Joshua Wolf, PhD, MBBS
Joshua Wolf, PhD, MBBS

Joshua Wolf, PhD, MBBS

Associate Member, St. Jude Faculty

Departments

Education

BA – University of Melbourne
MBBS – University of Melbourne
PhD - University of Melbourne

Research Interests

  • Prediction, Prevention and Treatment of Infections in Immunocompromised Children
  • Management of Device-Associated Infections

Selected Publications

Lehrnbecher T, Fisher BT, Phillips B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Castagnola E, Davis BL, Dupuis LL, Egan G, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, van de Wetering M, Wolf J, Cabral S, Robinson PD, Sung L, et al. Guideline for Antibacterial Prophylaxis Administration in Pediatric Cancer and Hematopoietic Stem Cell Transplantation. Clin Infect Dis Jun 24;71(1):226-236, 2020. doi: 10.1093/cid/ciz1082. PMID: 31676904

Wolf J, Milstone AM, et al. Vascular Access in Children to Prevent and Treat Infectious Diseases. Pediatrics Jun;145(Suppl 3):S290-S291, 2020. doi: 10.1542/peds.2019-3474L. PMID: 32482742

Ullman AJ, Bernstein SJ, Brown E, Aiyagari R, Doellman D, Faustino EVS, Gore B, Jacobs JP, Jaffray J, Kleidon T, Mahajan PV, McBride CA, Morton K, Pitts S, Prentice E, Rivard DC, Shaughnessy E, Stranz M, Wolf J, Cooper DS, Cooke M, Rickard CM, Chopra V, et al. The Michigan Appropriateness Guide for Intravenous Catheters in Pediatrics: miniMAGIC. Pediatrics Jun;145(Suppl 3):S269-S284, 2020. doi: 10.1542/peds.2019-3474I. PMID: 32482739

Getzenberg RB, Hijano DR, Hakim H, Dallas RH, Ferrolino JA, Brazelton de Cardenas J, Garner CD, Tang L, Su Y, Wolf J, Hayden RT, Maron G, et al. Rothia mucilaginosa Infections in Pediatric Cancer Patients. J Pediatric Infect Dis Soc May 25:piaa047, 2020. doi: 10.1093/jpids/piaa047. PMID: 32448911

Chilambi GS, Nordstrom HR, Evans DR, Ferrolino JA, Hayden RT, Marón GM, Vo AN, Gilmore MS, Wolf J, Rosch JW, Van Tyne D, et al. Evolution of vancomycin-resistant Enterococcus faecium during colonization and infection in immunocompromised pediatric patients. Proc Natl Acad Sci U S A May 26;117(21):11703-11714, 2020. doi: 10.1073/pnas.1917130117. PMID: 32393645

Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich M, Goldman DL, Groves HE, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, Nakamura MM, et al. Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2. J Pediatric Infect Dis Soc Apr 22:piaa045, 2020. doi: 10.1093/jpids/piaa045. PMID: 32318706  

Hrusak O, Kalina T, Wolf J, Balduzzi A, Provenzi M, Rizzari C, Rives S, Del Pozo Carlavilla M, Alonso MEV, Domínguez-Pinilla N, Bourquin JP, Schmiegelow K, Attarbaschi A, Grillner P, Mellgren K, van der Werff Ten Bosch J, Pieters R, Brozou T, Borkhardt A, Escherich G, Lauten M, Stanulla M, Smith O, Yeoh AEJ, Elitzur S, Vora A, Li CK, Ariffin H, Kolenova A, Dallapozza L, Farah R, Lazic J, Manabe A, Styczynski J, Kovacs G, Ottoffy G, Felice MS, Buldini B, Conter V, Stary J, Schrappe M, et al. Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. Eur J Cancer Jun;132:11-16, 2020. doi: 10.1016/j.ejca.2020.03.021. PMID: 32305831

Karol SE, Alexander TB, Budhraja A, Pounds SB, Canavera K, Wang L, Wolf J, Klco JM, Mead PE, Das Gupta S, Kim SY, Salem AH, Palenski T, Lacayo NJ, Pui CH, Opferman JT, Rubnitz JE, et al. Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study. Lancet Oncol Apr;21(4):551-560, 2020. doi: 10.1016/S1470-2045(20)30060-7. PMID: 32171069

