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Elisabeth E. Adderson, MD
Elisabeth E. Adderson, MD

Elisabeth E. Adderson, MD

Associate Member, St. Jude Faculty

  • Director, Pediatric Infectious Diseases Fellowship Program



MD – University of Alberta, Canada

Research Interests

  • Epidemiology and therapy of infections in the immunocompromised host
  • Pathogenesis of infections caused by encapsulated bacteria
  • Evidence-based medicine

Characterization of novel virulence factors for encapsulated bacterial pathogens

Selected Publications

Cortez V, Freiden P, Gu Z, Adderson EE, Hayden R, Schultz-Cherry S. Persistent infectious with diverse co-circulating astroviruses in pediatric oncology patients, Memphis, Tennessee USA. Emerg Inf Dis 2017 (in press).

Mhaissen MN, Rodriguez A, Gu Z, Zhu H, Tang L, Sun Y, Schultz-Cherry S, Hayden RT, Adderson EE. Epidemiology of diarrheal disease in pediatric oncology patients. J Pediatr Inf Dis Soc 2017 (in press).

Naeem F, Metzger ML, Arnold SR, Adderson EE. Distinguishing benign mediastinal masses from malignancy in a histoplasmosis-endemic region. J Pediatr 4:104-13, 2015. PMC460849

Gu Z, Rodriguez A, Mhaissen M, Schultz-Cherry S, Adderson EE, Hayden RT. Comparative evaluation of broad-panel PCR assays for the detection of gastrointestinal pathogens in pediatric oncology patients. J Mol Diagn 17:715-21, 2015.

McCarville MB, Chen J, Coleman J, Li Y, Li X, Adderson E, Neel M, Gold R, Kaufman R. Distinguishing osteomyelitis from Ewing sarcoma. Amer J Roentol 205:640-51, 2015.

Ojha RP, Stallings-Smith S, Flynn PM Adderson E, Offutt-Powell TN, Gaur AH. The impact of vaccine concerns on racial/ethnic disparities in influenza vaccine uptake among healthcare workers. Amer J Public Health 105:e35-41, 2015.

Apiwattanakul N, Flynn PM, Hayden RT, Adderson EE. Infections caused by rapidly growing Mycobacteria spp in children and adolescents with cancer. J Pediatr Infect Dis Soc 4;104-13, 2015.

Adderson E, Gaur A, Flynn PM, Branum K, Sealy RE, Jones BG, Surman SL, Pendert R, Freiden P, Slobod KS, Hayden R, Allison K, Nowlett N, Utech J, Allay J, Knight J, Sleep S, Meagher M, Russell C, Portner A, Hurwitz JL. Safety and immunogenicity of an intranasal parainfluenza type 1 vaccine (SeV) in 3-6 year old children. Clin Vaccine Immunol 22:298-303, 2015. PMC4340902

Donovan ST, Thompson JT, Sandlund JT, Adderson EE, Pivnick EK, Harreld JH. Imaging of acute invasive fungal rhinosinusitis in a patient with Gorlin syndrome. Case Rep Otolaryngol 2013:272314, 2013. PMC3703339

Hoffman JM, Frediani J, Herr M, Flynn PM, Adderson EE. Safety of cefepime and ceftazidime in pediatric oncology patients. Pediatr Blood Cancer 60:806-9, 2013.

Carr SB, Adderson EE, Hakim H, Xiong X, Yan X, Caniza M. Clinical and demographic characteristics of seasonal influenza in pediatric patients with cancer. Pediatr Infect Dis J July 5, 2012.

Carr S, Allison KJ, Van De Velde LA, Zhang K, English EY, Iverson A, Daw NC, Howard SC, Navid F, Rodriguez-Galindo C, Yang J, Adderson EE, McCullers JA, Flynn PM. Safety and immunogenicity of live attenuated and inactivated influenza vaccines in children with cancer. J Inf Dis 204(10):1475-1482, 2011.

Chattopadhyay D, Carey AJ, Caliot E, Webb RI, Layton JR, Wang Y, Bohnsack JF, Adderson EE, Ulett GC. Phylogenetic lineage and pilus protein Spb1/SAN1518 affect opsonin-independent phagocytosis and intracellular survival of Group B Streptococcus. Microbes Infect 13(4):369-82, 2011.

