MS – National Taiwan University, Taipei, Taiwan
PhD – University of Michigan, Ann Arbor, Michigan
Postdoctoral Fellowship – Memorial Sloan-Kettering Cancer Center, New York
The long-term goal of my research is to develop novel radiation therapy methods and apply new technology to minimize normal tissue toxicity while improving tumor control for pediatric malignancy. First, long-term follow up data for patients with brain tumors and solid tumors after radiotherapy will provide valuable information to identify radiation dose-volume thresholds, establishing clinical constraints for treatment planning, and predicting the likelihood and severity of normal tissue toxicity for individual patients. Second, the application of intensity-modulated radiation therapy and proton beam in pediatric radiotherapy will further improve the distribution of dose and reduce normal tissue irradiation. Third, functional and physiological image-guided tumor extent delineation and identification of high tumor burden subvolumes with PET and MRI will facilitate more precise tumor targeting and normal tissue sparing. Combined with immobilization and localization specifically designed for pediatric patients, highly conformal radiotherapy can be safely and precisely delivered.
Hua C, Shapira N, Merchant TE, Klahr P, Yagil Y. Accuracy of electron density, effective atomic number, and iodine concentration determination with a dual-layer dual-energy computed tomography system. Med Phys 2018 (in press).
Breneman JC, Donaldson SS, Constine L, Merchant TE, Marcus K, Paulino A, Followill D, Mahajan A, Laack N, Esiashvili N, Daphne Haas-Kogan D, aurie F, Olch A, Ulin K, Hodgson D, Yock TI, Terezakis S, Krasin M, Panoff J, Chuba P, Hua C, Hess CB, Houghton PJ, Wolden S, Buchsbaum J, Fitzgerald TJ, Kalapurakal JA. The Children’s Oncology Group Radiation Oncology Discipline: 15 years of contribution to the treatment of childhood cancer. Int Radiat Oncol Biol Phys 2018 (In press).
Yao W, Moskvin V, Zhao L, Lukose R, Hua, C, Tsiamas P, Axentem M, Merchant T, Farr J. Implementation of a simplified analytical random walk model dose calculation algorithm with nuclear interaction for clinical scenarios in a proton pencil-beam scanning system. Biomed Phys Eng Express 2018 (in press).
Olch A and Hua C. Basic principles and advances in technology used for pediatric radiotherapy. In Merchant TE and Rolf-Dieter K (Eds.), Pediatric Radiation Oncology. Springer International Publishing, 2018.
Hsu CY, Doubrovin M, Hua C, Mohammed O, Shulkin BL, Kaste S, Federico S, Metzger M, Krasin MJ, Tinkle CL, Merchant TE, Lucas JT Jr. Radiomics features differentiate between normal and tumoral high-FDG uptake. Scientific Reports 8:3913, 2018.
Hua C, Uh J, Krasin MJ, Lucas Jr JT, Tinkle CL, Acharya S, Smith H, Kadbi M, Merchant T. Clinical implementation of magnetic resonance imaging systems for simulation and planning of pediatric radiation therapy. J Med Imag Radiat Sci 2018 (in press).
Uh J, Krasin MJ, Hua C. Technical Note: Feasibility of MRI-based estimation of water-equivalent path length to detect changes in proton range during treatment courses. Med Phys 2018 (in press).
Landry G, Hua C. Current state and future applications of radiological image guidance for particle therapy. Med Phys 2018 (in press).
De Blasi B, Barnes A, Galazzo IB, Hua C, Shulkin B, Koepp M, Tisdall M. Age-specific 18F-FDG image processing pipelines and analysis are essential for individual mapping of seizure foci in paediatric patients with intractable epilepsy J Nucl Med 2018 (in press).
Hua C, Yao W, Kidani T, Tomida K, Ozawa S, Nishimura T, Fujisawa T, Shinagawa R, Merchant TE. A robotic C-arm cone beam CT system for image-guided proton therapy: design and performance. Br J Radiol 2017 (in press).
Tsang DS, Merchant TE, Merchant SE, Smith H, Yagil Y, Hua C. Estimating potential reduction in contrast dose with mono-energetic images synthesized from double-layer detector spectral CT. Br J Radiol 2017 (in press).