Green AM, Wolf J, et al. Early Recognition of Sepsis Saves Lives, but a 1-Hour Antibiotic Target Misses the Mark. Hosp Pediatr Apr;10(4):381-383, 2020. doi: 10.1542/hpeds.2020-0017. PMID: 32122987

Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P, et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med Feb;46(Suppl 1):10-67, 2020. doi: 10.1007/s00134-019-05878-6. PMID: 32030529

Woods-Hill CZ, Koontz DW, King AF, Voskertchian A, Colantuoni EA, Miller MR, Fackler JC, Bonafide CP, Milstone AM, Xie A; Bright Star Authorship group, et al. Practices, Perceptions, and Attitudes in the Evaluation of Critically Ill Children for Bacteremia: A National Survey. Pediatr Crit Care Med Jan;21(1):e23-e29, 2020. doi: 10.1097/PCC.0000000000002176. PMID: 31702704

Goggin KP, Gonzalez-Pena V, Inaba Y, Allison KJ, Hong DK, Ahmed AA, Hollemon D, Natarajan S, Mahmud O, Kuenzinger W, Youssef S, Brenner A, Maron G, Choi J, Rubnitz JE, Sun Y, Tang L, Wolf J, Gawad C, et al. Evaluation of Plasma Microbial Cell-Free DNA Sequencing to Predict Bloodstream Infection in Pediatric Patients With Relapsed or Refractory Cancer. JAMA Oncol Dec 19;6(4):552-6, 2019. doi: 10.1001/jamaoncol.2019.4120. PMID: 31855231

Wolf J, Kalocsai K, Fortuny C, Lazar S, Bosis S, Korczowski B, Petit A, Bradford D, Croos-Dabrera R, Incera E, Melis J, van Maanen R, et al. Safety and efficacy of fidaxomicin and vancomycin in children and adolescents with Clostridioides (Clostridium) difficile infection: a phase 3, multicenter, randomized, single-blind clinical trial (SUNSHINE). Clin Infect Dis Nov 27:ciz1149, 2019. doi: 10.1093/cid/ciz1149. PMID: 31773143

Mukkada S, Metzger ML, Santiago T, Wolf J, et al. Severe Progressive Mycobacterium avium Complex Infection Associated With Brentuximab Vedotin Therapy. J Pediatric Infect Dis Soc Sep 25;8(4):371-373, 2019. doi: 10.1093/jpids/piy109. PMID: 30423147

Wolf J, Margolis E, et al. Effect of Antimicrobial Stewardship on Outcomes in Patients With Cancer or Undergoing Hematopoietic Stem Cell Transplantation. Clin Infect Dis Sep 18:ciz903, 2019. doi: 10.1093/cid/ciz903. PMID: 31633164

Schlapbach LJ, Weiss SL, Wolf J, et al. Reducing Collateral Damage From Mandates for Time to Antibiotics in Pediatric Sepsis-Primum Non Nocere. JAMA Pediatr May 1;173(5):409-410, 2019. doi: 10.1001/jamapediatrics.2019.0174. PMID: 30882879

Finch ER, Janke LJ, Smith CA, Karol SE, Pei D, Cheng C, Kaste SC, Inaba H, Pui CH, Wolf J, Relling MV, et al. Bloodstream infections exacerbate incidence and severity of symptomatic glucocorticoid-induced osteonecrosis. Pediatr Blood Cancer Jun;66(6):e27669, 2019. doi: 10.1002/pbc.27669. PMID: 30758124

Wolf J, Connell TG, Curtis N, Flynn PM, et al. Ethanol lock therapy. Lancet Infect Dis Dec;18(12):1306, 2018. doi: 10.1016/S1473-3099(18)30678-9. PMID: 30507448

Cheung YT, Eskind A, Inaba H, Hudson MM, Pui CH, Krull KR, Wolf J, et al. Association of Bacteremic Sepsis With Long-term Neurocognitive Dysfunction in Pediatric Patients With Acute Lymphoblastic Leukemia. JAMA Pediatr Nov 1;172(11):1092-1095, 2018. doi: 10.1001/jamapediatrics.2018.2500. PMID: 30264151

