The Division of Molecular Oncology investigates the molecular and cellular determinants that lead to tumor formation and that dictate cellular responses to cytotoxic stresses. Emphasis is placed on translating information gained on the latter topic to the development of novel therapeutic approaches to cancer.
The Division of Molecular Oncology is a laboratory-based research group within the Department of Oncology. Basic science investigations focus on the molecular differences between normal cells and tumor cells and on the molecular mechanisms that determine cellular responses to DNA damage and other cytotoxic stresses. Current areas of interest include investigations of oncogenes and tumor suppressor genes in tumor development, such as telomerase, the retinoblastoma gene and protein, the p53 gene and protein, the ATM and ATR genes and proteins, and the Brca1 protein. There is also a particular focus on the molecular controls of cellular responses to ionizing irradiation, which has implications for both tumor formation and tumor responses to chemotherapy and radiation therapy. Identification of the steps involved in signaling pathways initiated by radiation and other cytotoxic stresses also provide new potential targets for the design of novel drugs that can be used to enhance the sensitivity of tumor cells to radiation or chemotherapy.
Division of Molecular Oncology
MS 354, Room D5048
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-1049
Fax: (901) 595-0817
Preferred contact method: email
Cellular and genetic origins of childhood cancers
Molecular pathology of infantile leukemia and megakaryoblastic leukemia
Cellular and molecular origins of rhabdomyosarcoma
SWI/SNF (BAF) chromatin remodeling/tumor suppressor