Tinkle CL, Fernandez-Pineda I, Sykes A, Lu Z, Hua C, Neel MD, Bahrami A, Shulkin BL, Kaste SC, Pappo A, Spunt SL, Krasin MJ. Non-Rhabdomyosarcoma soft tissue sarcoma (NRSTS) in pediatric and young adult patients: results from a prospective study using limited margin radiotherapy. Cancer 2017 [published online ahead of print Jul 31, 2017]. doi: 10.1002/cncr.30793
Lucas JT Jr, Knapp BJ, Uh J, Hua C, Merchant TE, Hwang SN, Patay Z, Broniscer A. Posttreatment DSC-MRI is predictive of early treatment failure in children with supratentorial high-grade glioma treated with erlotinib. Clin Neuroradiol 2017 [published online ahead of print Apr 5, 2017]. doi: 10.1007/s00062-017-0580-1.
Lucas Jr JT, Serrano N, Kim H, Li X, Snyder SE, Hwang S, Li Y, Hua C, Broniscer A, Merchant TE, Shulkin BL. 11C-Methionine positron emission tomography delineates non-contrast enhancing tumor regions at high risk for recurrence in pediatric high-grade glioma. J Neurooncol 132(1):163-170, 2017.
Uh J, Krasin MJ, Li Y, Li X, Tinkle CL, Lucas Jr JT, Merchant TE, Hua C. Quantification of pediatric abdominal organ motion with a 4-dimensional magnetic resonance imaging method. Int J Radiat Oncol Biol Phys 99(1):227-237, 2017.
Uh J, Khan MA, Hua C. Four-dimensional MRI using internal respiratory surrogate derived by dimensionality reduction. Phys Med Biol 61(21):7812-7832, 2016.
Bass JK, Hua C, Huang J, Onar A, Ness K, Jones S, White S, Shaum PB, Chang KW, Merchant TE. Hearing loss in patients who received cranial radiation therapy for childhood cancer. J Clin Oncol 34(11):1248-1255, 2016.
Hua C, Shulkin BL, Indelicato DJ, Li Y, Li X, Boop FA, Merchant TE. Postoperative cerebral glucose metabolism in pediatric craniopharyngioma patients receiving proton therapy. J Neurosurg Pediatr 16(5):567-573, 2015.
Uh J, Merchant TE, Li Y, Li X, Sabin ND, Indelicato DJ, Ogg RJ, Boop FA, Hua C. Effects of surgery and proton therapy on cerebral white matter of craniopharyngioma patients. Int J Radiat Oncol Biol Phys 93(1):64-71, 2015.
Hua C, Merchant TE, Li Y, Li X, Shulkin BL. Establishing age-associated normative ranges of cerebral 18F-FDG uptake ratio in children. J Nucl Med 56(4):575-579, 2015.
Uh J, Merchant TE, Li Y, Li X, Hua C. MRI-based treatment planning with pseudo CT generated through atlas registration. Med Phys 41(5):051711, 2014. doi: 10.1118/1.4873315.
Uh J, Merchant TE, Li Y, Feng T, Gajjar A, Ogg RJ, Hua C. Differences in Brainstem Fiber Tract Response to Radiation: A Longitudinal Diffusion Tensor Imaging Study. Int J Radiat Oncol Biol PhysJune 1;86(2):292-7, 2013. doi:10.1016/j.ijrobp.2013.01.028.
Laser B, Merchant TE, Indelicato D, Hua C, Shulkin B. Evaluation of children with craniopharyngioma using carbon-11 methionine PET prior to proton therapy. J Neuro Oncol 15(4):506-510, 2013.
Merchant TE, Kun LE, Hua C, Wu S, Xiong X, Sanford R, Boop F. Disease control after reduced volume conformal and intensity-modulated radiation therapy for childhood craniopharyngioma. Int J Radiat Oncol Biol Phys 85(4):e187-92. 2013.
Pai Panandiker AS, Beltran C, Gray JM, Hua C. Methods for image-guided and intensity-modulated radiation therapy in high-risk abdominal neuroblastoma. Pract Radiat Oncol 3(2):107-114, 2013.
Hua C, Wu S, Chemaitilly W, Lukose RC, Merchant TE. Predicting the probability of abnormal stimulated growth hormone response in children after radiotherapy for brain tumors. Int J Radiat Oncol Biol Phys Nov 15;84(4):990-5, 2012. doi: 10.1016/j.ijrobp.2012.01.049. Epub 2012 Apr 6.