Hakim H, Dallas R, Wolf J, Tang L, Schultz-Cherry S, Darling V, Johnson C, Karlsson EA, Chang TC, Jeha S, Pui CH, Sun Y, Pounds S, Hayden RT, Tuomanen E, Rosch JW, et al. Gut Microbiome Composition Predicts Infection Risk During Chemotherapy in Children With Acute Lymphoblastic Leukemia. Clin Infect Dis Aug 1;67(4):541-548, 2018. doi: 10.1093/cid/ciy153. PMID: 29518185

Quinn M, Fannin JT, Sciasci J, Bragg A, Campbell PK, Carias D, Crews KR, Gregornik D, Jeha S, Maron G, Pauley JL, Swanson HD, Wolf J, Greene W, et al. Pentamidine for Prophylaxis against Pneumocystis jirovecii Pneumonia in Pediatric Oncology Patients Receiving Immunosuppressive Chemotherapy. Antimicrob Agents Chemother Jul 27;62(8):e00173-18, 2018. doi: 10.1128/AAC.00173-18. PMID: 29866879

Wolf J, Connell TG, Allison KJ, Tang L, Richardson J, Branum K, Borello E, Rubnitz JE, Gaur AH, Hakim H, Su Y, Federico SM, Mechinaud F, Hayden RT, Monagle P, Worth LJ, Curtis N, Flynn PM, et al. Treatment and secondary prophylaxis with ethanol lock therapy for central line-associated bloodstream infection in paediatric cancer: a randomised, double-blind, controlled trial. Lancet Infect Dis Aug;18(8):854-863, 2018. doi: 10.1016/S1473-3099(18)30224-X. PMID: 29884572

Show More

Sun Y, Huskey R, Tang L, Inaba H, Rubnitz J, Wolf J. Adverse effects of intravenous vancomycin-based prophylaxis during therapy for pediatric acute myeloid leukemia, Antimicrobial Agents and Chemotherapy 62:e01838-17, 2018.

Wolf J, Tang L, Flynn PM, Pui C-H, Gaur AH, Sun Y, Inaba H, Stewart T, Hayden RT, Hakim H, Jeha S. Levofloxacin prophylaxis during induction therapy for pediatric acute lymphoblastic leukemia. Clinical Infectious Diseases 65:1798-8, 2017.

Honsa ES, Cooper VS, Mhaissen MN, Frank M, Shaker J, Iverson A, Rubnitz J, Hayden RT, Lee RE, Rock C, Tuomanen EI, Wolf J*, Rosch JW*. RelA mutant Enterococcus faecium with multi-antibiotic tolerance arising in an immunocompromised host. mBio 8:e02124-16, 2017. *Co-corresponding authors.

Inaba H, Pei D, Wolf J, Hayden RT, Go M, Varechtchouk O, Hahn T, Buaboonnam J,. Metzger ML, Rubnitz JE, Ribeiro RC, Sandlund JT, Jeha S, Cheng C, Evans WE, Relling MV, Pui CH, Infection-related complications during treatment for childhood acute lymphoblastic leukemia. Annals of Oncology 28:386-392, 2017.

Shenep MA, Tanner MR, Sun Y, Culley T, Hayden RT, Flynn PM, Tang L, Wolf J. Catheter-related complications in children with cancer who receive parenteral nutrition: Change in risk is moderated by catheter type. Journal of Parenteral and Enteral Nutrition 41:1063-107, 2017.

Ferguson-Paul K, Mangum S, Porter A, Leventaki V, Campbell P, Wolf J. Hemophagocytic lymphohistiocytosis and progressive disseminated histoplasmosis. Emerging Infectious Diseases 22:1119-1121, 2016.

Wolf J, Tang L, Rubnitz JE, Brennan RC, Shook DR, Stokes DC, Monagle P, Curtis N, Worth LJ, Allison KJ, Sun Y, Flynn PM. Monitoring central venous catheter resistance to predict imminent occlusion: A prospective pilot study. PLOS ONE 10:e0135904, 2015.

