Teresa Santiago, MD
Teresa Santiago, MD

Teresa Santiago, MD

Assistant Member, St. Jude Faculty

  • Director, Coagulation Laboratory



MD – University of Pernambuco, Brazil
Residency (Anatomical and Clinical Pathology) – University of Tennessee Health Science Center, Memphis, TN
Fellowship (Pediatric Pathology) – University of Tennessee Health Science Center, Memphis, TN; St. Jude Children’s Research Hospital; Le Bonheur Children’s Hospital

Research Interests

  • Laboratory quality improvement and assessment in developing countries
  • Coagulopathies
  • Solid tumors of childhood

Selected Publications

Epperly R, Furman W, Hines M, Santiago T, Li Y, Madden R, Mamcarz E, Cervi D, Federico S, Triplett B, Talleur A. Secondary hemophagocytic syndrome after autologous hematopoietic cell transplant and immune therapy for neuroblastoma. Pediatr Blood Cancer.  Aug 12:e27964. doi: 10.1002/pbc.27964. 2019 [Epub ahead of print] PMID: 31407508 

Santiago T, Tarek N, Boulos F, Hayes C, Jeha S, Raimondi S, Rodriguez-Galindo C. Correlation Between MYCN Gene Status and MYCN Protein Expression in Neuroblastoma: A Pilot Study To Propose the Use of MYCN Immunohistochemistry in Limited-Resource Areas. J Glob Oncol. 2019 Jul;5:1-7. doi: 10.1200/JGO.19.00135. PMID: 31365300

Malik F, Santiago T, Bahrami A, Davis E, McCarville B, Newman S, Azzato EM, Davidoff AM, Brennan R, Ellison DW, Clay MR. Dedifferentiation in SDH-Deficient Gastrointestinal Stromal Tumor: A Report With Histologic, Immunophenotypic, and Molecular Characterization. Pediatr Dev Pathol. 2019 Oct;22(5):492-498. doi: 10.1177/1093526619846222. Epub 2019 May 9. PMID: 31072206

Lucas JT Jr, McCarville MB, Cooper DA, Doubrovin M, Wakefield D, Santiago T, Li Y, Li X, Krasin M, Santana V, Furman W, Davidoff AM. Implications of Image-Defined Risk Factors and Primary-Site Response on Local Control and Radiation Treatment Delivery in the Management of High-Risk Neuroblastoma: Is There a Role for De-escalation of Adjuvant Primary-Site Radiation Therapy? Int J Radiat Oncol Biol Phys. 2019 Mar 15;103(4):869-877. doi: 10.1016/j.ijrobp.2018.11.041. Epub 2018 Nov 26. PMID: 30496881 [PubMed - indexed for MEDLINE]

Mukkada S, Metzger ML, Santiago T, Wolf J. Severe Progressive Mycobacterium avium Complex Infection Associated With Brentuximab Vedotin Therapy. J Pediatric Infect Dis Soc. 2018 Nov 12. doi: 10.1093/jpids/piy109. [Epub ahead of print] PMID: 30423147 

Santiago T, Hayes C, Polanco AC, Miranda L, Aybar A, Gomero B, Orellana E, Anglade F, Toledo González ML, Ruiz E, Espino-Durán M, Rodriguez-Galindo C, Metzger ML. Improving Immunohistochemistry Capability for Pediatric Cancer Care in the Central American and Caribbean Region: A Report From the AHOPCA Pathology Working Group. J Glob Oncol. 2018 Sep;4:1-9. doi: 10.1200/JGO.17.00187. PMID: 30241256 

Ortega-Laureano L, Santiago T, Maron G, Davidoff AM, Fernandez-Pineda I.Surgical lung biopsy in children after hematopoietic cell transplantation. J Pediatr Surg. 2018 Jun;53(6):1129-1133. doi: 10.1016/j.jpedsurg.2018.02.069. Epub 2018 Mar 6. PMID: 29602553 [PubMed - indexed for MEDLINE]

Santiago T, Clay MR, Allen SJ, Orr BA. Recurrent BCOR internal tandem duplication and BCOR or BCL6 expression distinguish primitive myxoid mesenchymal tumor of infancy from congenital infantile fibrosarcoma. Mod Pathol. 2018 Feb;31(2):374. doi: 10.1038/modpathol.2017.178. PMID: 29430000 [PubMed] 

Blackburn TE, Santiago T, Burrows PD. FCRLA-A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells. Curr Top Microbiol Immunol. 2017;408:47-65. doi: 10.1007/82_2017_40. PMID: 28879521 [PubMed - indexed for MEDLINE]

