Young-Goo Han, PhD
Young-Goo Han, PhD

Young-Goo Han, PhD

Assistant Member, St. Jude Faculty

Departments

Divisions

Education

BS – Seoul National University, Korea
MS – Seoul National University, Korea
PhD – State University of New York, Stony Brook

Research Interests

  • Function of primary cilia in brain development
  • Function of primary cilia in tumorigenesis
  • Molecular mechanism of ciliary function in signaling pathways

Selected Publications

Campos Y, Qiu X, Gomero E, Wakefield R, Horner L, Brutkowski W, Han YG, Solecki D, Frase S, Bongiovanni A, d'Azzo A. Alix-mediated assembly of the actomyosin-tight junction polarity complex preserves epithelial polarity and epithelial barrier. Nat Commun 7:11876, 2016. 

Wang L, Hou S, Han YG. Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex. Nat Neurosci 19(7):888-96, 2016.

Vo BT, Wolf E, Kawauchi D, Gebhardt A, Rehg JE, Finkelstein D, Walz S, Murphy BL, Youn YH, Han YG, Eilers M, Roussel MF. The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity. Cancer Cell 29(1):5-16, 2016.

Tong CK, Han YG, Shah JK, Obernier K, Guinto CD, Alvarez-Buylla A. Primary cilia are required in a unique subpopulation of neural progenitors. Proc Natl Acad Sci U S A 111(34):12438-43, 2014.

Marada S, Stewart DP, Bodeen WJ, Han YG, Ogden SK. The unfolded protein response selectively targets active smoothened mutants. Mol Cell Biol 33(12):2375-2387, 2013.

Hou S, Han YG. Primary cilia and brain cancer. In Cilia and Nervous System Development & Function (Caspary T, Tucker KL Eds). Springer 2013 (in press).

Venere M, Han YG, Bell R, Song JS, Alvarez-Buylla A, Blelloch R. Sox1 marks an activated neural stem/progenitor cell in the hippocampus. Development Nov;139(21):3938-49, 2012.

Mirzadeh Z, Han YG, Garcia-Verdugo JM, Alvarez-Buylla A. Epithelial Organization of Adult Neurogenic Germinal Niche. In Neurogenesis in the Adult Brain 1 (Seki T, Swamoto K, Parent JM, Alvarez-Buylla A Eds). Springer 287-317, 2011.

Han YG, Alvarez-Buylla A. Primary Cilia as Switches in Brain Development and Cancer. In Two Faces of Evil: Cancer and Neurodegeneration (T Curran, Y Christen Eds). Springer 73-82, 2011.

Guirao B, Meunier A, Mortaud S, Aguilar A, Corsi JM, Strehl L, Hirota Y, Desoeuvre A, Boutin C, Han YG, Mirzadeh Z, Cremer H, Montcouquiol M, Sawamoto K, Spassky N. Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia. Nat Cell Biol Apr;12(4):341-50, 2010.

Han YG, Alvarez-Buylla A. Role of Primary Cilia in Brain Development and Cancer. Curr Opin Neurobiol Feb;20(1):58-67, 2010.

Mirzadeh Z, Han YG, Soriano-Navarro M, García-Verdugo JM, Alvarez-Buylla A. Cilia regulate planar cell polarity of ependymal cells. J Neurosci Feb 17;30(7):2600-10. 2010.

Han YG, Kim HJ, DlugoszAA, EllisonDW, Gilbertson RJ, and Alvarez-BuyllaA. Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med Sep;15(9):1062-5, 2009.

Schüller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, Huillard E, Sun T, Ligon AH, Qian Y, Ma Q, Alvarez-Buylla A, McMahon AP, Rowitch DH, Ligon KL. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma. Cancer Cell Aug 12;14(2):123-134, 2008.

Spassky N*, Han YG*, Aguilar A, Strehl L, Besse L, Laclef C, Ros MR, Garcia-Verdugo JM, Alvarez-Buylla A. Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool. Dev Biol May 1;317(1):246-59, 2008. *Equal contribution

Han YG, Spassky N, Romaguera-Ros M, Garcia-Verdugo JM, Aguilar A, Schneider-Maunoury S, Alvarez-Buylla A. Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat Neurosci Mar;11(3):277-84, 2008.

Han YG, Kwok BH, Kernan MJ. Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. Curr Biol Sep 30;13(19):1679-86, 2003.

Chung YD, Zhu J, Han Y, Kernan MJ. nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures. Neuron Feb;29(2):415-28, 2001.

Han YG, Kang SS, Seong JY, Geum D, Suh YH, Kim K. Negative regulation of gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor gene expression by a gonadotrophin-releasing hormone agonist in the rat hypothalamus. J Neuroendocrinol Mar;11(3):195-201, 1999.

Seong JY, Kang SS, Kam K, Han YG, Kwon HB, Ryu K, Kim K. Differential regulation of gonadotropin-releasing hormone (GnRH) receptor expression in the posterior mediobasal hypothalamus by steroid hormones: implication of GnRH neuronal activity. Brain Res Mol Brain Res Jan;53(1-2):226-35, 1998.

Last update: July 2016