viruses. J Virol 88:6714-6728, 2014.

Burke CW, Bridges O, Brown S, Rahija R, Russell CJ. Mode of parainfluenza virus transmission determines the dynamics of primary infection and protection from reinfection. PLoS Pathogens 9(11):e1003786, 2013.

Zaraket H, Bridges OA, Duan S, Baranovich T, Yoon S-W, Reed ML, Salomon R, Webby RJ, Webster RG, Russell CJ. Increased hemagglutinin protein stability enhances H5N1 influenza virus growth in the nasopharynx but is insufficient for transmission in ferrets. J Virol 87:9911-9922, 2013.

Fouchier RAM, Kawaoka Y, Carona C, Compans RW, Garcia-Sastre A, Govorkova EA, Guan Y, Herfst S, Orenstein WA, Peiris JSM, Perez DR, Richt J, Russell C, Schultz-Cherry SL, Smith DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG. Gain-of-Function experiments on H7N9. Science 341:612-613, 2013.

Mason JN, Elbahesh H, Russell CJ. Influence of antigen insertion site and vector dose on immunogenicity and protective capacity in Sendai virus-based human parainfluenza virus type 3 vaccines. J Virol 87:5959-5969, 2013.

Galloway SE, Reed ML, Russell CJ, Steinhauer DA. Influenza HA subtypes demonstrate divergent phenotypes for cleavage activation and pH of fusion: implications for host range and adaptation.PLoS Pathogens 9:e1003151, 2013.

Zaraket H, Bridges OA, Russell CJ. The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in mice. J Virol 87:4826-4834, 2013. *Spotlight article of significant interest selected by the Editors.

Russell CJ. Stalking Influenza Diversity with a Universal Antibody. The New England Journal of Medicine 365:1541-2, 2011.

DuBois RM*, Zaraket H*, Reddivari M, Heath RJ, White SW, Russell CJ. Acid stability of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity. PLoS Pathogens 7:e1002398, 2011. *Joint first authors.

Burke CW*, Mason JN*, Surman SL, Jones BG, Dalloneau E, Hurwitz JL, Russell CJ. Illumination of parainfluenza virus infection and transmission in living animals reveals a tissue-specific dichotomy. PLoS Pathogens 7:e1002134, 2011. *Joint first authors.

DuBois RM, Aguilar‐Yañez JM, Mendoza‐Ochoa GI, Oropeza-Almazán Y, Schultz-Cherry S, Alvarez MM, White SW, Russell CJ. The receptor-binding domain of influenza virus hemagglutinin protein produced in Escherichia coli folds into its native, immunogenic structure. J Virol 85:865-872, 2011.

Vanderlinden E, Göktaş F, Cesur Z, Froeyen M, Reed ML, Russell CJ, Cesur N, Naesens L. Novel inhibitors of influenza virus fusion: structure activity relationship and interaction with the viral hemagglutinin. J Virol 84:4277-4288, 2010.

Reed ML, Bridges OA, Seiler P, Kim J-K, Yen H-L, Salomon R, Govorkova EA, Webster RG, Russell CJ. The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks. J Virol 84:1527-1535, 2010.

Luque LE, Bridges OA, Mason JN, Boyd KL, Portner A, Russell CJ. Residues in the heptad repeat A region of the fusion (F) protein modulate the virulence of Sendai virus in mice. J Virol 84:810-821, 2010. *Spotlight article of significant interest selected by authors.

Boyd V, Mason J, Hanumesh P, Price J, Russell CJ, Webb TR. 2-Substituted-4,5-Dihydroxypyrimidine-6-Carboxamide RNA-Dependent RNA Polymerase Targeted Libraries. J Combinatorial Chem 11:1100-1104, 2009.

Watanabe M, Mishin VP, Brown SA, Russell CJ, Boyd K, Babu YS, Taylor G, Xiong X, Yan X, Portner A, Alymova IV. Effect of hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 on growth and pathogenicity of Sendai/human parainfluenza type 3 chimera virus in mice. Antimicrob Agents Chemother 53:3942-3951, 2009.

Reed ML, Yen H-L, DuBois RM, Bridges OA, Salomon R, Webster RG, Russell CJ. Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin (HA) protein. J Virol 83:3568-3580, 2009.

Jones B, Zhan X, Mishin V, Slobod KS, Surman S, Russell CJ, Portner A, Hurwitz JL. Human PIV-2 recombinant Sendai virus (rSeV) elicits durable immunity and combines with two additional rSeVs to protect against hPIV-1, hPIV-2, hPIV-3, and RSV. Vaccine 27:1848-1857, 2009.

Zhan X, Slobod KS, Krishnamurthy S, Luque LE, Takimoto T, Jones B, Surman S, Russell CJ, Portner A, Hurwitz JL. Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections.Vaccine 26:3480-3488, 2008.

Luque LE, Russell CJ. Spring-loaded heptad repeat residues regulate the expression and activation of the paramyxovirus fusion (F) protein. J Virol 81:3130-3141, 2007.

Russell CJ, Luque LE. The structural basis of paramyxovirus invasion. Trends Microbiol 14:243-246, 2006.

Russell CJ, Webster RG. The genesis of a pandemic influenza virus. Cell 123:368-371, 2005.

Russell CJ, Jardetzky TS, Lamb RA. Conserved glycine residues in the fusion peptide of the paramyxovirus fusion protein regulate activation of the native state. J Virol 78:13727-13742, 2004.

Waning DL, Russell CJ, Jardetzky TS, Lamb RA. Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail. Proc Natl Acad Sci USA 101:9217-9222, 2004.

Russell CJ, Kantor KL, Jardetzky TS, Lamb RA. A dual-functional paramyxovirus F protein regulatory switch segment: activation and membrane fusion. J Cell Biol 163:363-374, 2003.

Takeda M, Leser GP, Russell CJ, Lamb RA. Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion. Proc Natl Acad Sci USA 100:14610-14617, 2003.

Russell CJ, Jardetzky TS, Lamb RA. Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion. EMBO Journal 20:4024-4034, 2001.

Last update: February 2016