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Kristine Crews, PharmD, BCPS

Kristine Crews, PharmD, BCPS

  • Clinical Pharmacogenomics Residency Director
  • Co-director, Pharmacokinetics Shared Resource
  • Translational Research Laboratory Director

Departments

Education

BS - Rutgers, The State University of New Jersey, New Brunswick
PharmD - Rutgers, The State University of New Jersey, New Brunswick
Residency - Clinical Pharmacokinetics, University of Kentucky Medical Center, Lexington
Fellowship - Clinical Pharmacokinetics/Pharmacodynamics and Drug Development, University of North Carolina School of Pharmacy, Chapel Hill and Glaxo Wellcome, Inc., Research Triangle Park, North Carolina

Honors and Awards

  • 2014 Fellow, American College of Clinical Pharmacy
  • 2012 ASHP Research and Education Foundation Innovation in Pharmacy Practice Literature Award
  • 2012 Hematology Oncology Pharmacy Association Oncology Pharmacy Practice Literature Award

Research Interests

  • Clinical pharmacokinetics and pharmacodynamics of anticancer drugs in children
  • Clinical implementation of pharmacogenomics to individualize treatment regimens

Selected Publications

Ferguson DC, McCorkle JR, Barnett KR, Bonten EJ, Bergeron BP, Bhattarai KR, Yang W, Smith C, Hansen BS, Bajpai R, Dong Q, Autry RJ, Gocho Y, Diedrich JD, Crews KR, Pruett-Miller SM, Roberts KG, Stock W, Mullighan CG, Inaba H, Jeha S, Pui CH, Yang JJ, Relling MV, Evans WE, Savic D. Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia. Blood Adv Jun 14;6(11):3386-3397, 2022. PMID: 35671062

Finch ER, Janke LJ, Lie L, Payton MA, Jenkins DA, Crews KR, Relling MV, Karol SE. Dasatinib does not exacerbate dexamethasone-induced osteonecrosis in murine models of acute lymphoblastic leukemia therapy. Pediatr Blood Cancer Apr;69(4):e29490, 2022. PMID: 34866312

Morris SA, Crews KR, Hayden RT, Takemoto CM, Yang W, Baker DK, Broeckel U, Relling MV, Haidar CE. Incorporating genotyping to identify patients with G6PD deficiency. Pharmacogenetics and Genomics Apr 1;32(3):87-93, 2022. PMID: 34693927

Gocho Y, Liu J, Hu J, Yang W, Dharia NV, Zhang J, Shi H, Du G, John A, Lin TN, Hunt J, Huang X, Ju B, Rowland L, Shi L, Maxwell D, Smart B, Crews KR, Yang W, Hagiwara K, Zhang Y, Roberts K, Wang H, Jabbour E, Stock W, Eisfelder B, Paietta E, Newman S, Roti G, Litzow M, Easton J, Zhang J, Peng J, Chi H, Pounds S, Relling MV, Inaba H, Zhu X, Kornblau S, Pui CH, Konoplova M, Teachey D, Mullighan CM, Stegmaier K, Evans WE, Yu J, Yang JJ. Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia. Nat Cancer Mar;2(3):284-299, 2021. PMID: 34151288

Sauer HE, Crews KR, Pauley JL, Bourque MS, Bragg AW, Triplett B, Morrison RR, Hall EA. Evaluation of aminophylline for the treatment of acute kidney injury in pediatric hematology/oncology patients. J Pediatr Pharm Ther 26(5):484-490, 2021. PMID: 34239401

Giacomini K, Karnes JH, Crews KR, Monte AA, Murphy WA, Oni-Orisan A, Ramsey LB, Yang JJ, Whirl-Carrillo M. Advancing precision medicine through the new Pharmacogenomics Global Research Network. Clin Pharmacol Ther 110:559-62, 2021. PMID: 34318925

Karol SE, Pei D, Smith CA, Liu Y, Yang W, Kornegay NM, Panetta JC, Crews KR, Cheng C, Finch ER, Inaba H, Metzger ML, Rubnitz JE, Ribeiro RC, Gruber TA, Yang JJ, Evans WE, Jeha S, Pui CH, Relling MV. Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy. Haematologica 107(2):371-380, 2022. PMID: 34196166

Montefiori LE, Bendig S, Gu Z, Chen X, Polonen P, Ma X, Murison A, Zeng A, Garcia-Prat L, Dickerson K, Iacobucci I, Abdelhamed S, Hiltenbrand R, Mead PE, Mehr CM, Xu B, Cheng Z, Chang TC, Westover T, Ma J, Stengel A, Kimura S, Qu C, Valentine MB, Rashkovan M, Luger S, Litzow MR, Rowe JM, den Boer ML, Wang V, Yin J, Kornblau SM, Hunger SP, Loh ML, Pui CH, Yang W, Crews KR, Roberts KG, Yang JJ, Relling MV, Evans WE, Stock W, Paietta EM, Ferrando AA, Zhang J, Kern W, Haferlach T, Wu G, Dick JE, Klco JM, Haferlach C, Mullighan CG. Enhancer hijacking drives oncogenic BCL11B expression in lineage ambiguous stem cell leukemia. Cancer Discov 11:2846-67, 2021. PMID: 34103329

