Interleukin-2 (Aldesleukin)

What is Interleukin-2?

Interleukin-2 (also known as Aldesleukin and IL-2) is similar to a natural substance made by the body. Usually, the body makes small amounts of interleukin-2 that help white blood cells fight infection. It is now possible to make interleukin-2 outside the body and to give humans much higher doses than their own bodies make. It is available as a clear liquid given by vein (IV) or as a subcutaneous (under the skin) injection.

How Interleukin-2 is given

Interleukin-2 can be infused through a CADD pump over a 24-hour period. You must to return to the Medicine Room around the same time each day to have a new dose of medicine connected to the CADD pump.

Interleukin-2 can be given as a low dose shot under the skin every other day. Each dose will be in a syringe with subcutaneous needle and alcohol pad included. Do not give more than one (1) shot per dose. Interleukin-2 has a short expiration period when made by the pharmacy. You must return to the Outpatient Pharmacy to pick up any remaining doses for each cycle (up to 6 doses per cycle). Refer to “Do You Know... How to Give Subcutaneous Injections” for details on how to give a dose.

Possible side effects of Interleukin-2

Early

• Fevers and chills
• Itching and rash
• Flu-like symptoms like headache, tiredness, aches and pains

Later (more than a day after treatment starts)

• Diarrhea
• Nausea or vomiting
• Feeling tired or weak
• Feeling lightheaded or dizzy
• Fainting spells
• Blurred vision
• Loss of appetite
• Decrease in the amount of urine
• Weight gain
• Anemia
• Low blood pressure

These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse.

In case of a severe side effect or reaction, call your doctor, nurse, or pharmacist at 901-595-3300. If you are outside the Memphis area, dial toll-free 1-866-2STJUDE (1-866-278-5833).

Special instructions for Interleukin-2

• Tell your doctor right away if you have any of these side effects while receiving interleukin-2:
  • Chest tightness, wheezing, trouble breathing
  • Signs of infection such as fever or chills
  • Severe dizziness or passing out (signs of low blood pressure)
  • Change in clear, logical thinking
  • Swelling of legs or belly
  • Unusual weight gain
  • Unable to pass urine
  • Feeling extremely tired or weak
• Interleukin-2 syringes should be stored in the refrigerator. Pay close attention to the expiration date written on the label.
• Check with your doctor before starting any new medicines, including over-the-counter, natural products, or vitamins.