Frontiers in Innate Immunity and Cell Death

Please join us in person at “Frontiers in Innate Immunity and Cell Death”, the 3rd annual Symposium hosted by the Center of Excellence for Innate Immunity and Inflammation (CoE-III) at St. Jude Children’s Research Hospital in Memphis, TN, on Tuesday, November 4, 2025.  

The innate immune system plays a critical role in infectious, inflammatory, and autoimmune diseases and cancers. Despite this importance, our understanding of how the innate immune system recognizes and responds to diverse pathogens or danger signals to drive host defense, clear cancerous cells, regulate cell death pathways, control cytokine production, and engage the adaptive immune response remains limited. Furthermore, inborn errors in innate immune genes and aberrant innate immune signaling are key drivers of disease, but the underlying molecular mechanisms are incompletely understood, limiting our ability to therapeutically target these processes.

The 2025 Symposium will bring together an outstanding, international group of leading experts to share recent discoveries in innate immunity and cell death, featuring topics on the basic biology of innate immunity, interactions with adaptive immunity, the molecular diversity of immune mechanisms, immuno-oncology, neuroimmunology, the pathophysiology of inflammation, therapeutic applications, and more. 

The CoE-III Symposium will be held in-person at St. Jude. While the previous CoE-III Symposia have been exclusive to the St. Jude research community, this year, we are excited to offer opportunities for external registrants to join us. We look forward to welcoming the innate immunity research community for robust discussions and interactions to support  basic and translational research and advance cures.