Charles J. Sherr, MD, PhD
Charles J. Sherr, MD, PhD

Charles J. Sherr, MD, PhD

Member, St. Jude Faculty

  • Chair, Tumor Cell Biology Department
  • Herrick Foundation Chair

Departments

Education

MD – New York University School of Medicine
PhD – New York University Graduate School of Arts and Sciences

Honors & Awards

  • 2019 C. Chester Stock Award Lectureship
  • 2013 Elected Fellow, American Academy of Arts and Sciences
  • 2013 Elected Inaugural Fellow, Academy of the American Association for Cancer Research
  • 2013 American-Italian Cancer Foundation Prize
  • 2010 Elected Fellow, American Association for the Advancement of Science
  • 2004 Elected to the US Institute of Medicine
  • 2004 General Motors Cancer Foundation Mott Prize
  • 2003 AACR Landon Prize for Basic Cancer Research
  • 2000 Bristol Myers-Squibb Achievement Award for Basic Cancer Research
  • 2000 AACR Pezcoller Award
  • 1995 Elected to the US National Academy of Sciences

Research Interests

Our laboratory has traditionally focused on the mechanisms by which mitogens relay proliferative signals that affect progression through the mammalian cell division cycle. Current projects emphasize the rate limiting effects of cyclins and cyclin-dependent kinases (CDKs) on G1 phase progression; the role of CDK inhibitors (INK4 and Cip/Kip proteins) in cell cycle control, organismal development, and tumorigenesis in vivo; the activity of particular tumor suppressors, including INK4A-ARF, p53, and RB, in cell line establishment, senescence, stem cell biology, and protecting against oncogenic insults. Postdoctoral fellows and graduate students receive joint supervision by Drs. Roussel and Sherr in a multi-disciplinary program that seeks to maximize trainees’ abilities to successfully perform novel and speculative experiments.

Selected Publications

van Oosterwijk JG, Tillman H, Sherr CJ. Sexually dimorphic tumor suppression by small mitochondrial Arf. Oncotarget Feb 8;10(12):1235-1237, 2019. doi: 10.18632/oncotarget.26651. eCollection 2019 Feb 8. PMID:30815226

Ruscetti M, Leibold J, Bott MJ, Fennell M, Kulick A, Salgado NR, Chen CC, Ho YJ, Sanchez-Rivera FJ, Feucht J, Baslan T, Tian S, Chen HA, Romesser PB, Poirier JT, Rudin CM, de Stanchina E, Manchado E, Sherr CJ, Lowe SW. NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science Dec 21;362(6421):1416-1422, 2018. doi: 10.1126/science.aas9090. PMID: 30573629

Sherr CJ.Acquired palbociclib resistance in KRAS-mutant lung cancer. Oncotarget Aug 28;9(67):32734-32735, 2018. doi: 10.18632/oncotarget.26027. eCollection 2018 Aug 28. No abstract available. PMID:30214680

Vo BT, Kwon JA, Li C, Finkelstein D, Xu B, Orr BA, Sherr CJ, Roussel MF. Mouse medulloblastoma driven by CRISPR activation of cellular Myc. Sci Rep Jun 7;8(1):8733, 2018. doi: 10.1038/s41598-018-24956-1. PMID:29880921

van Oosterwijk JG, Li C, Yang X, Opferman JT, Sherr CJ. Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice. Proc Natl Acad Sci U S A Jul 11;114(28):7420-7425, 2017. doi: 10.1073/pnas.1707292114. Epub 2017 Jun 26. PMID:28652370

Vo BT, Li C, Morgan MA, Theurillat I, Finkelstein D, Wright S, Hyle J, Smith SMC, Fan Y, Wang YD, Wu G, Orr BA, Northcott PA, Shilatifard A, Sherr CJ, Roussel MF. Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma. Cell Rep Mar 21;18(12):2907-2917, 2017. doi: 10.1016/j.celrep.2017.02.073. PMID:28329683

Sherr CJ. A New Cell-Cycle Target in Cancer - Inhibiting Cyclin D-Dependent Kinases 4 and 6. N Engl J Med Nov 17;375(20):1920-1923, 2016. PMID: 27959598

Sherr CJ, Beach D, Shapiro GI. Targeting CDK4 and CDK6: from discovery to therapy. Cancer Discov 6(4):1-15, 2016. [EPub ahead of print 2015, PMID 26658964]

Sharpless NE, Sherr CJ. Forging a signature of in vivo senescence. Nat Rev Cancer 15(7):397-408, 2015.

Appelmann I, Rillahan CD, de Stanchina E, Carbonetti G, Chen C, Lowe SW, Sherr CJ. Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL. Blood 125(9):1444-1451, 2015.

Huang CH, Lujambio A, Zuber J, Tschaharganeh DF, Doran MG, Evans MJ, Kitzing T, Zhu N, de Stanchina E, Sawyers CL, Armstrong SA, Lewis JS, Sherr CJ, Lowe SW. CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. Genes Dev 28(16):1800-1814, 2014.

Li C, Qi R, Singleterry R, Hyle J, Balch A, Li X, Sublett J, Berns H, Valentine M, Valentine V, Sherr CJ. Simultaneous gene editing by injection of mRNAs encoding transcription activator-like effector nucleases into mouse zygotes. Mol Cell Biol 34(9):1649-1658, 2014.

Li C, Finkelstein D, Sherr CJ. Arf tumor suppressor and miR-205 regulate cell adhesion and formation of extraembryonic endoderm from pluripotent stem cells. Proc Natl Acad Sci USA 110(12):E1112-1121, 2013.

Sherr CJ. Ink4-Arf locus in cancer and aging. Wiley Interdiscip Rev Dev Biol (WIRES) 1(5):731-741, 2012.

Treanor LM, Volanakis EJ, Zhou S, Lu T, Sherr CJ, Sorrentino BP. Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies. Blood 117(20):5453-5462, 2011.

Boulos N, Mulder HL, Calabrese CR, Morrison JB, Rehg JE, Relling MV, Sherr CJ, Williams RT. Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 117(13):3585-3595, 2011.

Last update: June 2019