Pharmaceutical Department Residency Programs

Clinical Pharmacogenomics


St. Jude Children’s Research Hospital offers a 12-month ASHP-accredited specialized (PGY2) Residency in Clinical Pharmacogenomics. 

This program prepares residents to excel in implementing pharmacogenomic testing in clinical practice. The institution’s full integration of an electronic medical record that applies to inpatient and outpatient care, the comprehensive translational research programs, the highly skilled clinical pharmacy specialist team, and the strong laboratory component to the Pharmaceutical Department provides unmatched opportunities for clinical use of pharmacogenetics into patient care. 

The resident will learn, contribute and participate in a dynamic environment with world experts translating laboratory-based discoveries into comprehensive medication management for multiple disease states.

St. Jude runs an institution-wide program to implement pre-emptive pharmacogenomic testing (PG4KDS). The resident will assist in directing the PG4KDS program and provide pharmacogenomic consults in the context of a comprehensive approach to pharmaceutical care integrated into the clinical practice areas: general hematology/oncology and bone marrow transplantation. Training will be provided in applied pharmacokinetics, infectious diseases, nutrition support, clinical informatics, and advanced pediatric pharmacotherapy. The resident will work with established clinicians on interdisciplinary teams to deliver personalized pharmacotherapy to pediatric patients with catastrophic diseases.


The resident will design safe and effective patient-centered therapeutic regimens and monitoring plans. In addition, he or she will build pharmacogenomic clinical consults and help develop customized pharmacogenomic clinical decision-support alerts that will alert clinicians of high-risk gene-drug pairs and allow for genetically guided drug dosing. The resident will be expected to write a manuscript for publication and participate in patient education, drug information, quality improvement and medication-outcomes activities.

Residents are highly involved in international efforts to implement pharmacogenomics on a broad scale via participation in the Clinical Pharmacogenetics Implementation Consortium (CPIC). Upon completion of the program, the resident will have the clinical and leadership skills as well as the necessary experience to manage a clinical pharmacogenomics practice, and to implement pharmacogenomic testing in other health-system settings.

Clinical Pharmacogenomics residents learn, contribute and participate in a dynamic environment that consists of professional and technical personnel in both patient care and pharmaceutical research. Along with direct patient care responsibilities, residents will have the opportunity to gain experience in teaching through lectures, in-services, journal club presentations and precepting pharmacy students. A teaching certificate is offered by the University of Tennessee College of Pharmacy. An independent research project will be carried out during the residency, with a presentation of the findings at a national meeting.


Longitudinal Experiences

Research project

The research project will be designed and carried out by the resident to answer a clinically relevant question in the field of pharmacogenomics. The project may encompass one of the following areas: laboratory performance characteristics of genotyping techniques, creation of automated pharmacogenomic consults and alerts in the medical record, defining a phenotype for a novel observed diplotype, clinician actions based on point-of-care pharmacogenomic alerts, patient acceptance of pharmacogenomic information or generalizability to other clinical settings.  The resident will use effective written and oral communication to disseminate the research findings.

Educational & Teaching

Throughout the year, the Clinical Pharmacogenomics resident will provide didactic lectures to pharmacy students and in-services to clinicians on implementation of pharmacogenomics in the clinic. In addition, the resident will present at journal clubs and may participate in the Pharmacogenetics Oversight Committee and other institutional meetings  The resident will meet on a routine basis with the preceptor for the purposes of discussing performance and addressing goals and objectives relating to improving quality of one’s own performance through self-assessment and personal development

Professionalism & Leadership

This longitudinal learning experience is designed to assure that goals and objectives related to professionalism and leadership are addressed during the program.  In addition, the experience is intended to confirm that residents are routinely informed of organizational practice and other issues that may impact pharmacy practice.  Residents will also have scheduled access to the senior leader of the department.  Residents will meet on a routine basis with the Chief Pharmaceutical Officer for the purpose of discussing and addressing goals and objectives and other relevant professional and organizational issues. 


Number of Positions


Start Date

July 1

Application Deadline

Fist Monday of January by 11:59 p.m. CST

Learn How to Apply to the Clinical Pharmacogenomics Residency >


Program Director

Kristine R. Crews, PharmD, FCCP, BCPS

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