Merabi Z, Boulos F, Santiago T, Jenkins J, Abboud M, Muwakkit S, Tarek N, Zaatari G, Jeha S, El-Solh H, Saab R. Pediatric cancer pathology review from a single institution: Neuropathology expert opinion is essential for accurate diagnosis of pediatric brain tumors. Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26709. Epub 2017 Jul 4. PMID: 28675683 [PubMed - indexed for MEDLINE]

Santiago T, Clay MR, Azzato E, Newman S, Fernandez-Pineda I, Nichols KE, Zhang J, Downing JR, Davidoff A, Brennan RC, Ellison DW. Clear cell sarcoma of kidney involving a horseshoe kidney and harboring EGFR internal tandem duplication. Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26602. Epub 2017 Apr 25. PMID: 28440018 [PubMed - indexed for MEDLINE]

Santiago T, Clay MR, Allen SJ, Orr BA. Recurrent BCOR internal tandem duplication and BCOR or BCL6 expression distinguish primitive myxoid mesenchymal tumor of infancy from congenital infantile fibrosarcoma. Mod Pathol. 2017 Jun;30(6):884-891. doi: 10.1038/modpathol.2017.12. Epub 2017 Mar 3. Erratum in: Mod Pathol. 2018 Feb;31(2):374. PMID: 28256570 [PubMed - indexed for MEDLINE] 

Qaddoumi I, Orisme W, Wen J, Santiago T, Gupta K, Dalton JD, Tang B, Haupfear K, Punchihewa C, Easton J, Mulder H, Boggs K, Shao Y, Rusch M, Becksfort J, Gupta P, Wang S, Lee RP, Brat D, Peter Collins V, Dahiya S, George D, Konomos W, Kurian KM, McFadden K, Serafini LN, Nickols H, Perry A, Shurtleff S, Gajjar A, Boop FA, Klimo PD Jr, Mardis ER, Wilson RK, Baker SJ, Zhang J, Wu G, Downing JR, Tatevossian RG, Ellison DW. Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology. Acta Neuropathol. 2016 Jun;131(6):833-45. doi: 10.1007/s00401-016-1539-z. Epub 2016 Jan 25. PMID: 26810070 [PubMed - indexed for MEDLINE] 

Show More

Santiago TC, Jenkins JJ. Histopathologic Diagnosis of Pediatric Neoplasms: A Review of International Consultations. Archives of Pathology & Laboratory Medicine Nov;137(11);1648-1653, 2013.

Jones KL, Pivnick EK, Hines-Dowell S, Weese-Mayer DE, Berry-Kravis EM, Santiago T, Nnorom C, Pourcyrous M. A Triple Threat: Down syndrome, Congenital Central Hypoventilation Syndrome, and Hirschsprung. Disease Pediatrics 2011-3844, 2012. doi:10.1542/peds.

Santiago TC, Jenkins JJ, Pedrosa F, Billups C, Quintana Y, Ribeiro RC, Qaddoumi I. Improving the Histopathology Diagnosis of Pediatric Malignancies in a low-resource setting by combining focused training and Telepathology strategies. Pediatr Blood Cancer Aug;59(2):221-5, 2012. doi: 10.1002/pbc.24071.

Burrows P, Santiago T, Kulemzin S, Reshetnikova E, Chikaev N, Volkova O, Mechetina L, Zhao M, Davis R, Taranin A, Najakshin A, Hendershot L FCRLA is an intracellular FcR-related protein that binds IgM, IgG and IgA isotypes in B cells. J Immunol 186:45, 2011.

Santiago T, Kulemzin SV, Reshetnikova ES, Chikaev NA, Volkova OY, Mechetina LV, Zhao M, Davis RS, Taranin AV, Najakshin AM, Hendershot LM, Burrows PD. FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA. Int Immunol 23(1):43-53, 2011. PMID 21149418.

Santiago T, Hendershot L, Burrows P. Expression and Funcion of FcRLA, an Fc receptor related intracellular protein. Clinical Immunology 127(1):154, 2008.

Veras Sobral AP, de Oliveira Lima DN, Cazal C, Santiago T, das Graças Granja Mattos M, Melo B, de Souza Andrade ES. Myxoid liposarcoma of the lip: correlation of histological and cytological features and review of the literature. J Oral Maxillofac Surg Aug;65(8):1660-4, 2007. PMID: 17656299.

Last update: September 2019

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