Diouf B, Wing C, Panetta JC, Eddins D, Lin W, Yang W, Fan Y, Pei D, Cheng C, Delaney SM, Zhang W, Bonten EJ, Crews KR, Paugh SW, Li L, Freeman BB, Autry RJ, Beard JA, Ferguson DC, Janke LJ, Ness KK, Chen T, Zakharenko SS, Jeha S, Pui CH, Relling MV, Dolan ME, Evans WE. Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemic cells to vincristine. Clin Transl Sci 14:1490-1504, 2021. PMID: 33742760

Diedrich JD, Dong Q, Ferguson D, Bergeron B, Autry RJ, Qian M, Yang W, Smith C, Papizan JB, Hagiwara K, Crews KR, Pruett-Miller SM, Pui CH, Yang JJ, Relling MV, Evans WE, Savic D. Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks. Leukemia 35:3078-91, 2021. PMID: 33714976

Jeha S, Crews KR, Pei D, Peyton M, Panetta JC, Ribeiro RC, Zhao X, Campbell P, Metzger ML, Yang JJ, Cheng C, Pui CH, Bhojwani D. Phase I study of bendamustine in combination with clofarabine, etoposide, and dexamethasone in pediatric patients with relapsed or refractory hematologic malignancies. Cancer 127:2074-82, 2021. PMID: 33598942

Crews KR, Monte AA, Huddart R, Caudle KE, Kharasch ED, Gaedigk A, Dunnenberger HM, Leeder JS, Callaghan JT, Samer CF, Klein TE, Haidar CE, Van Driest SL, Ruano G, Sangkuhl K, Cavallari LH, Muller DJ,  Prows CA, Nagy M, Somogyi AA, Skaar TC. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, OPRM1, and COMT genotypes and select opioid therapy. Clin Pharmacol Ther 110:888-96, 2021. PMID: 33387367

Jiang C, Yang W, Moriyama T, Liu C, Smith C, Yang W, Qian M, Li Z, Tulstrup M, Schmieglow K, Crews KR, Zhang H, Pui CH, Evans WE, Relling MV, Bhatia S, Yang JJ. Effects of NT5C2 germline variants on 6-mecaptopurine metabolism in children with acute lymphoblastic leukemia. Clin Pharmacol Ther 109:1538-1545, 2021. PMID: 33124053

Lopez-Lopez E, Autry RJ, Smith C, Yang W, Paugh SW, Panetta JC, Crews KR, Bonten EJ, Smart B, Pei D, McCorkle JR, Diouf B, Roberts KG, Shi L, Pounds S, Cheng C, Mullighan CG, Pui CH, Relling MV, Evans WE. Pharmacogenomics of intracellular methotrexate polyglutamates in patients’ leukemia cells in vivo. J Clin Invest 130:6600-15, 2020. PMCID: PMC7685728

Autry RJ, Paugh SW, Carter RA, Shi L, Liu J, Ferguson DC, Lau CE, Bonten EJ, Yang W, McCorkle JR, Beard JA, Panetta JC, Diedrich JD, Crews KR, Pei D, Coke CJ, Natarajan S, Khatamian A, Karol SE, Lopez-Lopez E, Diouf B, Smith C, Roberts KG, Pounds S, Kornblau SM, Mullighan CG, Jeha S, Pui CH, Cheng C, Yang JJ, Savic D, Yu J, Gawad C, Relling MV, Evans WE. Integrative genomic analyses reveal known and novel mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia. Nature Cancer 1:329-44, 2020. PMCID: PMC7467080

Karol SE, Cooper TM, Mead PE, Crews KR, Panetta JC, Alexander TB, Taub JW, Lacayo NJ, Heym KM, Kuo DJ, Schiff DE, Bhojwani D, Ge Y, Klco JM, Ribeiro RC, Inaba H, Pui CH, Rubnitz JE. Safety, pharmacokinetics, and pharmacodynamics of panobinostat in children, adolescents and young adults with relapsed acute myeloid leukemia. Cancer 126:4800-5, 2020. PMCID: PMC7722063

Finch ER, Smith CA, Yang W, Kornegay NM, Panetta JC, Crews KR, Molinelli AR, Cheng C, Pei D, Ramsey LB, Karol SE, Inaba H, Sandlund JT, Metzer M, Evans WE, Jeha S, Pui CH, Relling MV. Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia. Pediatr Blood Cancer 67: e28040, 2020. PMCID: PMC6868303

