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Matthew J. Krasin, MD
Matthew J. Krasin, MD

Matthew J. Krasin, MD

Member, St. Jude Faculty



BS – Texas A&M University (1991)
MD – University of Texas, Galveston (1995)

Honors & Awards

  • 2012 Outstanding Physician, St. Jude Children’s Research Hospital

Research Interests

I serve as a Full Faculty Member in the Department of Radiation Oncology at St. Jude Children’s Research Hospital. My clinical and academic activities are focused on pediatric solid tumors and Hodgkin lymphoma, their radiation late effects, and how modalities like proton beam radiation may mitigate these effects. Therapy specific accomplishments include completion of sequential investigator initiated trials for pediatric rhabdomyosarcoma, implementation and study of conformal type treatment guidelines (including proton beam) for Hodgkin lymphoma and most recently developing an investigator initiated trial for Wilms’ tumor incorporating conformal targeting guidelines and proton beam radiation.  My research focus includes improving the radiation target definitions for solid tumors and Hodgkin lymphoma while maintaining local disease control, as well as defining the relationships between radiation dose, volume treated and late side effects.


  • Rhabdomyosarcoma (RMS)
  • Soft-tissue Sarcoma (STS)
  • Ewing Sarcoma (ES)
  • Hodgkin Lymphoma

Special Interests

  • Sarcomas
  • Proton beam
  • Side effects of radiation
  • Brachytherapy for pediatric tumors

Selected Publications

Ates O, Pirlepesov F, Uh J, Hua CH, Merchant TE, Boria A, Davidoff AM, Graetz DE, Krasin MJ. Evaluating the impact of bowel gas variations for Wilms' tumor in pediatric proton therapy. Cancers (Basel) Feb 2;16(3):642, 2024.

Gutkin PM, Skinner L, Jiang A, Donaldson SS, Loo BW Jr, Oh J, Wang YP, von Eyben R, Snyder J, Bredfeldt JS, Breneman JC, Constine LS, Faught AM, Haas-Kogan D, Holmes JA, Krasin M, Larkin C, Marcus KJ, Maxim PG, McClelland S 3rd, Murphy B, Palmer JD, Perkins SM, Shen CJ, Terezakis S, Bush K, Hiniker SM. Feasibility of the audio-visual assisted therapeutic ambience in radiotherapy (AVATAR) system for anesthesia avoidance in pediatric patients: A multicenter trial. Int J Radiat Oncol Biol Phys Sept 9;117(1):96-104, 2023.

Ates O, Uh J, Pirlepesov F, Hua CH, Merchant TE, Krasin MJ. Monitoring of interfractional proton range verification and dosimetric impact based on daily CBCT for pediatric patients with pelvic tumors. Cancers (Basel) Aug 22;15(17):4200, 2023.

Metzger ML, Link MP, Billett AL, Flerlage J, Lucas JT Jr, Mandrell BN, Ehrhardt MJ, Bhakta N, Yock TI, Friedmann AM, de Alarcon P, Luna-Fineman S, Larsen E, Kaste SC, Shulkin B, Lu Z, Li C, Hiniker SM, Donaldson SS, Hudson MM, Krasin MJ. Excellent Outcome for Pediatric Patients With High-Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation. J Clin Oncol Jul 10;39(20):2276-2283, 2021. doi: 10.1200/JCO.20.03286. Epub 2021 Apr 7. PMID: 33826362; PMCID: PMC8260923

Tinkle CL, Singh C, Lloyd S, Guo Y, Li Y, Pappo AS, DuBois SG, Lucas JT Jr, Haas-Kogan DA, Terezakis SA, Braunstein SE, Krasin MJ. Stereotactic Body Radiation Therapy for Metastatic and Recurrent Solid Tumors in Children and Young Adults. Int J Radiat Oncol Biol Phys Apr 1;109(5):1396-1405, 2021. doi: 10.1016/j.ijrobp.2020.11.054. Epub 2020 Nov 28. PMID: 33259934; PMCID: PMC7965242

Ates O, Hua CH, Zhao L, Shapira N, Yagil Y, Merchant TE, Krasin M. Feasibility of using post-contrast dual-energy CT for pediatric radiation treatment planning and dose calculation. Br J Radiol Feb 1;94(1118):20200170, 2021. doi: 10.1259/bjr.20200170. Epub 2020 Nov 19. PMID: 33201728; PMCID: PMC7934321

