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Wojciech Rosikiewicz, PhD

Wojciech Rosikiewicz, PhD

  • Bioinformatics Research Scientist, Epigenetics

Education

PhD, Biological Sciences - Institute of Anthropology, Department of Integrative Genomics, Adam Mickiewicz University, Poznan, Poland
MS
, Biotechnology - Adam Mickiewicz University, Poznan, Poland
BS
, Biology - Adam Mickiewicz University, Poznan, Poland

About

Dr. Wojciech Rosikiewicz is a computational scientist experienced in studying the pathology of various blood cancers, especially Diffused Large B-cell Lymphoma. He applied known and also developed novel bioinformatics approaches to analyze and integrate genomics and epigenomics data, mostly taking advantage of Python programming language and machine learning. He has experience on various next generation sequencing data types, such as histone modifications (ChIP-Seq), DNA methylation and hydroxymethylation (RRBS, WGBS, oxBS, ACE-Seq, hMeDIP-Seq), chromatin 3D structure (HiC), Oxford Nanopore sequencing data and transcriptomic data (RNA-Seq, expression microarrays, TSS-Seq). He also learned HTML, PHP and MySQL that allow him to develop the following on-line databases, providing researchers access to his work:

Research Interests

  • The pathology of various blood cancers
  • Regulation of gene expression
  • Epigenetics

Selected Publications

Rosikiewicz W, et al. TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis. Science Advances. 2020 Jun 17, doi: 10.1126/sciadv.aay5872

Ashoor H, Chen X, Rosikiewicz W, Wang J, Cheng A, Wang P, Ruan Y, Li S. Graph embedding and unsupervised learning predict genomic sub-compartments from HiC chromatin interaction data. Nat Commun. 2020 Mar 3;11(1):1173. doi: 10.1038/s41467-020-14974-x.

Taghbalout, A., Du, M., Jillette, N., Rosikiewicz W., Rath, A., Heinen, C. D., … Cheng, A. W. (2019). Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways. Nat Commun. 10, 1–12. https://doi.org/10.1038/s41467-019-12339-7.

Dominguez PM*, Ghamlouch H*, Rosikiewicz W*, et al. TET2 deficiency causes germinal center hyperplasia, impairs plasma cell differentiation and promotes B-cell lymphomagenesis, Cancer Discovery. 2018 Oct 1, 

Rosikiewicz W, Suzuki Y, Makalowska I., OverGeneDB: a database of 5’ end protein coding overlapping genes in human and mouse genomes, Nucleic Acids Research, 2018 Jan 4;46(D1):D186-D193.

Rosikiewicz W, Kabza M, Kubiak MR, Kosinski J, Makalowska I., RetogeneDB – a database of animal and plant retrocopies, Database (Oxford), 14 June 2017

Rosikiewicz W, Makalowska I, Biological Functions of Natural Antisense Transcripts, Acta Biochimica Polonica, 2016;63(4):665-673. Epub 2016 Oct 21

Full List of Publications

Last update: June 2020