MD, PhD – Jefferson Medical College, Philadelphia, Pennsylvania
Post-doctoral Fellowship – Translational and Functional Genomics Branch, NHGRI/NIH, Bethesda, Maryland
Residency (Clinical Pathology) – Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Fellowship (Hematopathology) – Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Honors & Awards
- 2012 American Society of Hematology Junior Faculty Scholar Award
- 2006 Burroughs Wellcome Fund Career Award in the Biomedical Sciences
- 2006 American Society of Hematology Fellow Scholar Award
- 2001 American Society of Bone and Mineral Research Young Investigator Award
- 2000 Outstanding research presentation award, NHGRI annual retreat
- 2000 Damon Runyon Cancer Research Foundation Fellowship Award
- 1999 National Science Foundation Fellowship Award
- 1996 William Potter Wear Research Prize, Jefferson Medical College
- 1991 Gibbon’s Scholar Fellowship, Jefferson Medical College
- 1991 Foederor Scholarship Award, Jefferson Medical College
My research is motivated by a desire to develop novel insights into the pathogenesis of hematopoietic disorders, including myelodysplastic syndromes and acute leukemias, to guide the development of improved diagnostic tools and therapies. In particular, I would like to understand the molecular mechanisms involved in mitochondrial clearance and determine whether perturbations of this pathway can contribute to hematopoietic malignancies.
Joo JH, Wang B, Frankel E, Ge L, Xu L, Iyengar R, Li-Harms X, Wright C, Shaw TI, Lindsten T, Green DR, Peng J, Hendershot LM, Kilic F, Sze JY, Audhya A, Kundu M. The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis. Mol Cell 62: 491-506, 2016. *Highlighted in Zhao YG and Zhang H. The Incredible ULKs: Autophagy and Beyond. Molecular Cell 63: 475-476, 2016.
Joshi A, Iyengar R, Joo JH, Li-Harms XJ, Wright C, Marino R, Winborn BJ, Phillips A, Temirov J, Sciarretta S, Kriwacki R, Peng J, Shelat A, Kundu M. Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1. Cell Death Differ 23:216-230, 2016.
Lim J, Lachenmayer L, Wu S, Liu W, Kundu M, Wang R, Komatsu M, Oh YJ, Zhao Y, Yue Z. Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates PLoS Genet 11:e1004987, 2015.
Li-Harms X, Milasta S, Lynch J, Wright C,Joshi A, Iyengar R, Neale G, Wang X, Wang Y-D, Prolla TA, Thompson JE, Opferman JT, Green DR, Schuetz J, Kundu M. Mito-protective autophagy is suppressed in erythroid cells of mtDNA mutator mice. Blood 125:162-74, 2015.
Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol 14:480-488, 2013.
Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP, Winborn BJ, Moore J, Lee JY, Yao TP, Pallanck L, Kundu M, Taylor JP. VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations. Neuron 78:65-80, 2013.
Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, Steeves MA, Yang CY, Prater SM, Kim DH, Thompson CB, Youle RJ, Ney PA, Cleveland JL, Kundu M. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13 -mediated mitophagy. Molecular Cell 43: 572-585, 2011.
Löffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, Campbell DG, Wesselborg S, Alessi DR, Stork B. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy 7: 696-706, 2011.
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13:132-141, 2011.
Egan DF, Shackelford DB, Mihaylova MM, Gelino SR, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy. Science 331:456-61, 2011
Chen ML, Logan TD, Hochberg ML, Shelat SG, Yu X, Wilding GE, Tan W, Kujoth GC, Prolla TA, Selak MA, Kundu M, Carroll M, Thompson JE. Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction. Blood 114:4045-53, 2009.
Zhang J, Randall MS, Loyd MR, Dorsey FC, Kundu M, Cleveland JL, Ney PA. Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood 114:157-64, 2009.
Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery. Mol Biol Cell 20:1992-2003, 2009.
Kundu M, Lindsten T, Yang C-Y, Wu J, Zhao F, Zhang J, Selak MA, Ney PA, Thompson CB. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 112:1493-502, 2008.
Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, Kundu M, Opferman JT, Cleveland JL, Miller JL, and Ney PA. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 104:19500-5, 2007.
Last update: July 2016