Wolf J. Antibiotic resistance threatens the efficacy of prophylaxis. The Lancet Infectious Diseases 15:1368-1369, 2015.

Wolf J, Sun Y, Tang L, Newland JG, Gerber JS, Van Dyke CJ, Hymes SR, Yu D, Carias DC, Bryant PA. Antimicrobial stewardship barriers and goals in pediatric oncology and bone marrow transplantation: A survey of antimicrobial stewardship practitioners. Infection Control and Hospital Epidemiology 37:343-347, 2015.

Wolf J, Allison KJ, Tang L, Sun Y, Hayden RT, Flynn PM. No evidence of benefit from antibiotic lock therapy in pediatric oncology patients with central line-related bloodstream infection: Results of a retrospective matched cohort study and review of the literature. Pediatric Blood and Cancer 61:1811-1815, 2014.

Carter R*, Wolf J*, van Opijnen T*, Muller M, Obert C, Burnham C, Mann B, Li Y, Hayden RT, Pestina T, Persons D, Camilli A, Flynn PM, Tuomanen EI, Rosch JW. Genomic analysis of pneumococci from children with sickle cell disease reveals disease-specific bacterial adaptations and deficits in current clinical interventions. Cell Host & Microbe 15:587-599, 2014. *Equal contribution.

Cooley L, Dendle C, Wolf J, Teh BW, Chen SC, Boutlis C, Thursky KA. Consensus guidelines for diagnosis, prophylaxis and management of Pneumocystis jirovecii pneumonia in patients with haematological and solid malignancies. Internal Medicine Journal 44:1350-1363, 2014.

Wolf J, Curtis N. Wash your hands after playing with that dragon! Journal of Paediatrics and Child Health 50:1023-1024, 2014.

Wolf J, Curtis N, Worth LJ, Flynn PM. Central line-associated bloodstream infection in children: an update on treatment. Pediatric Infectious Diseases Journal 32:905-910, 2013.

Wolf J, Shenep JL, Clifford V, Curtis N, Flynn PM. Ethanol lock therapy in Pediatric Hematology and Oncology. Pediatric Blood and Cancer 60:18-25, 2013.

Wolf J, Daley AJ, Tilse MH, Nimmo GR, Bell S, Howell AJ, Keil AD, Lawrence A, Curtis N. Antibiotic susceptibility patterns of Staphylococcus aureus isolates from Australian Children. Journal of Paediatrics and Child Health 46:404-11, 2010.

Wolf J, South M. Image of the month: A swollen eye. Journal of Paediatrics and Child Health 46:203, 2010.

Wolf J, Slavin MA. Risk-based antifungal prophylaxis in patients with haematological malignancies.Current Reports in Infectious Diseases 11:420-6, 2009.

Nairn EK, Wolf J, Buttery JP. The hidden cost of varicella. Medical Journal of Australia 190:4, 2009.

Wolf J, Curtis N. Brain abscess secondary to dental braces. Pediatric Infectious Disease Journal 27:84, 2008.

Wolf J, Salo R. Water, water, everywhere, Nor any drop to drink: climate change delusion. Australian and New Zealand Journal of Psychiatry 42:350, 2008.

Wolf J, Daley A J. Microbiological aspects of bacterial lower respiratory tract illness in children: Atypical pathogens. Paediatric Respiratory Reviews 8:204-211, 2007.

Wolf J, Daley A J. Microbiological aspects of bacterial lower respiratory tract illness in children: Typical pathogens. Paediatric Respiratory Reviews 8:212-220, 2007.

Johnson DF, Druce JD, Chapman S, Swaminathan A, Wolf J, Richards JS, Korman T, Birch C, Richards MJ. Chikungunya virus infection in travellers to Australia. Medical Journal of Australia 188:41-43, 2008.

Wolf J, Curtis N, Buttery J et al. Liposomal amphotericin trial marred by conclusion. Clinical Infectious Diseases 45:667-668, 2007.

Bartlett J, Lee S, Mishina Y, Behringer R, Yang N, Wolf J, Temelcos C, Hutson J. Gubernacular development in Mullerian inhibiting substance receptor-deficient mice. BJU International 89(1), 2002.

Last update: July 2020

For updates on COVID-19, please read.