Hoshitsuki K, Crews KR, Yan W, Smith CA, Hankins JS, Turner AJ, Broeckel U, McMillin GA, Relling MV, Haidar CE. Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination. Genet Med 22: 232-3, 2020. PMID: 31341243

Liu Y, Smith CA, Panetta JC, Yang W, Thompson LE, Counts JP, Molinelli A, Pei D, Kornegay NM, Crews KR, Swanson H, Cheng C, Karol SE, Evans WE, Inaba H, Pui CH, Jeha S, Relling, MV. Antibodies predict pegaspargase allergic reactions and failure of rechallenge. J Clin Oncol 37: 2015-61, 2019. PMCID: PMC6804844

Pasternak AL, Crews KR, Caudle KE, Smith C, Pei D, Cheng C, Broeckel U, Gaur A, Relling MV, Haidar CE. An analysis of the impact of the UGT1A1 *60 allele on bilirubin serum concentrations. Pharmacogenomics 18:5-16, 2017.

Stock W, Diouf B, Crews KR, Pei D, Cheng C, Laumann K, Mandrekar SJ, Luger S, Advani A, Stone RM, Larson RA, Evans WE. An inherited genetic variant in CEP72 promoter predisposes to vincristine-induced peripheral neuropathy in adults with acute lymphoblastic leukemia. Clin Pharmacol Ther 101:391-5, 2017.

Gammal RS, Crews KR, Haidar CE, Hoffman JM, Baker DK, Barker PJ, Estepp JH, Pei D, Broeckel U, Wang W, Weiss MJ, Relling MV, Hankins JS. Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease. Pediatrics 138:e20153479, 2016.

Diouf B, Crews KR, Lew G, Pei D, Cheng C, Bao J, Zheng JJ, Yang W, Fan Y, Wheeler HE, Wing C, Delaney SM, Komatsu M, Paugh SW, McCorkle JR, Lu X, Winick NJ, Carroll WL, Loh ML, Hunger SP, Devidas M, Pui CH, Dolan ME, Relling MV, Evans WE. Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia. JAMA 313:815-23, 2015.

Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RKS, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, , McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, Fernandez CA, Diouf B, Smith C, Hicks JK, Zanut A, Giordanengo A, Crona D, Bianchi JJ, Holmfeldt L, Mullighan CG, den Boer ML, Pieters R, Jeha S, Dunwell TL, Latif F, Bhojwani D, Carroll WL, Pui CH, Myers RM, Guy RK, Kanneganti T, Relling MV, Evans WE. NALP3 inflammasone upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nat Genet 47:607-14, 2015.

Scott JR, Zhou Y, Cheng C, Ward DA, Swanson HD, Molinelli AR, Stewart CF, Navid F, Jeha S, Relling MV, Crews KR. Comparable efficacy with varying dosages of glucarpidase in pediatric oncology patients. Pediatr Blood Cancer 62:1518-22, 2015.

Yang JJ, Landier W, Yang W, Liu C, Hageman L, Cheng C, Pei D, Chen Y, Crews KR, Kornegay N, Wong FL, Evans WE, Pui CH, Bhatia S, Relling MV. Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia. J Clin Oncol 33:1235-42, 2015.

Dunnenberger HM, Crews KR, Hoffman JM, Caudle KE, Broeckel U, Howard SC, Hunkler RJ, Klein TE, Evans WE, Relling MV. Preemptive clinical pharmacogenetics implementation: Current programs in five US medical centers. Ann Rev Pharmacol Toxicol 55:89-106, 2015.

Caudle KE, Klein TE, Hoffman JM, Muller DJ, Whirl-Carrillo M, McDonagh EM, Sangkuhl K, Thorn CF, Schwab M, Agundez JAG, Freimuth RR, Huser V, Lee MTM, Iwuchukwu OF, Crews KR, Scott SA, Wadelius M, Swen JJ, Stein CM, Roden D, Relling MV, Williams MS, Johnson SG. Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process. Curr Drug Metab 15:209-17, 2014.

Scott JR, Ward DA, Crews KR, Panetta JC, Relling MV, Navid F. Hypersensitivity reaction to high-dose methotrexate and successful rechallenge in a pediatric patients with osteosarcoma. Pediatr Blood Cancer 61:373-5, 2014.

Pauley JL, Panetta JC, Crews KR, Pei D, Cheng C, McCormick J, Howard SC, Sandlund JT, Jeha S, Ribeiro RC, Rubnitz JE, Pui CH, Evans WE, Relling MV. Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments. Cancer Chemother Pharmacol 72:369-78, 2013.

Last update: December 2022

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