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Rebecca Epperly, MD
Rebecca Epperly, MD

Rebecca Epperly, MD

Assistant Member, St. Jude Faculty



BS (Biochemistry) - University of Iowa, Iowa City, IA         
BA (Music) - University of Iowa, Iowa City, IA
MD - University of Iowa, Carver College of Medicine, Iowa City, IA
Residency (Pediatrics) - UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA
Fellowship (Pediatric Hematology/Oncology) – St. Jude Children’s Research Hospital, Memphis, TN
Fellowship (Pediatric Bone Marrow Transplant/Cellular Therapy) - St. Jude Children’s Research Hospital, Memphis, TN
MS (Clinical Investigations) - St. Jude Graduate School of Biomedical Sciences, Memphis, TN

Research Interests

  • Clinical evaluation of cellular immunotherapies
  • Expanding application of chimeric antigen receptor (CAR) T cell therapy for pediatric cancers

Selected Publications

Epperly R, Talleur AC, Li Y, Schell S, Tuggle M, Métais JY, Huang S, Pei D, Cheng C, Madden R, Mamcarz E, Naik S, Qudeimat A, Sharma A, Srinivasan A, Suliman A, Gottschalk S, Triplett BM. Sub-myeloablative second transplantations with haploidentical donors and post-transplant cyclophosphamide have limited anti-leukemic effects in pediatric patients. Transplant Cell Ther May 1;28(5):262.e1-262.e10, 2022.

Maron GM, Hijano DR, Epperly R, Su Y, Tang L, Hayden RT, Naik S, Karol SE, Gottschalk S, Triplett BM, Talleur AC. Infectious complications in pediatric, adolescent and young adult patients undergoing CD19-CAR T cell therapy. Front Oncol Mar 9;12:845540, 2022.

Hebbar N, Epperly R, Vaidya A, Thanekar U, Moore SE, Umeda M, Ma J, Patil SL, Langfitt D, Huang S, Cheng C, Klco JM, Gottschalk S, Velasquez MP. CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells. Nat Commun Jan 31;13(1):587, 2022.

Epperly R, Santiago T, Morin C, Patton K, Deyo J, Eshun J, Triplett B, Sharma A. Targeting plasma cells with daratumumab aids in the treatment of post-transplant autoimmune-like hepatitis. Pediatr Blood Cancer Aug;e29290, 2021. doi: 10.1002/pbc.29290

Epperly R, Gottschalk S, Velasquez MP. Harnessing T cells to target pediatric acute myeloid leukemia: CARs, BiTEs, and beyond. Children Feb;7(2), 2020. doi: 10.3390/children7020014

Epperly R, Gottschalk S, Velasquez MP. A bump in the road: How the hostile AML microenvironment affects CAR T cell therapy. Front Oncol Feb;10:262, 2020. doi: 10.3389/fonc.2020.00262

Epperly R, Furman W, Hines M, Santiago T, Li Y, Madden R, Mamcarz E, Cervi D, Federico S, Triplett B, Talleur A. Secondary hemophagocytic syndrome after autologous hematopoietic cell transplant and immune therapy for neuroblastoma. Pediatr Blood Cancer Aug;e27964, 2019. doi: 10.1002/pbc.27964

Close A, Sequeira G, Montano G, Alessi L, McCormick M, Cooper J, Epperly R, Zuckerbraun N. Improving the evaluation and management of abnormal uterine bleeding in female adolescents presenting for emergency care. Pediatr Adolesc Gynecol Apr;32(2):128-134, 2019. doi: 10.1016/j.jpag.2018.11.002

Epperly R, Ozolek J, Soltys K, Cohen D, Goyal R, Friehling E. Treatment of pediatric plasma cell myeloma type post-transplant lymphoproliferative disorder with modern risk-directed therapy. Pediatr Blood Cancer Oct;65(10):e27283, 2018. doi: 10.1002/pbc.2728

Last update: May 2022