Hua C, Merchant TE, Gajjar A, Broniscer A, Zhang Y, Li Y, Glenn GR, Kun LE, Ogg RJ. Brain tumor therapy-induced changes in normal-appearing brainstem measured with longitudinal diffusion tensor imaging. Int J Radiat Oncol Biol Phys Apr 1;82(5):2047-54, 2012. Epub 2011 Jun 12.
Pai Panandiker AS, Sharma S, Naik M, Wu S, Hua C, Beltran C, Krasin MJ, Merchant TE. Novel assessment of renal motion in children as measured via 4-dimensional computed tomography. Int J Radiat Oncol Biol Phys Apr 1;82(5):1771-6, 2012. Epub 2011 May 27.
Krasin MJ, Wiese KM, Spunt SL, Hua C, Daw N, Navid F, Davidoff AM, McGregor L, Merchant TE, Kun LE, McCrarey L, Hoth KA, Yan X, Xiong X. Jaw dysfunction related to pterygoid and masseter muscle dosimetry following radiation therapy in children and young adults with head and neck sarcomas. Int J Radiat Oncol Biol Phys Jan 1;82(1):355-60, 2012. Epub 2010 Nov 17.
Hua C, Hoth KA, Wu S, Kun LE, Metzger ML, Spunt SL, Xiong X, Krasin MJ. Incidence and correlates of radiation pneumonitis in pediatric patients with partial lung irradiation. Int J Radiat Oncol Biol Phys78(1):143-9, 2010.
Krasin MJ, Davidoff AM, Xiong X, Wu S, Hua C, Navid F, Rodriguez-Galindo C, Rao BN, Hoth KA, Neel MD, Merchant TE, Kun LE, Spunt SL. Preliminary results of a prospective study using limited margin radiotherapy in pediatric and young adult patients with high grade nonrhabdomyosarcoma soft-tissue sarcoma. Int J Radiat Oncol Biol Phys 76(3):874-8, 2010.
Krasin MJ, Hoth KA, Hua C, Gray JM, Wu S, Xiong X. Incidence and correlates of radiation dermatitis in children and adolescents receiving radiation therapy for the treatment of paediatric sarcomas. Clin Oncol 21(10):781-5, 2009.
Hua C, Bass JK, Khan R, Kun LE, Merchant TE. Hearing loss after radiotherapy for pediatric brain tumors: effect of cochlear dose. Int J Radiat Oncol Biol Phys 72(3):892-9, 2008.
Merchant TE, Hua C, Shukla HI, Ying X, Nil S, Elfie U. Proton vs. photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function. Pediatr Blood & Cancer 51(1):110-7, 2008.
Hua C, Gray JM, Merchant TE, Kun LE, Krasin MJ. Treatment planning and delivery of external beam radiotherapy for pediatric sarcoma: the St. Jude Children’s Research Hospital experience. Int J Radiat Oncol Biol Phys 70(5):1598-606, 2008.
Hua C, Sheila HI, Merchant TE, Krasin MJ. Estimating difference in volumetric flat bone growth in pediatric patients by radiation treatment method. Int J Radiat Oncol Biol Phys 67(2):552-8, 2007.
Lovelock M, Hua C, Wang P, Hunt M, Fournier-Bides N, Yenice K, Toner S, Lutz W, Amoles H, Bilks M, Funks Z, Yamada Y. Accurate setup of para spinal patients using a noninvasive patient immobilization cradle and portal imaging. Med Phys 32(8):2606-14, 2005.
Hua C, Chang J, Yenice K, Chan M, Amols H. A practical approach to prevent gantry-couch collision for linac-based radiosurgery. Med Phys 31(7):2128-34, 2004.
Hua C, Lovelock M, Mageras GS, Katz MS, Mechalakos J, Lief EP, Hollister T, Lutz WR, Zelefsky MJ, Ling CC. Development of a semi-automatic alignment tool for accelerated localization of the prostate.Int J Radiat Oncol Biol Phys 55(3):811-24, 2003.
Yenice K, Lovelock M, Lutz W, Fournier-Bidoz N, Hua C, Yamada J, Bilsky M, Hunt M, Amols H. CT-image guided intensity modulated therapy of paraspinal tumors. Int J Radiat Oncol Biol Phys 55(3):583-93, 2003.
Last update: March 2018