Sejvar JJ, Kohl KS, Gidudu J, Amato A, Bakshi N, Baxter R, Burwen DR, Cornblath DR, Cleerbout J, Edwards KM, Heininger U, Hughes R, Khuri-Bulos N, Korinthenberg R, Law BJ, Munro U, Maltezou HC, Nell P, Oleske J, Sparks R, Velentgas P, Vermeer P, Wiznitzer M, Brighton Collaboration GBS Working Group. Guillain–Barré syndrome and Fisher syndrome: Case definitions and guidelines for collection, analysis, and presentation of immunization safety data. Vaccine 29(3):599-612, 2011.

Adderson EE, Flynn PM, Hoffman JM. Efficacy and safety of cefepime in pediatric patients: a systematic review and meta-analysis. J Pediatr 157(3):490-5, 2010.

Maron GM, Clara AW, Diddle JW, Pleites EB, Miller L, Macdonald G, Adderson EE. Association between nutritional status and severity of dengue infection in children in El Salvador. Am J Trop Med Hyg 82(2):324-9, 2010.

Adderson EE, Boudreau JW, Hayden RT. Infections caused by coryneform bacteria in pediatric oncology patients. Pediatr Inf Dis J 27:136-141, 2008.

Aoyagi Y, Adderson EE, Rubens CE, Bohnsack JF, Min JG, Matsushita M, Fujita T, Okuwaki Y, Takahashi S. L-ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway. Infect Immun 76(1):179-188, 2007.

Byington CL, Bender JM, Ampofo K, Pavia AT, Korgenski K, Daly J, Christenson JC, Adderson EE. Tularemia with vesicular skin lesions may be mistaken for infection with herpesviruses. Clin Inf Dis 1;47:e4-6, 2008.

Adderson EE, Boudreaux JW, Pounds S, Hayden RT. Identification of Clinical Coryneform Bacterial Isolates: A Comparison of Biochemical Methods and Sequence Analysis of 16S rRNA and rpoB. J Clin Microbiol 46:921-7, 2007.

Aoyagi Y, Adderson EE, Rubens CE, Matsushita M, Fujita T, Takahashi S, Okuwaki Y, Bohnsack JF.L-ficolin/Mannose-Binding Lectin-Associated Serine Protease Complexes Bind to Group B Streptococci Largely through N-Acetylneuraminic Acid of Capsular Polysaccharide, and Activate the Complement Pathway. Infect Immun 76:179-88, 2008.

Avanhanula V, Wang Y, Krishnamurthy S, Allen Portner A, Adderson EE. Nontypeable Haemophilus influenzae and Streptococcus pneumoniae bind respiratory syncytial virus glycoprotein. J Med Microbiol 56:1133-7, 2007.

Ohuoba EF, Kansal RG, Hayden RT, Shenep J, Kotb M, Adderson EE. Failure of viridans group streptococci causing bacteremia in pediatric oncology patients to express superantigens. J Pediatr Hematol Oncol 28:627-629, 2006.

Lin F-YC, Whiting A, Adderson EE, Takahashi S, Dunn DM, Weiss R, Weisman LE, Azimi PH, Philips III JB, Clark P, Regan J, Rhoads GG, Frasch CE, Troendle J, Moyer P, Bohnsack JF. Phylogenetic lineages of invasive and colonizing strains of serotype III Group B Streptococci from neonates – A multi-center prospective study. J Clin Microbiol 44:1257-61, 2006.

Seifert KN, Adderson EE, Whiting A, Bohnsack JF, Brady LJ. A unique serine-rich repeat protein (Srr-2) and novel surface antigen (epsilon) associated with a virulent lineage of serotype III Streptococcus agalactiae. Microbiology 152:1029-40, 2006.

Avadhanula V,Rodriguez CA,DeVincenzo JP,Wang Y,Webby RJ,  Ulett GC, Adderson EE. Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species and cell type-dependent manner. J Virol 80: 1629-1636, 2006.

Ulett GC, Adderson EE. Regulation of apoptosis by gram-positive bacteria: Mechanistic diversity and consequences for immunity. Curr Rev Immunol 2:119-141, 2006.

Adderson EE. Histoplasmosis. Pediatr Inf Dis J 25:73-74, 2006.

