Mark E. Hatley, MD, PhD
Mark E. Hatley, MD, PhD

Mark E. Hatley, MD, PhD

Assistant Member, St. Jude Faculty




BS – University of Central Oklahoma, Edmond, Oklahoma
MD, PhD – University of Texas Southwestern Medical Center at Dallas, Medical Scientist Training Program, Dallas, Texas

Research Interests

  • Cellular and molecular origins of embryonal rhabdomyosarcoma
  • MicroRNAs in pediatric sarcomas
  • Mouse models of pediatric sarcomas
  • Development of novel therapies for pediatric sarcomas

Selected Publications

Hatley ME, Tang W, Garcia MR, Finkelstein D, Millay DP, Liu N, Graff J, Galindo RL, Olson EN. A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell 16:536-46, 2012. PMCID: PMC3479681

Hatley ME, Patrick DM, Garcia MR, Ricardson JA, Bassel-Duby R, van Rooij, Olson EN. Modulation of K-ras-dependent lung tumorigenesis by microRNA-21. Cancer Cell 18:282-93, 2010. PMCID: PMC2971666.

Hatley ME, Lockless SW, Gibson SK, Gilman AG, Ranganathan R. Allosteric determinants of guanine nucleotide binding proteins. Proceedings of the National Academy of Science 100:14445-50, 2003.

Hatley ME, Gilman AG, Sunahara RK. Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases. Methods in Enzymology 345:127-40, 2002.

Hatley ME, Benton BK, Xu J, Manfredi JP, Gilman AG, Sunahara RK. Isolation and characterization of constitutively active mutants of mammalian adenylyl cyclase. Journal Biological Chemistry 275(49):38626-32, 2000.

O’Hair RAJ, Freitas MA, Schmidt JAR, Hatley ME, Williams TD. Gas-phase methylation fo 2-hydroxypyridine/2-pyridone system by the dimethylchloronium ion. European Mass Spectrometry 1:457-463,1995.

Last update: February 2013