Mark E. Hatley, MD, PhD
Mark E. Hatley, MD, PhD

Mark E. Hatley, MD, PhD

Assistant Member, St. Jude Faculty




BS – University of Central Oklahoma, Edmond, Oklahoma
MD, PhD – University of Texas Southwestern Medical Center at Dallas, Medical Scientist Training Program, Dallas, Texas

Research Interests

  • Cellular and molecular origins of embryonal rhabdomyosarcoma
  • MicroRNAs in pediatric sarcomas
  • Mouse models of pediatric sarcomas
  • Development of novel therapies for pediatric sarcomas

Selected Publications

Hanna JA, Garcia MR, Go JC, Finkelstein D, Kodali K, Pagala V, Wang X, Peng J, Hatley ME. PAX7 is a required target for microRNA-206 induced differentiation of fusion-negative rhabdomyosarcoma. Cell Death and Disease 7:e2256, 2016.

Kashi VP, Hatley ME,* Galindo RL.* Probing for a deeper understanding of rhabdomyosarcoma: insights from complementary model systems. Nature Reviews Cancer 15:426-439, 2015. *co-corresponding authors. PMCID: PMC4599785

White K, Dempsie Y, Caruso P, Wallace E, McDonald R, Stevens H, Hatley ME, van Rooij E, Morrell N, MacLean M, Baker A. Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension 64:185-94, 2014. 

Chen X, Stewart E, Shelat AA, Qu C, Bahrami A, Hatley M, Wu G, Bradley C, McEvoy J, Pappo A, Spunt S, Valentine MB, Valentine V, Krafcik F, Lang WH, Wierdl M, Tsurkan L, Tolleman V, Federico SM, Morton C, Lu C, Ding L, Easton J, Rusch M, Nagahawatte P, Wang J, Parker M, Wei L, Hedlund E, Finkelstein D, Edmonson M, Shurtleff S, Boggs K, Mulder H, Yergeau D, Skapek S, Hawkins DS, Ramirez N, Potter PM, Sandoval JA, Davidoff AM, Mardis ER, Wilson RK, Zhang J, Downing JR, Dyer MA. Targeting oxidative stress in embryonal rhabdomyosarcoma. Cancer Cell  24:710-724, 2013.  PMCID: PMC3904731.

Hatley ME, Tang W, Garcia MR, Finkelstein D, Millay DP, Liu N, Graff J, Galindo RL, Olson EN. A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell 16:536-46, 2012. PMCID: PMC3479681

Hatley ME, Patrick DM, Garcia MR, Ricardson JA, Bassel-Duby R, van Rooij, Olson EN. Modulation of K-ras-dependent lung tumorigenesis by microRNA-21. Cancer Cell 18:282-93, 2010. PMCID: PMC2971666.

Hatley ME, Lockless SW, Gibson SK, Gilman AG, Ranganathan R. Allosteric determinants of guanine nucleotide binding proteins. Proceedings of the National Academy of Science 100:14445-50, 2003.

Hatley ME, Gilman AG, Sunahara RK. Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases. Methods in Enzymology 345:127-40, 2002.

Hatley ME, Benton BK, Xu J, Manfredi JP, Gilman AG, Sunahara RK. Isolation and characterization of constitutively active mutants of mammalian adenylyl cyclase. Journal Biological Chemistry 275(49):38626-32, 2000.

Last update: June 2016