Avadhanula V, Rodriguez CA, Ulett GC, Bakeletz LO, Adderson EE. Nontypeable Haemophilus influenzae adhere to ICAM-1 on respiratory epithelial cells and upregulate ICAM-1 expression. Infect Immun 74:830-838, 2006.

Show More

Adderson EE. Streptococcal-induced apoptosis of macrophages. Mod Asp Immunobiol 16:7, 2005.

Ulett GC, MacLean KH, Nekkalapu S, Cleveland JC, Adderson EE. Mechanisms of group B streptococcal-Induced apoptosis of murine macrophages. J Immunol 175:2555-62, 2005.

Gaur AH, Knapp KM, Daw NC, Rao BN, Rodriguez-Galindo C, Brand D, Adderson EE. Infections in patients with bone malignancies undergoing limb-sparing surgery. Cancer 104:602-10, 2005.

Ulett GC, Adderson EE. Nitric oxide is a key determinant of group B streptococcal-induced macrophage apoptosis. J Inf Dis 191:1761-1770, 2005.

Aoyage Y, Adderson EE, Matsushita M, Fujita T, Takahashi S, Yoshiyuki O, Bohnsack JF. Role of L-ficolin/MASP complexes in the opsonophagocytosis of type III group B streptococci. J Immunol 174:418-425, 2005.

Sandlund JT, Howard SC, Hijiya N, Pui C-H, Shenep JL, Adderson EE. Myositis complicating viridans streptococcal sepsis in childhood leukemia. Pediatr Blood Cancer 44:1-3, 2005.

Bohnsack JF, Martinez G, Jones N, Adderson EE, Detrick S, Whiting AA, Blaschke-Bonkowksy AJ, Gottschalk M. Serotype III Streptococcus agalactiae isolated from bovine milk and human neonatal infections. Emerg Inf Dis 10:1412-1419, 2004.

Fleming KE, Bohnsack JF, Palacios GC, Takahashi S, Adderson EE. Equivalence of high virulence clonotypes of serotype III group B Streptococcus agalactiae. J Med Micro 53:505-508, 2004.

Adderson EE. Histoplasmosis in a pediatric oncology center. J Pediatr 144:100-106, 2004.

Adderson EE, Takahashi S, Wang Y, Armstrong J, Miller DV, Bohnsack JF. Subtractive hybridization identifies a novel predicted protein mediating epithelial cell invasion by virulent serotype III Group B Streptococcus agalactiae. Infect Immun 71:6857-63, 2003.

Ulett GC, Bohnsack JF, Armstrong J, Adderson EE. Apoptosis of macrophages infected with serotype II Group B Streptococcus is induced independently of ß-hemolysin. J Inf Dis 188:1049-53, 2003.

O’Neill JM, St. Geme III JW, Cutter D, Adderson EE, Anyanwu J, Jacobs RF, Schutze GE. J Invasive nontypable Haemophilus influenzae disease in Arkansas. Clin Micro 41:3064-3069, 2003.

Anyanwu J, Rodriguez CA, Adderson EE. pgi genotyping as a surrogate for serotyping of encapsulated Haemophilus influenzae. J Clin Micro 41:2080-2083, 2003.

Rodriguez CA, Avadhanula V, Buscher AZ, St. Geme III JW, Smith AL, Adderson EE. Prevalence and distribution of adhesin genes in invasive non-type b encapsulated Haemophilus influenzae. Infect Immun 71:1635-1642, 2003.

Rodriguez CA, Luj n-Zilbermann J, Woodard P, Andreansky M, Adderson EE. Successful treatment of disseminated fusariosis. Bone Marrow Transplant 35:311-312, 2003.

Takahashi S, Detrick S, Whiting AA, Blaschke-Bonkowksy AJ, Aoyagi Y, Adderson EE, Bohnsack JF. Correlation of Phylogenetic Lineages of Group B Streptococci Identified by Analysis of Restriction Digest Patterns of Genomic DNA with infB Alleles and Mobile Genetic Elements. J Inf Dis 186:1034-1038, 2002.

Takahashi S, Omikunle A, Ogilvie CL, Rodriguez CA, St. Geme III JW, Adderson EE. Limited genetic diversity of recent invasive isolates of non-serotype b encapsulated Haemophilus influenzae. J Clin Micro 40:1264-1270, 2002.

Last update: March 2017