Sapkota Y, Wilson CL, Zaidi AK, Moon W, Fon Tacer K, Lu L, Liu Q, Baedke J, Dhaduk R, Wang Z, Chemaitilly W, Krasin MJ, Berry FB, Zhang J, Hudson MM, Robison LL, Green DM, Yasui Y. A Novel Locus Predicts Spermatogenic Recovery among Childhood Cancer Survivors Exposed to Alkylating Agents. Cancer Res Sep 1;80(17):3755-3764, 2020. doi: 10.1158/0008-5472.CAN-20-0093. Epub 2020 Jun 17. PMID: 32554749; PMCID: PMC7731186

Tinkle CL, Pappo A, Wu J, Mao S, Hua CH, Shulkin BL, McCarville MB, Kaste SC, Davidoff AM, Bahrami A, Green DM, Ness KK, Merchant TE, Spunt SL, Krasin MJ. Efficacy and Safety of Limited-Margin Conformal Radiation Therapy for Pediatric Rhabdomyosarcoma: Long-Term Results of a Phase 2 Study. Int J Radiat Oncol Biol Phys May 1;107(1):172-180, 2020. doi: 10.1016/j.ijrobp.2020.01.011. Epub 2020 Jan 25. PMID: 31987969; PMCID: PMC7668436

Indelicato DJ, Rotondo RL, Krasin MJ, Mailhot Vega RB, Uezono H, Bradfield S, Agarwal V, Morris CG, Bradley JA. Outcomes Following Proton Therapy for Group III Pelvic Rhabdomyosarcoma. Int J Radiat Oncol Biol Phys Apr 1;106(5):968-976, 2020. doi: 10.1016/j.ijrobp.2019.12.036. Epub 2020 Jan 25. PMID: 31987977

Rodriguez-Galindo C, Krailo MD, Krasin MJ, Huang L, McCarville MB, Hicks J, Pashankar F, Pappo AS. Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children's Oncology Group ARAR0331 Study. J Clin Oncol Dec 10;37(35):3369-3376, 2019. doi: 10.1200/JCO.19.01276. Epub 2019 Sep 25. Erratum in: J Clin Oncol. 2021 May 10;39(14):1602. PMID: 31553639; PMCID: PMC6920031

Tinkle CL, Lu J, Han Y, Li Y, McCarville BM, Neel MD, Bishop MW, Krasin MJ. Curative-intent radiotherapy for pediatric osteosarcoma: The St. Jude experience. Pediatr Blood Cancer Aug;66(8):e27763, 2019. doi: 10.1002/pbc.27763. Epub 2019 Apr 22. PMID: 31012273; PMCID: PMC6588458

Tinkle CL, Williams NL, Wu H, Wu J, Kaste SC, Shulkin BL, Talleur AC, Flerlage JE, Hudson MM, Metzger ML, Krasin MJ. Treatment patterns and disease outcomes for pediatric patients with refractory or recurrent Hodgkin lymphoma treated with curative-intent salvage radiotherapy. Radiother Oncol May;134:89-95, 2019. doi: 10.1016/j.radonc.2019.01.026. Epub 2019 Feb 5. PMID: 31005229; PMCID: PMC6478442

Green DM, Wang M, Krasin MJ, Srivastava D, Relling MV, Howell CR, Ness KK, Kaste SC, Greene W, Jay DW, Fernandez-Pineda I, Pui CH, Jeha S, Bishop MW, Furman WL, Robison LL, Hudson MM. Serum Alanine Aminotransferase Elevations in Survivors of Childhood Cancer: A Report From the St. Jude Lifetime Cohort Study. Hepatology Jan;69(1):94-106, 2019. doi: 10.1002/hep.30176. Epub 2018 Dec 25. PMID: 30016547; PMCID: PMC6324960

Tinkle CL, Fernandez-Pineda I, Sykes A, Lu Z, Hua CH, Neel MD, Bahrami A, Shulkin BL, Kaste SC, Pappo A, Spunt SL, Krasin MJ. Nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) in pediatric and young adult patients: Results from a prospective study using limited-margin radiotherapy. Cancer Nov 15;123(22):4419-4429, 2017. doi: 10.1002/cncr.30793. Epub 2017 Jul 31. PMID: 28759114; PMCID: PMC5673566

Last update: April 2024